Srivastava, Prabhakar L. ORCID: https://orcid.org/0000-0002-8219-6419, Johns, Sam T., Voice, Angus, Morley, Katharine, Escorcia, Andrés M., Miller, David J., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and van der Kamp, Marc W. 2024. Simulation-guided engineering enables a functional switch in selinadiene synthase toward hydroxylation. ACS Catalysis 14 (14) , 11034–11043. 10.1021/acscatal.4c02032 |
González Requena, Víctor, Srivastava, Prabhakar L. ORCID: https://orcid.org/0000-0002-8219-6419, Miller, David J. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2024. Single point mutation abolishes water capture in germacradien‐4‐ol synthase. ChemBioChem , e202400290. 10.1002/cbic.202400290 |
Johnson, Luke A. ORCID: https://orcid.org/0000-0002-6697-6589, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2024. A photoresponsive homing endonuclease for programmed DNA cleavage. ACS Synthetic Biology 13 (1) , pp. 195-205. 10.1021/acssynbio.3c00425 |
Srivastava, PrabhakarL. ORCID: https://orcid.org/0000-0002-8219-6419, Johns, Sam T., Walters, Rebecca, Miller, David J., Van der Kamp, Marc W. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2023. Active site loop engineering abolishes water capture in hydroxylating sesquiterpene synthases. ACS Catalysis 13 (21) , pp. 14199-14204. 10.1021/acscatal.3c03920 |
Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Samperio, Raquel, Mart, Robert ORCID: https://orcid.org/0000-0003-2196-5840, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088, Jones, Arwyn ORCID: https://orcid.org/0000-0003-2781-8905 and Cruz Samperio, Raquel 2022. Spatio-temporal control of cell death by selective delivery of photo-activatable proteins. ChemBioChem 23 (12) , e202200115. 10.1002/cbic.202200115 |
Adesina, Aduragbemi S., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2021. Cryo‐kinetics reveal dynamic effects on the chemistry of human dihydrofolate reductase. ChemBioChem 22 (14) , pp. 2410-2414. 10.1002/cbic.202100017 |
Pospiech, Mateusz, Owens, Siân E., Miller, David J., Austin-Muttitt, Karl, Mullins, Jonathan G. L., Cronin, James G., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and Sheldon, I. Martin 2021. Bisphosphonate inhibitors of squalene synthase protect cells against cholesterol-dependent cytolysins. FASEB Journal 35 (6) , e21640. 10.1096/fj.202100164R |
Srivastava, Prabhakar L. ORCID: https://orcid.org/0000-0002-8219-6419, Escorcia, Andrés M., Huynh, Florence, Miller, David J., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and van der Kamp, Marc W. 2021. Redesigning the molecular choreography to prevent hydroxylation in Germacradien-11-ol synthase catalysis. ACS Catalysis 11 (3) , 1033–1041. 10.1021/acscatal.0c04647 |
Huynh, Florence, Tailby, Matthew, Finniear, Aled, Stephens, Kevin, Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2020. Accelerating biphasic biocatalysis through new process windows. Angewandte Chemie International Edition 59 (38) , pp. 16490-16495. 10.1002/anie.202005183 |
Elsherbini, Mohamed, Huynh, Florence, Dunbabin, Alice, Allemann, Rudolf ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2020. Selective hydroboration - oxidation of terminal alkenes under flow conditions. Chemistry - A European Journal 26 (50) , pp. 11423-11425. 10.1002/chem.202001650 |
Adesina, Aduragbemi S., Swiderek, Katarzyna, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2020. Electric field measurements reveal the pivotal role of Cofactor-Substrate interaction in dihydrofolate reductase catalysis. ACS Catalysis 10 (14) , pp. 7907-7914. 10.1021/acscatal.0c01856 |
Johnson, Luke A. ORCID: https://orcid.org/0000-0002-6697-6589, Dunbabin, Alice, Benton, Jennifer C. R., Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2020. Modular chemoenzymatic synthesis of terpenes and their analogues. Angewandte Chemie International Edition 59 (22) , pp. 8486-8490. 10.1002/anie.202001744 |
Valikhani, Donya, Srivastava, Prabhakar L. ORCID: https://orcid.org/0000-0002-8219-6419, Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2020. Immobilised enzymes for sesquiterpene synthesis in batch and flow systems. ChemCatChem 12 (8) , pp. 2194-22197. 10.1002/cctc.201902135 |
Day, Adam H., Ubler, Martin H., Best, Hannah L., Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182, Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Al-Wattar, Eman A. H., Keymer, Nathaniel I., Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057 and Pope, Simon J. A. ORCID: https://orcid.org/0000-0001-9110-9711 2020. Targeted cell imaging properties of a deep red luminescent iridium(III) complex conjugated with a c-Myc signal peptide. Chemical Science 11 (6) , pp. 1599-1606. 10.1039/C9SC05568A |
Cresser-Brown, Joel, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Roth, Christian, Miller, David J. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2020. An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq. Acta Crystallographica Section F: Structural Biology Communications 76 (2) , pp. 81-85. 10.1107/S2053230X20001181 |
Allemann, Rudolf K ORCID: https://orcid.org/0000-0002-1323-8830, Scott, Alan F., Luk, Louis Y.-P. ORCID: https://orcid.org/0000-0002-7864-6261, Tuñón, Iñaki and Moliner, Vicent 2019. Heavy enzymes and the rational redesign of protein catalysts. ChemBioChem 20 (22) , pp. 2807-2812. 10.1002/cbic.201900134 |
Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Loss of hyperconjugative effects drives hydride transfer during dihydrofolate reductase catalysis. ACS Catalysis 9 (11) , pp. 10343-10349. 10.1021/acscatal.9b02839 |
Elsherbini, Mohamed, Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2019. 'Dark' singlet oxygen made easy. Chemistry - A European Journal 25 (54) , pp. 12486-12490. 10.1002/chem.201903505 |
Demiray, Melodi, Miller, David J and Allemann, Rudolf K ORCID: https://orcid.org/0000-0002-1323-8830 2019. Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids. Beilstein Journal of Organic Chemistry 15 , pp. 2184-2190. 10.3762/bjoc.15.215 |
Kalvaitis, Mindaugas E., Johnson, Luke A. ORCID: https://orcid.org/0000-0002-6697-6589, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. A noncanonical chromophore reveals structural rearrangements of the light-oxygen-voltage domain upon photoactivation. Biochemistry 58 (22) , pp. 2608-2616. 10.1021/acs.biochem.9b00255 |
Scott, Alan F., Cresser-Brown, Joel, Williams, Thomas L., Rizkallah, Pierre J. ORCID: https://orcid.org/0000-0002-9290-0369, Jin, Yi ORCID: https://orcid.org/0000-0002-6927-4371, Luk, Louis Y.-P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Crystal structure and biophysical analysis of furfural detoxifying aldehyde reductase from clostridium beijerinkii. Applied and Environmental Microbiology 10.1128/AEM.00978-19 |
Ruiz-Pernía, J. Javier, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Why are some enzymes dimers? flexibility and catalysis in Thermotoga maritima dihydrofolate reductase. ACS Catalysis 9 , pp. 5902-5911. 10.1021/acscatal.9b01250 |
Patel, Sanjay G., Sayers, Edward J. ORCID: https://orcid.org/0000-0002-2621-1119, He, Lin, Narayan, Rohan, Williams, Thomas L., Mills, Emily M., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Jones, Arwyn T. ORCID: https://orcid.org/0000-0003-2781-8905 and Tsai, Yu-Hsuan ORCID: https://orcid.org/0000-0003-0589-5088 2019. Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Scientific Reports 9 (1) , -. 10.1038/s41598-019-42456-8 |
Loizzi, Marianna, Miller, David J. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2019. Silent catalytic promiscuity in the high-fidelity terpene cyclase δ-cadinene synthase. Organic & Biomolecular Chemistry 17 (5) , pp. 1206-1214. 10.1039/C8OB02821D |
Kalash, Leen, Cresser-Brown, Joel, Habchi, Johnny, Morgan, Connor, Miller, David J., Glen, Robert C., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 and Bender, Andreas 2018. Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space. European Journal of Medicinal Chemistry 157 , pp. 1264-1275. 10.1016/j.ejmech.2018.08.049 |
Huynh, Florence, Grundy, Daniel J., Jenkins, Robert L., Miller, David J. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2018. Sesquiterpene synthase-catalysed formation of a new medium-sized cyclic terpenoid ether from farnesyl diphosphate analogues. Chembiochem 19 (17) , pp. 1834-1838. 10.1002/cbic.201800218 |
Hallett, Andrew J., Placet, Emeline, Prieux, Roxane, McCafferty, Danielle, Platts, James A. ORCID: https://orcid.org/0000-0002-1008-6595, Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571, Isaacs, Marc, Hayes, Anthony J., Coles, Simon J., Pitak, Mateusz B., Marchant, Sarah, Marriott, Stephen N., Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830, Dervisi, Athanasia ORCID: https://orcid.org/0000-0002-0590-5496 and Fallis, Ian A. ORCID: https://orcid.org/0000-0001-7361-0182 2018. Exploring the cellular uptake and localisation of phosphorescent rhenium fac-tricarbonyl metallosurfactants as a function of lipophilicity. Dalton Transactions 47 (40) , pp. 14241-14253. 10.1039/C8DT00669E |
Behiry, Enas M., Ruiz-Pernia, J. Javier, Luk, Louis ORCID: https://orcid.org/0000-0002-7864-6261, Tunon, Inaki, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2018. Isotope substitution of promiscuous alcohol dehydrogenase reveals the origin of substrate preference in the transition state. Angewandte Chemie International Edition 57 (12) , pp. 3128-3131. 10.1002/anie.201712826 |
Loizzi, Marianna, Gonzalez Gonzalez, Veronica, Miller, David J. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2018. Nucleophilic water capture or proton loss: single amino acid switch converts δ-Cadinene synthase into germacradien-4-ol synthase. Chembiochem 19 (1) , pp. 100-105. 10.1002/cbic.201700531 |
Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Dawson, William M., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, E. Joel and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. Chemoenzymatic assembly of isotopically labeled folates. Journal of the American Chemical Society 139 (37) , pp. 13047-13054. 10.1021/jacs.7b06358 |
Scott, Alan F., Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Chemical ligation and isotope labeling to locate dynamic effects. Imperiali, Barbara, ed. Methods in Enzymology, Vol. 596. Elsevier, pp. 23-41. (10.1016/bs.mie.2017.06.040) |
Hughes, Robert L., Johnson, Luke A. ORCID: https://orcid.org/0000-0002-6697-6589, Behiry, Enas M., Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. A rapid analysis of variations in conformational behavior during dihydrofolate reductase catalysis. Biochemistry 56 (15) , pp. 2126-2133. 10.1021/acs.biochem.7b00045 |
Loveridge, Edric Joel, Hroch, Lukas, Hughes, Robert L., Williams, Thomas, Davies, Rhidian L., Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Maglia, Giovanni and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Reduction of folate by dihydrofolate reductase from thermotoga maritima. Biochemistry 56 (13) , pp. 1879-1886. 10.1021/acs.biochem.6b01268 |
Tang, Xiaoping, Demiray, Melodi, Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2017. Concise synthesis of artemisinin from a farnesyl diphosphate analogue. Bioorganic & Medicinal Chemistry 26 (7) , pp. 1314-1319. 10.1016/j.bmc.2017.03.068 |
Demiray, Melodi, Tang, Xiaoping, Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667, Faraldos, Juan A. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. An efficient chemoenzymatic synthesis of dihydroartemisinic aldehyde. Angewandte Chemie International Edition 56 (15) , pp. 4347-4350. 10.1002/anie.201609557 |
Demiray, Melodi, Tang, Xiaoping, Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667, Faraldos, Juan A. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. Effiziente chemoenzymatische Synthese von dhydroartemisinaldehyd. Angewandte Chemie 129 (15) , pp. 4411-4415. 10.1002/ange.201609557 |
Angelastro, Antonio ORCID: https://orcid.org/0000-0002-4023-7411, Dawson, William M., Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2017. A versatile disulfide-driven recycling system for NADP+ with high cofactor turnover number. ACS Catalysis 7 (2) , pp. 1025-1029. 10.1021/acscatal.6b03061 |
Tang, Xiaoping, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2017. Optimising terpene synthesis with flow biocatalysis. European Journal of Organic Chemistry 2017 (2) , pp. 414-418. 10.1002/ejoc.201601388 |
Faraldos, Juan, Grundy, Daniel, Cascon Salgado, Oscar, Leoni, Stefano, van der Kamp, Marc W and Allemann, Rudolf ORCID: https://orcid.org/0000-0002-1323-8830 2016. Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate. Chemical Communications 52 (97) , pp. 14027-14030. 10.1039/C6CC08164A |
Mart, Robert ORCID: https://orcid.org/0000-0003-2196-5840 and Allemann, Rudolf ORCID: https://orcid.org/0000-0002-1323-8830 2016. Azobenzene photocontrol of peptides and proteins. Chemical Communications 52 (83) , pp. 12262-12277. 10.1039/C6CC04004G |
Gonzalez, Veronica, Grundy, Daniel J., Faraldos, Juan A. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2016. The amino-terminal segment in the β-domain of δ-cadinene synthase is essential for catalysis. Organic & Biomolecular Chemistry 14 (31) , pp. 7451-7454. 10.1039/C6OB01398H |
Ruiz-Pernía, J. Javier, Behiry, Enas, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2016. Minimization of dynamic effects in the evolution of dihydrofolate reductase. Chemical Science 7 (5) , pp. 3248-3255. 10.1039/C5SC04209G |
Chen, Mengbin, Chou, Wayne K. W., Al-Lami, Naeemah, Faraldos, Juan, Allemann, Rudolf ORCID: https://orcid.org/0000-0002-1323-8830, Cane, David E. and Christianson, David W. 2016. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry 55 (20) , pp. 2864-2874. 10.1021/acs.biochem.6b00343 |
Mart, Robert ORCID: https://orcid.org/0000-0003-2196-5840, Meah, Dilruba and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2016. Photocontrolled exposure of pro-apoptotic peptide sequences in LOV proteins modulate Bcl-2 family interactions. Chembiochem 17 (8) , pp. 698-701. 10.1002/cbic.201500469 |
Grundy, Daniel J., Chen, Mengbin, Gonzalez, Veronica, Leoni, Stefano ORCID: https://orcid.org/0000-0003-4078-1000, Miller, David James, Christianson, David W. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2016. Mechanism of germacradien-4-ol synthase controlled water capture. Biochemistry 55 (14) , pp. 2112-2121. 10.1021/acs.biochem.6b00115 |
Adams, S.E., Robinson, E.J., Miller, David James, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2015. Conformationally restricted calpain inhibitors. Chemical Science 6 (12) , pp. 6865-6871. 10.1039/c5sc01158b |
Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernía, J. Javier, Adesina, Aduragbemi S., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vincent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2015. Chemical ligation and isotope labeling to locate dynamic effects during catalysis by dihydrofolate reductase. Angewandte Chemie International Edition 54 (31) , pp. 9016-9020. 10.1002/anie.201503968 |
Touchet, Sabrina, Chamberlain, Keith, Woodcock, Christine M., Miller, David J., Birkett, Michael A., Pickett, John A. ORCID: https://orcid.org/0000-0002-1008-6595 and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2015. Novel olfactory ligands via terpene synthases. Chemical Communications 51 (35) , pp. 7550-7553. 10.1039/C5CC01814E |
Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2015. Protein motions and dynamic effects in enzyme catalysis. Physical Chemistry Chemical Physics 17 , pp. 30817-30827. 10.1039/C5CP00794A |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Loveridge, Edric and Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 2015. Protein motions, dynamic effects and thermal stability in dihydrofolate reductase from the hyperthermophile thermotoga maritima. Olivares-Quiroz, Luis, Guzmán-López, Orlando and Jardón-Valadez, Hector Eduardo, eds. Physical Biology of Proteins and Peptides: Theory, Experiment, and Simulation, Springer International Publishing, pp. 99-113. (10.1007/978-3-319-21687-4_6) |
Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernia, J. Javier, Dawson, William M., Loveridge, E. Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2014. Protein isotope effects in dihydrofolate reductase from Geobacillus stearothermophilus show entropic-enthalpic com-pensatory effects on the rate constant. Journal of the American Chemical Society 136 (49) , pp. 17317-17323. 10.1021/ja5102536 |
Gonzalez, Veronica, Touchet, Sabrina, Grundy, Daniel J., Faraldos, Juan A. and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2014. Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-Germacrene A synthase. Journal of the American Chemical Society 136 (41) , pp. 14505-14512. 10.1021/ja5066366 |
Adams, Sarah Elizabeth, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Miller, David James, Robinson, Emma J., Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2014. The structural basis of differential inhibition of human calpain by indole and phenyl α--mercaptoacrylic acids. Journal of Structural Biology 187 (3) , pp. 236-241. 10.1016/j.jsb.2014.07.004 |
Behiry, Enas Mamdouh, Evans, Rhiannon Mari, Guo, Jian Nan, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2014. Loop Interactions during Catalysis by Dihydrofolate Reductase from Moritella profunda. Biochemistry 53 (29) , pp. 4769-4774. 10.1021/bi500508z |
Luk, Louis Y. P. ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, E. Joel and Allemann, Rudolf K. ORCID: https://orcid.org/0000-0002-1323-8830 2014. Different dynamical effects in mesophilic and hyperthermophilic dihydrofolate reductases. Journal of the American Chemical Society 136 (19) , pp. 6862-6865. 10.1021/ja502673h |
Guo, Jian Nan, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2014. Thermal adaptation of dihydrofolate reductase from the moderate thermophile geobacillus stearothermophilus. Biochemistry 53 (17) , pp. 2855-2863. 10.1021/bi500238q |
Ruiz-Pernia, J. Javier, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Garcia-Meseguer, Rafael, Martí, Sergio, Loveridge, Edric Joel, Tuñón, Iñaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Increased dynamic effects in a catalytically compromised variant of Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society 135 (49) , pp. 18689-18696. 10.1021/ja410519h |
Cascón, Oscar, Richter, Gerald, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2013. Efficient terpene synthase catalysis by extraction in flow. ChemPlusChem 78 (11) , pp. 1334-1337. 10.1002/cplu.201300303 |
Miller, David James, Adams, Sarah Elizabeth, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Calpain-1 inhibitors for selective treatment of rheumatoid arthritis: what is the future? Future Medicinal Chemistry 5 (17) , pp. 2057-2074. 10.4155/fmc.13.172 |
Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261, Ruiz-Pernia, J. Javier, Dawson, William Michael, Roca, Maite, Loveridge, Edric Joel, Glowacki, David R., Harvey, Jeremy N., Mulholland, Adrian J., Tunon, Inaki, Moliner, Vicent and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Unraveling the role of protein dynamics in dihydrofolate reductase catalysis. Proceedings of the National Academy of Sciences of the United States of America 110 (41) , pp. 16344-16349. 10.1073/pnas.1312437110 |
Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376, Watkins, Catherine Louise, Chappell, Sally Claire, Wiltshire, Marie, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905, Smith, Paul James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. BH3 helix-derived biophotonic nanoswitches regulate cytochrome c release in permeabilised cells. Molecular BioSystems 9 (11) , pp. 2597-2603. 10.1039/c3mb70246d |
Guo, Jiannan, Loveridge, Edric Joel, Luk, Louis Yu Pan ORCID: https://orcid.org/0000-0002-7864-6261 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Effect of dimerization on dihydrofolate reductase catalysis. Biochemistry 52 (22) , pp. 3881-3887. 10.1021/bi4005073 |
Loveridge, Edric Joel, Matthews, Stella M., Williams, Christopher, Whittaker, Sara B.-M., Günther, Ulrich L., Evans, Rhiannon M., Dawson, William Michael, Crump, Matthew P. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. Aliphatic 1H, 13C and 15N chemical shift assignments of dihydrofolate reductase from the psychropiezophile Moritella profunda in complex with NADP+ and folate. Biomolecular NMR Assignments 7 (1) , pp. 61-64. 10.1007/s12104-012-9378-x |
Wysoczanski, Piotr, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Loveridge, Edric Joel, Williams, Christopher, Whittaker, Sara B.-M., Crump, Matthew P. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2013. 1H, 13C and 15N chemical shift assignments of unliganded Bcl-xL and its complex with a photoresponsive Bak-derived peptide. Biomolecular NMR Assignments 7 (2) , pp. 187-191. 10.1007/s12104-012-9407-9 |
Li, Jian-Xu, Fang, Xin, Zhao, Qin, Ruan, Ju-Xin, Yang, Chang-Qing, Wang, Ling-Jian, Miller, David James, Faraldos, Juan A., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Chen, Xiao-Ya and Zhang, Peng 2013. Rational engineering of plasticity residues of sesquiterpene synthases from 'Artemisia annua': Product specificity and catalytic efficiency. Biochemical Journal 451 (3) , pp. 417-426. 10.1042/BJ20130041 |
Li, Jian‑Xu, Fang, Xin, Zhao, Qin, Ruan, Ju-Xin, Yang, Chang‑Qing, Wang, Ling‑Jian, Miller, David James, Faraldos, Juan A., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Chen, Xiao‑Ya and Zhang, Peng 2013. Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency. Biochemical Journal -London- 451 (3) , pp. 417-426. 10.1042/BJ20130041 |
Chen, Mengbin, Al-Lami, Naeemah, Janvier, Marine, D'Antonio, Edward L., Faraldos, Juan A., Cane, David E., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Christianson, David W. 2013. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry 52 (32) , pp. 5441-5453. 10.1021/bi400691v |
Pickett, John A., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Birkett, Michael A. 2013. The semiochemistry of aphids. Natural Product Reports 30 (10) , pp. 1277-1283. 10.1039/c3np70036d |
van der Kamp, Marc W., Sirirak, Jitnapa, Zurek, Jolanta, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Mulholland, Adrian J. 2013. Conformational change and ligand binding in the aristolochene synthase catalytic cycle. Biochemistry 52 (45) , pp. 8094-8105. 10.1021/bi400898k |
Wysoczanski, Piotr, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Loveridge, Edric Joel, Williams, Christopher, Whittaker, Sara B.-M., Crump, Matthew P. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL. Journal of the American Chemical Society 134 (18) , pp. 7644-7647. 10.1021/ja302390a |
Aros Orellana, Danilo Fernando, Gonzalez, Veronica, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Müller, Carsten Theodor ORCID: https://orcid.org/0000-0003-0455-7132, Rosati, Carlo and Rogers, Hilary Joan ORCID: https://orcid.org/0000-0003-3830-5857 2012. Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. Journal of Experimental Botany 63 (7) , pp. 2739-2752. 10.1093/jxb/err456 |
Miller, David James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Sesquiterpene synthases: Passive catalysts or active players? Natural Product Reports 29 (1) , pp. 60-71. 10.1039/c1np00060h |
Faraldos, Juan A., Miller, David James, Gonzalez, Veronica, Yoosuf-Aly, Fathima Zulfa, Cascón, Oscar, Li, Amang and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. A 1,6-ring closure mechanism for (+)-δ-cadinene synthase? Journal of the American Chemical Society 134 (13) , pp. 5900-5908. 10.1021/ja211820p |
Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Wysoczanski, Piotr, Kneissl, Sabine, Ricci, Antonio, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Design of photocontrolled RNA-binding peptidomimetics. ChemBioChem 13 (4) , pp. 515-519. 10.1002/cbic.201100800 |
Loveridge, Edric Joel, Behiry, Enas Mamdouh, Guo, Jian Nan and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Evidence that a 'dynamic knockout' in Escherichia coli dihydrofolate reductase does not affect the chemical step of catalysis. Nature Chemistry 4 (4) , pp. 292-297. 10.1038/nchem.1296 |
Faraldos, Juan A., Gonzalez, Veronica and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. The role of aristolochene synthase in diphosphate activation. Chemical Communications- Royal Society of Chemistry 48 (26) , pp. 3230-3232. 10.1039/c2cc17588f |
Adams, Sarah Elizabeth, Parr, Christian, Miller, David James, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X 2012. Potent inhibition of Ca2+-dependent activation of calpain-1 by novel mercaptoacrylates. MedChemComm 3 (5) , pp. 566-570. 10.1039/c2md00280a |
Yoosuf-Aly, Zulfa, Faraldos, Juan A., Miller, David James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate. Chemical Communications 48 , pp. 7040-7042. 10.1039/c2cc32883f |
Cascón, Oscar, Touchet, Sabrina, Miller, David James, Gonzalez, Veronica, Faraldos, Juan A. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Chemoenzymatic preparation of germacrene analogues. Chemical Communications 48 (78) , pp. 9702-9704. 10.1039/c2cc35542f |
Faraldos, Juan A., Gonzalez, Veronica, Li, Amang, Yu, Fanglei, Köksal, Mustafa, Christianson, David W. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2012. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. Journal of the American Chemical Society 134 (51) , pp. 20844-20848. 10.1021/ja311022s |
Loveridge, Edric Joel, Tey, Lai-Hock, Behiry, Enas Mamdouh, Dawson, William Michael, Evans, Rhiannon Mari, Whittaker, Sara B.-M., Günther, Ulrich L., Williams, Christopher, Crump, Matthew P. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. The role of large-scale motions in catalysis by dihydrofolate reductase. Journal of the American Chemical Society 133 (50) , pp. 20561-20570. 10.1021/ja208844j |
Faraldos, Juan A., Antonczak, Alicja K., Gonzalez, Veronica, Fullerton, Rebecca, Tippmann, Eric Michael and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Probing eudesmane cation−π interactions in catalysis by aristolochene synthase with non-canonical amino acids. Journal of the American Chemical Society 133 (35) , pp. 13906-13909. 10.1021/ja205927u |
Fricke, Thomas, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Watkins, Catherine Louise, Wiltshire, Marie, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376, Smith, Paul James, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Chemical synthesis of cell-permeable apoptotic peptides from in vivo produced proteins. Bioconjugate Chemistry 22 (9) , pp. 1763-1767. 10.1021/bc200338u |
Loveridge, Edric Joel, Dawson, William Michael, Evans, Rhiannon Mari, Sobolewska, Anna and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Reduced Susceptibility of Moritella profunda Dihydrofolate Reductase to Trimethoprim is Not Due to Glutamate 28. The Protein Journal 30 (8) , pp. 546-548. 10.1007/s10930-011-9361-x |
Faraldos, Juan A. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Inhibition of (+)-Aristolochene Synthase with Iminium Salts Resembling Eudesmane Cation. Organic Letters 13 (5) , pp. 1202-1205. 10.1021/ol2000843 |
Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Effect of pH on Hydride Transfer by Escherichia coli Dihydrofolate Reductase. ChemBioChem 12 (8) , pp. 1258-1262. 10.1002/cbic.201000794 |
Faraldos, Juan A., Gonzalez, Veronica, Senske, Michael and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2011. Templating effects in aristolochene synthase catalysis: elimination versus cyclisation. Organic & Biomolecular Chemistry 9 (20) , pp. 6920-6923. 10.1039/c1ob06184d |
Fricke, Thomas, Mart, Robert J. ORCID: https://orcid.org/0000-0003-2196-5840, Watkins, Catherine Louise, Jones, Arwyn Tomos ORCID: https://orcid.org/0000-0003-2781-8905 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2010. Click chemistry for the generation of cell permeable apoptotic peptides. Drug Discovery Today 15 (23-24) , p. 1088. 10.1016/j.drudis.2010.09.375 |
Tey, Lai-Hock, Loveridge, Edric Joel, Swanwick, Richard, Flitsch, Sabine L. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2010. Highly site-selective stability increases by glycosylation of dihydrofolate reductase. FEBS Journal 277 (9) , pp. 2171-2179. 10.1111/j.1742-4658.2010.07634.x |
Edwards, Wayne Robert, Williams, Abigail J., Morris, Josephine Lydia, Baldwin, Amy Joy ORCID: https://orcid.org/0000-0002-2162-3771, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Jones, Darran Dafydd ORCID: https://orcid.org/0000-0001-7709-3995 2010. Regulation of β-Lactamase activity by remote binding of Heme: functional coupling of unrelated proteins through domain insertion. Biochemistry 49 (31) , pp. 6541-6549. 10.1021/bi100793y |
Loveridge, Edric Joel, Tey, Lai-Hock and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2010. Solvent effects on catalysis by Escherichia coli dihydrofolate reductase. Journal of the American Chemical Society 132 (3) , pp. 1137-1143. 10.1021/ja909353c |
Faraldos, Juan A., Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897 and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2010. Intermediacy of Eudesmane Cation during Catalysis by Aristolochene Synthase. Journal of Organic Chemistry 75 (4) , pp. 1119-1125. 10.1021/jo902397v |
Evans, Rhiannon Mari, Behiry, Enas Mamdouh, Tey, Lai-Hock, Guo, Jiannan, Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2010. Catalysis by Dihydrofolate Reductase from the Psychropiezophile Moritella profunda. ChemBioChem 11 (14) , pp. 2010-2017. 10.1002/cbic.201000341 |
Loveridge, Edric Joel, Behiry, Enas Mamdouh, Swanwick, Richard S. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases. Journal of the American Chemical Society 131 (20) , pp. 6926-6927. 10.1021/ja901441k |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Evans, Rhiannon Mari and Loveridge, Edric Joel 2009. Probing coupled motions in enzymatic hydrogen tunnelling reactions. Biochemical Society Transactions 37 , pp. 349-353. 10.1042/BST0370349 |
Gennadios, Heather A., Gonzalez, Veronica, Di Costanzo, Luigi, Li, Amang, Yu, Fanglei, Miller, David James, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Christianson, David W. 2009. Crystal structure of (+)-δ-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis. Biochemistry 48 (26) , pp. 6175-6183. 10.1021/bi900483b |
Loveridge, Edric Joel, Rodriguez, R. J., Swanwick, Richard S. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. Effect of Dimerization on the Stability and Catalytic Activity of Dihydrofolate Reductase from the Hyperthermophile Thermotoga maritima. Biochemistry 48 (25) , pp. 5922-5933. 10.1021/bi900411a |
Miller, David James, Yu, Fanglei, Knight, David William and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. 6- and 14-Fluoro farnesyl diphosphate: mechanistic probes for the reaction catalysed by aristolochene synthase. Organic & Biomolecular Chemistry 7 (5) , pp. 962-975. 10.1039/b817194g |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. Cystine-based Scaffolds for Functional Miniature Proteins. Moroder, L. and Buchner, J., eds. Oxidative Folding of Peptides and Proteins, London: RSC Publishing, pp. 381-395. (10.1039/9781847559265-00381) |
Loveridge, Edric Joel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. Direct methods for the analysis of quantum-mechanical tunnelling: dihydrofolate reductase. Allemann, Rudolf Konrad and Scrutton, N. S., eds. Quantum Tunnelling in Enzyme-Catalysed Reactions, London: RSC Publishing, pp. 179-198. (10.1039/9781847559975-00179) |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Young, Neil James, Ma, Shuhua, Truhlar, Donald G. and Gao, Jiali 2009. Synthetic Efficiency in Enzyme Mechanisms Involving Carbocations: Aristolochene Synthase [Addition/Correction]. Journal of the American Chemical Society 131 (27) , p. 9600. 10.1021/ja904281h |
Hay, Sam, Evans, Rhiannon Mari, Levy, Colin, Loveridge, Edric Joel, Wang, Xi, Leys, David, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Scrutton, Nigel S. 2009. Are the Catalytic Properties of Enzymes from Piezophilic Organisms Pressure Adapted? ChemBioChem 10 (14) , pp. 2348-2353. 10.1002/cbic.200900367 |
Loveridge, Edric Joel, Maglia, Giovanni and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2009. The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the HyperthermophileThermotoga maritima. ChemBioChem 10 (16) , pp. 2624-2627. 10.1002/cbic.200900465 |
Carpenter, Barry K. ORCID: https://orcid.org/0000-0002-5470-0278 2009. The transition-state theory description of enzyme catalysis for classically activated reactions. Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Scrutton, N. S., eds. Quantum tunnelling in enzyme-catalysed reactions, London: RSC Publishing, pp. 1-17. (10.1039/9781847559975-00001) |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Scrutton, N. S., eds. 2009. Quantum tunnelling in enzyme-catalysed reactions. RSC biomolecular sciences, vol. 18. Cambridge: RSC Publishing. |
Miller, David James, Yu, Fanglei and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. FLUO 14-Study of sesquiterpene cyclization reactions using fluorinated farnesyl diphosphate analogs. Abstracts of Papers of the American Chemical Society 236 |
Shishova, Ekaterina Y., Yu, Fanglei, Miller, David James, Faraldos, Juan A., Zhao, Yuxin X., Coates, Robert M., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Cane, David E. and Christianson, David W. 2008. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. Journal of Biological Chemistry 283 (22) , pp. 15431-15439. 10.1074/jbc.M800659200 |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. Chemical wizardry? The generation of diversity in terpenoid biosynthesis. Pure and Applied Chemistry 80 (8) , pp. 1791-1798. 10.1351/pac200880081791 |
Edwards, W. R., Busse, K., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Jones, Darran Dafydd ORCID: https://orcid.org/0000-0001-7709-3995 2008. Linking the functions of unrelated proteins using a novel directed evolution domain insertion method. Nucleic Acids Research 36 (13) 10.1093/nar/gkn363 |
Fütterer, K., Ravelli, R. B. G., White, S. A., Nicoll, A. J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. Differential specific radiation damage in the CuII-bound and PdII-bound forms of an α-helical foldamer: A case study of crystallographic phasing by RIP and SAD. Acta Crystallographica Section D: Biological Crystallography 64 (3) , pp. 264-272. 10.1107/S0907444907065948 |
Hay, S., Pang, J. Y., Monaghan, P. J., Wang, X., Evans, R. M., Sutcliffe, M. J., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Scrutton, N. S. 2008. Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. ChemPhysChem 9 (11) , pp. 1536-1539. 10.1002/cphc.200800291 |
Loveridge, Edric Joel, Evans, R. M. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. Solvent Effects on Environmentally Coupled Hydrogen Tunnelling During Catalysis by Dihydrofolate Reductase from Thermotoga maritima. Chemistry-a European Journal 14 (34) , pp. 10782-10788. 10.1002/chem.200801804 |
Miller, David James, Gao, Jiali, Truhlar, D. G., Young, Neil James, Gonzalez, Veronica and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti. Organic & Biomolecular Chemistry 6 (13) , pp. 2346-2354. 10.1039/b804198a |
Kneissl, Sabine, Loveridge, Edric Joel, Williams, Christopher, Crump, Matthew P. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2008. Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL. ChemBioChem 9 (18) , pp. 3046-3054. 10.1002/cbic.200800502 |
Yu, Fanglei, Miller, David James and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate. Chemical Communications- Royal Society of Chemistry (40) , pp. 4155-4157. 10.1039/b709562g |
Miller, David James, Yu, Fanglei and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. Aristolochene synthase-catalyzed cyclization of 2-fluorofarnesyl-diphosphate to 2-fluorogermacrene A. Chembiochem 8 (15) , pp. 1819-1825. 10.1002/cbic.200700219 |
Miller, David James, Yu, Fanglei, Young, Neil J and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity. Organic & Biomolecular Chemistry 5 (20) , pp. 3287-3298. 10.1039/b713301b |
Miller, D. J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. myo-Inositol Monophosphatase: A Challenging Target for Mood Stabilising Drugs. Mini-Reviews in Chemistry 7 (2) , pp. 107-113. 10.2174/138955707779802624 |
Pang, Jiayun and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2007. Molecular dynamics simulation of thermal unfolding of Thermatoga maritima DHFR. Physical Chemistry Chemical Physics 9 (6) , pp. 711-718. 10.1039/b611210b |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Young, Neil James, Ma, Shuhua, Truhlar, Donald G. and Gao, Jiali 2007. Synthetic Efficiency in Enzyme Mechanisms Involving Carbocations: Aristolochene Synthase. Journal of the American Chemical Society 129 (43) , pp. 13008-13013. 10.1021/ja0722067 |
Nicoll, Andrew J., Miller, David James, Fütterer, Klaus, Ravelli, Raymond and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2006. Designed high affinity Cu2+ -Binding α-Helical foldamer. Journal of the American Chemical Society 128 (28) , pp. 9187-9193. 10.1021/ja061513u |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Evans, Rhiannon Mari, Tey, Lai-Hock, Maglia, G., Pang, Jiayun, Rodriguez, Robert, Shrimpton, P. J. and Swanwick, Richard S. 2006. Protein motions during catalysis by dihydrofolate reductases. Philosophical Transactions of the Royal Society of London Series B - Biological Sciences 361 (1472) , pp. 1317-1321. 10.1098/rstb.2006.1865 |
Maglia, Giovanni, Swanwick, Richard S., Tey, Lai-Hock and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2006. Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase. Biochemical Journal 394 (1) , pp. 259-265. 10.1042/BJ20051464 |
Pang, Jiayun, Pu, Jingzhi, Gao, Jiali, Truhlar, Donald G. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2006. Hydride Transfer Reaction Catalyzed by Hyperthermophilic Dihydrofolate Reductase Is Dominated by Quantum Mechanical Tunneling and Is Promoted by Both Inter- and Intramonomeric Correlated Motions. Journal of the American Chemical Society 128 (24) , pp. 8015-8023. 10.1021/ja061585l |
Forcat, Silvia and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2006. Stabilisation of transition states prior to and following eudesmane cation in aristolochene synthase. Organic & Biomolecular Chemistry 4 (13) , pp. 2563-2567. 10.1039/b604147g |
Guerrero, Lucia, Smart, Oliver S., Weston, Chris J., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Woolley, G. Andrew 2005. Photochemical Regulation of DNA-Binding Specificity of MyoD. Angewandte Chemie International Edition 44 (47) , pp. 7778-7782. 10.1002/anie.200502666 |
Swanwick, Richard S., Daines, Alison M., Flitsch, Sabine L. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2005. Synthesis of homogenous site-selectively glycosylated proteins. Organic & Biomolecular Chemistry 3 (4) , pp. 572-574. 10.1039/b417133k |
Swanwick, Richard S., Daines, Alison M., Tey, Lai-Hock, Flitsch, Sabine L. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2005. Increased Thermal Stability of Site-Selectively Glycosylated Dihydrofolate Reductase. ChemBioChem 6 (8) , pp. 1338-1340. 10.1002/cbic.200500103 |
Guerrero, Lucia, Smart, Oliver S., Woolley, G. Andrew and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2005. Photocontrol of DNA Binding Specificity of a Miniature Engrailed Homeodomain. Journal of the American Chemical Society 127 (44) , pp. 15624-15629. 10.1021/ja0550428 |
Swanwick, Richard S., Shrimpton, Paul J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Pivotal role of Gly 121 in dihydrofolate reductase from Escherichia coli: the altered structure of a mutant enzyme may form the basis of its diminished datalytic performance. Biochemistry 43 (14) , pp. 4119-4127. 10.1021/bi036164k |
Miller, David James, Bashir-Uddin Surfraz, M., Akhtar, Mahmoud, Gani, David and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Removal of the phosphate group in mechanism-based inhibitors of inositol monophosphatase leads to unusual inhibitory activity. Organic & Biomolecular Chemistry 2 (5) , pp. 671-688. 10.1039/b312808c |
Turner, Elizebeth C., Cureton, Charlotte H., Weston, Chris J., Smart, Oliver S. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Controlling the DNA Binding Specificity of bHLH Proteins through Intramolecular Interactions. Chemistry & Biology 11 (1) , pp. 69-77. 10.1016/j.chembiol.2003.12.015 |
Bashir-Uddin Surfraz, M., Akhtar, Mahmoud and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Bis-benzyl protected 6-amino cyclitols are poisonous to Pd/C catalysed hydrogenolysis of benzyl ethers. Tetrahedron Letters 45 (6) , pp. 1223-1226. 10.1016/j.tetlet.2003.11.130 |
Weston, Chris J., Cureton, Charly H., Calvert, Melanie J., Smart, Oliver S. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. A Stable Miniature Protein with Oxaloacetate Decarboxylase Activity. ChemBioChem 5 (8) , pp. 1075-1080. 10.1002/cbic.200300805 |
Forcat, Silvia and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Dual role for phenylalanine 178 during catalysis by aristolochene synthase. Chemical Communications (18) , pp. 2094-2095. 10.1039/b407932a |
Nicoll, Andrew J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Nucleophilic and general acid catalysis at physiological pH by a designed miniature esterase. Organic & Biomolecular Chemistry 2 (15) , pp. 2175-2180. 10.1039/b404730c |
Nicoll, Andrew J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2004. Miniature proteomics: designing alpha-helical miniature proteins. Recent Research Developments in Chemistry 2 , pp. 227-243. |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Maglia, Giovanni 2003. Evidence for Environmentally Coupled Hydrogen Tunneling during Dihydrofolate Reductase Catalysis. Journal of the American Chemical Society 125 (44) , pp. 13372-13373. 10.1021/ja035692g |
Bashir-Uddin Surfraz, M., Miller, David James., Gani, David and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2003. Product-like inhibitors of inositol monophosphatase. Tetrahedron Letters 44 (41) , pp. 7677-7679. 10.1016/S0040-4039(03)01878-1 |
Shrimpton, Paul, Mullaney, Alex and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2003. Functional role for Tyr 31 in the catalytic cycle of chicken dihydrofolate reductase. Proteins: Structure, Function and Bioinformatics 51 (2) , pp. 216-223. 10.1002/prot.10370 |
Maglia, Giovanni, Javed, Masood H. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2003. Hydride transfer during catalysis by dihydrofolate reductase from Thermotoga maritima. Biochemical Journal 374 (2) , pp. 529-535. 10.1042/BJ20030412 |
Deligeorgopoulou, Athina, Taylor, Susan E., Forcat, Silvia and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2003. Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis. Chemical Communications (17) , pp. 2162-2163. 10.1039/b306867f |
Kohler, Ursina and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2002. Transcription factors. Creighton, T. E., ed. Encyclopedia of Molecular Biology, Oxford: Wiley, (10.1002/047120918X.emb1569) |
Shrimpton, Paul and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2002. Role of water in the catalytic cycle of E. coli dihydrofolate reductase. Protein Science 11 (6) , pp. 1442-1451. 10.1110/ps.5060102 |
Calvert, Melanie J., Ashton, Peter R. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2002. Germacrene A Is a Product of the Aristolochene Synthase-Mediated Conversion of Farnesylpyrophosphate to Aristolochene. Journal of the American Chemical Society 124 (39) , pp. 11636-11641. 10.1021/ja020762p |
Calvert, Melanie J., Taylor, Susan E. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2002. Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphate. Chemical Communications (20) , pp. 2384-2385. 10.1039/b206517g |
Taylor, Susan E., Rutherford, Trevor J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2002. Design of a folded, conformationally stable oxaloacetate decarboxylase. Journal of the Chemical Society, Perkin Transactions 2 2 (4) , pp. 751-755. 10.1039/b200057c |
Taylor, Susan E., Rutherford, Trevor J. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 2001. Design, synthesis and characterisation of a peptide with oxaloacetate decarboxylase activity. Biorganic and Medicinal Chemistry Letters 11 (19) , pp. 2631-2635. 10.1016/S0960-894X(01)00519-4 |
Dezan, C., Meierhans, D., Künne, A. G. E. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1999. Acquisition of myogenic specificity through replacement of one amino acid of MASH-1 and introduction of an additional α-helical turn. Biological Chemistry 380 (6) , pp. 705-710. 10.1515/BC.1999.088 |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1999. DNA-protein binding specificity. Creighton, Thomas E., ed. Encyclopedia of Molecular Biology, Vol. 2. New York: Wiley, pp. 743-745. |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1999. DNA-protein interaction thermodynamics. Creighton, Thomas E., ed. Encyclopedia of Molecular Biology, Vol. 2. New York: Wiley, pp. 745-755. |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1999. MADS-Box proteins. Creighton, Thomas E., ed. Encyclopedia of Molecular Biology, Vol. 3. New York: Wiley, pp. 1430-1431. |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1999. Transcription factors. Creighton, Thomas E., ed. Encyclopedia of Molecular Biology, Vol. 4. New York: Wiley, pp. 2586-2593. |
Sieber, M. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1998. Single chain dimers of MASH-1 bind DNA with enhanced affinity. Nucleic Acids Research 26 (6) , pp. 1408-1413. 10.1093/nar/26.6.1408 |
Künne, Andreas G. E., Sieber, Martin, Meierhans, Daniel and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1998. Thermodynamics of the DNA binding reaction of transcription factor MASH-1. Biochemistry 37 (12) , pp. 4217-4223. 10.1021/bi9725374 |
Meierhans, D. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1998. The N-terminal methionine is a major determinant of the DNA binding specificity of MEF-2C. Journal of Biological Chemistry 273 (40) , pp. 26052-26060. 10.1074/jbc.273.40.26052 |
Sieber, M. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1998. Arginine (348) is a major determinant of the DNA binding specificity of transcription factor E12. Biological Chemistry 379 (6) , pp. 731-735. |
Meierhans, D. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1997. High level expression in soluble form, one step purification, and characterization of the DNA binding domain of MEF-2C. Protein Expression and Purification 11 (3) , pp. 297-303. 10.1006/prep.1997.0795 |
Künne, Andreas G. E. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1997. Covalently linking BHLH subunits of MASH-1 increases specificity of DNA Binding. Biochemistry 36 (5) , pp. 1085-1091. 10.1021/bi962185l |
Meierhans, D., Sieber, M. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1997. High affinity binding of MEF-2C correlates with DNA bending. Nucleic Acids Research 25 (22) , pp. 4537-4544. 10.1093/nar/25.22.4537 |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Egli, M. 1997. DNA recognition and bending. Chemistry & Biology 4 (9) , pp. 643-650. 10.1016/S1074-5521(97)90218-0 |
Künne, A, Meierhans, D. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1996. Basic helix-loop-helix protein MyoD displays modest DNA binding specificity. FEBS Letters 391 (1-2) , pp. 79-83. 10.1016/0014-5793(96)00707-7 |
Meierhans, Daniel, el-Ariss, Chirine, Neuenschwander, Margrit, Sieber, Martin, Stackhouse, Joseph F. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1995. DNA Binding Specificity of the Basic-Helix-Loop-Helix Protein MASH-1. Biochemistry 34 (35) , pp. 11026-11036. 10.1021/bi00035a008 |
Johnsson, Kai, Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Widmer, Hans and Benner, Steven A. 1993. Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides. Nature 365 (6446) , pp. 530-532. 10.1038/365530a0 |
Whiting, J., Marshall, H., Cook, M., Krumlauf, R., Rigby, P. W., Stott, D. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1991. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes & Development 5 (11) , pp. 2048-2059. 10.1101/gad.5.11.2048 |
Hunt, P., Whiting, J., Nonchev, S., Sham, M.-H., Marshall, H., Graham, A., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Rigby, P., Gulisano, M., Faiella, A., Boncinelli, E. and Krumlauf, R. 1991. The branchial Hox code and its implications for gene regulation, patterning of the nervous system and head evolution. Development 113 (S2) , pp. 63-77. |
Johnson, K., Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 and Benner, S. A. 1990. Designed enzymes. Bleasdale, C. and Golding, R., eds. Molecular mechanisms in bioorganic processes, London: Royal Society of Chemistry, pp. 166-187. |
Benner, Steven A. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1989. The return of pancreatic ribonucleases. Trends in Biochemical Sciences 14 (10) , pp. 396-397. 10.1016/0968-0004(89)90282-X |
Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830, Hung, Rebecca and Benner, Steven A. 1988. Stereochemical profile of the dehydrogenases of Drosophila melanogaster. Journal of the American Chemical Society 110 (16) , pp. 5555-5560. 10.1021/ja00224a046 |
Benner, S. A. and Allemann, Rudolf Konrad ORCID: https://orcid.org/0000-0002-1323-8830 1987. Natural Selection, Protein Engineering, and the last Riboorganism: Rational Model Building in Biochemistry. Evolution of Catalytic Function, CSH Symposia on Quantitative Biology, vol. 52. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, pp. 53-63. |