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A novel community driven software for functional enrichment analysis of extracellular vesicles data

Pathan, M., Keerthikumar, S., Chisanga, D., Alessandro, R., Ang, C.-S., Askenase, P., Batagov, A. O., Benito-Martin, A., Camussi, G., Clayton, Aled, Collino, F., Di Vizio, D., Falcon-Perez, J. M., Fonseca, P., Fonseka, P., Fontana, S., Gho, Y. S., Hendrix, A., Nolte-'t Hoen, E., Iraci, N., Kastaniegaard, K., Kislinger, T., Kowal, J., Kurochkin, I. V., Leonardi, T., Liang, Y., Llorente, A., Lunavat, T. R., Maji, S., Monteleone, F., Overbye, A., Panaretakis, T., Patel, T., Peinado, H., Pluchino, S., Principe, S., Ronquist, G., Royo, F., Sahoo, S., Spinelli, C., Stensballe, A., Thery, C., Van Herwijnen, M. J., Wauben, M., Welton, J., Zhao, K. and Mathivanan, S. 2017. A novel community driven software for functional enrichment analysis of extracellular vesicles data. Journal of Extracellular Vesicles 6 , 1321455. 10.1080/20013078.2017.1321455

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Bioinformatics tools are imperative for the in depth analysis of heterogeneous high-throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture “what the community needs in a tool”. Here, we describe a novel community-driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes. Remarkably, with the enthusiastic participation of the community, we were able to implement 90% of the requested features. FunRich enables plugin for extracellular vesicles wherein users can download and analyse data from Vesiclepedia database. By involving researchers early through community needs software development, we believe that comprehensive analysis tools can be developed in various scientific disciplines.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RZ Other systems of medicine
Publisher: Taylor & Francis
ISSN: 2001-3078
Date of First Compliant Deposit: 13 July 2017
Date of Acceptance: 22 February 2017
Last Modified: 18 Oct 2017 11:03

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