Saeed, Hiwa K., Jarman, Paul J., Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim Q., Mckenzie, Luke K., Weinstein, Julia A., Buurma, Niklaas J.  ORCID: https://orcid.org/0000-0003-0260-5057, Smythe, Carl G. W. and Thomas, Jim A.
2017.
Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical, and biological studies.
Angewandte Chemie International Edition
56
(41)
, pp. 12628-12633.
10.1002/anie.201707350
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Abstract
Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | Wiley |
| ISSN: | 1433-7851 |
| Date of First Compliant Deposit: | 31 August 2017 |
| Date of Acceptance: | 18 August 2017 |
| Last Modified: | 02 Dec 2024 11:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/104169 |
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