Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical, and biological studies

Saeed, Hiwa K., Jarman, Paul J., Archer, Stuart, Sreedharan, Sreejesh, Saeed, Ibrahim Q., Mckenzie, Luke K., Weinstein, Julia A., Buurma, Niklaas J. ORCID: https://orcid.org/0000-0003-0260-5057, Smythe, Carl G. W. and Thomas, Jim A. 2017. Homo- and heteroleptic phototoxic dinuclear metallo-intercalators based on RuII(dppn) intercalating moieties: synthesis, optical, and biological studies. Angewandte Chemie International Edition 56 (41) , pp. 12628-12633. 10.1002/anie.201707350

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Abstract

Using a new mononuclear “building block,” for the first time, a dinuclear RuII(dppn) complex and a heteroleptic system containing both RuII(dppz) and RuII(dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence “switch on” DNA light-switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Date of First Compliant Deposit:	31 August 2017
Date of Acceptance:	18 August 2017
Last Modified:	02 Dec 2024 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/104169

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