IFN-α can both protect against and promote the development of Type 1 diabetes

Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 and Wen, Li 2008. IFN-α can both protect against and promote the development of Type 1 diabetes. Annals of the New York Academy of Sciences 1150 (1) , pp. 187-189. 10.1196/annals.1447.031

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Abstract

Viral infection has been hypothesized to be one of the environmental triggers for the development of type 1 diabetes. Infection induces a large amount of interferon-α (IFN-α) produced by dendritic cells and other cells. To test the role of IFN-α in the development of diabetes, we have used three different experimental approaches in both diabetes- prone and -resistant animal models for type 1 diabetes. Our results suggested that a viral mimic or IFN-α can either suppress or promote the development of autoimmune diabetes, depending on the model system. It is likely that IFN-α plays a complex role in the etiology of type 1 diabetes.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Wiley-Blackwell
ISSN:	0077-8923
Last Modified:	03 Nov 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/105283

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