Progressive decline of glucocerebrosidase in aging and Parkinson's disease

Rocha, Emily M., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Park, Eric, Cao, Hongmei, Brown, Eilish, Hallett, Penelope and Isacson, Ole 2015. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology 2 (4) , pp. 433-438. 10.1002/acn3.177

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Abstract

The principal risk factor for developing most adult onset neurodegenerative diseases is aging, with incidence rising significantly after age 50. Despite research efforts, the causes of Parkinson's disease (PD) remain unknown. As neurons age, they show signs of diminished lysosomal and mitochondrial function, including increased oxidative stress and accumulation of misfolded proteins, and these changes become exacerbated PD. We show that activity of the lysosomal hydrolase glucocerebrosidase gradually diminishes with age in the substantia nigra and putamen of healthy controls. This reduction is comparable to glucocerebrosidase activity in GBA1‐mutation carrier PD patients. These data, demonstrate for the first time that an age‐dependent reduction in glucocerebrosidase activity may lower the threshold for developing PD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley-Blackwell
ISSN:	2328-9503
Date of Acceptance:	29 December 2014
Last Modified:	03 Nov 2022 09:51
URI:	https://orca.cardiff.ac.uk/id/eprint/106222

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