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Number of items: 42.

Kors, Suzan, Schuster, Martin, Maddison, Daniel C. ORCID: https://orcid.org/0000-0003-3038-1687, Kilaru, Sreedhar, Schrader, Tina A., Costello, Joseph L., Islinger, Markus, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Schrader, Michael 2024. New insights into the functions of ACBD4/5-like proteins using a combined phylogenetic and experimental approach across model organisms. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1871 , 119843. 10.1016/j.bbamcr.2024.119843
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Townsend, L. N., Clarke, H., Maddison, D., Jones, K. M., Amadio, L., Jefferson, A., Chughtai, U., Bis, D. M., Züchner, S., Allen, N. D., Van der Goes van Naters, W., Peters, O. M. and Smith, G. A. ORCID: https://orcid.org/0000-0003-4332-8383 2023. Cdk12 maintains the integrity of adult axons by suppressing actin remodeling. Cell Death Discovery 9 (1) , 348. 10.1038/s41420-023-01642-4
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Rees, Daniel, Beynon, Amy L., Lelos, Mariah J. ORCID: https://orcid.org/0000-0001-7102-055X, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Roberts, Luke D., Phelps, Lyndsey, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578, Morgan, Alwena H., Brown, Rowan M., Wells, Timothy ORCID: https://orcid.org/0000-0003-3618-0595 and Davies, Jefrey S. 2023. Acyl-ghrelin attenuates neurochemical and motor deficits in the 6-OHDA model of Parkinson’s Disease. Cellular and Molecular Neurobiology 43 , pp. 2377-2384. 10.1007/s10571-022-01282-9
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Smith, Gaynor ORCID: https://orcid.org/0000-0003-4332-8383, Sweeney, Sean T., O’Kane, Cahir J. and Prokop, Andreas 2023. How neurons maintain their axons long-term: an integrated view of axon biology and pathology. Frontiers in Neuroscience 17 , 1236815. 10.3389/fnins.2023.1236815
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Maddison, Daniel C. ORCID: https://orcid.org/0000-0003-3038-1687, Malik, Bilal, Amadio, Leonardo, Bis-Brewer, Dana M., Züchner, Stephan, Peters, Owen M. ORCID: https://orcid.org/0000-0002-6824-0663 and Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 2023. COPI-regulated mitochondria-ER contact site formation maintains axonal integrity. Cell Reports 42 (8) , 112883. 10.1016/j.celrep.2023.112883
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Mattedi, Francesca, Maddison, Daniel ORCID: https://orcid.org/0000-0003-3038-1687, Smith, Gaynor Ann ORCID: https://orcid.org/0000-0003-4332-8383 and Vagnoni, Alessio 2023. Live imaging of mitochondria in the intact fly wing. Cold Spring Harbor Protocol 2023 (2) , 108052. 10.1101/pdb.prot108052
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Maddison, Daniel ORCID: https://orcid.org/0000-0003-3038-1687, Mattedi, Francesca, Vagnoni, Alessio and Smith, Gaynor Ann ORCID: https://orcid.org/0000-0003-4332-8383 2023. Analysis of mitochondrial dynamics in adult drosophila axons. Cold Spring Harbor Protocol 2023 (2) , 107819. 10.1101/pdb.top107819
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Maddison, Daniel ORCID: https://orcid.org/0000-0003-3038-1687, Mattedi, Francesca, Vagnoni, Alessio and Smith, Gaynor Ann ORCID: https://orcid.org/0000-0003-4332-8383 2023. Clonal imaging of mitochondria in the dissected fly wing. Cold Spring Harbor Protocol 2023 (2) , 108051. 10.1101/pdb.prot108051
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Peters, Owen M. ORCID: https://orcid.org/0000-0002-6824-0663, Weiss, Alexandra, Metterville, Jake, Song, Lina, Logan, Robert, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Schwarzschild, Michael A., Mueller, Christian, Brown, Robert H. and Freeman, Marc 2021. Genetic diversity of axon degenerative mechanisms in models of Parkinson's disease. Neurobiology of Disease 155 , 105368. 10.1016/j.nbd.2021.105368
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Lin, Tzu-Huai, Bis-Brewer, Dana M., Sheehan, Amy E., Townsend, Louise N., Maddison, Daniel C. ORCID: https://orcid.org/0000-0003-3038-1687, Züchner, Stephan, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Freeman, Marc R. 2021. TSG101 negatively regulates mitochondrial biogenesis in axons. Proceedings of the National Academy of Sciences 118 (20) , e2018770118. 10.1073/pnas.2018770118
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Precious, Sophie V., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Jaeger, Ines, Lane, Emma L. ORCID: https://orcid.org/0000-0001-8800-3764, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578, Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643, Kelly, Claire M. and Rosser, Anne E. ORCID: https://orcid.org/0000-0002-4716-4753 2020. Dopaminergic progenitors derived from epiblast stem cells function similarly to primary VM-derived progenitors when transplanted into a Parkinson’s disease model. Frontiers in Neuroscience 14 , 312. 10.3389/fnins.2020.00312
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Malik, Bilal R., Maddison, Daniel C. ORCID: https://orcid.org/0000-0003-3038-1687, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Peters, Owen M. ORCID: https://orcid.org/0000-0002-6824-0663 2019. Autophagic and endo-lysosomal dysfunction in neurodegenerative disease. Molecular Brain 12 (1) , 100. 10.1186/s13041-019-0504-x
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Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Lin, Tzu-Huai, Sheehan, Amy E., Van Der Goes Van Naters, Wynand ORCID: https://orcid.org/0000-0002-6808-0161, Neukomm, Lukas J., Graves, Hillary K., Bis-Brewer, Dana M., Zuchner, Stephan and Freeman, Marc R. 2019. Glutathione-S-transferase regulates mitochondrial populations in axons through increased glutathione oxidation. Neuron 103 (1) , 52-65.e6. 10.1016/j.neuron.2019.04.017
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Breger, Ludivine S., Kienle, Korbinian, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Dunnett, Stephen B. ORCID: https://orcid.org/0000-0003-1826-1578 and Lane, Emma L. ORCID: https://orcid.org/0000-0001-8800-3764 2017. Influence of chronic L-DOPA treatment on immune response following allogeneic and xenogeneic graft in a rat model of Parkinson's disease. Brain, Behavior, and Immunity 61 , pp. 155-164. 10.1016/j.bbi.2016.11.014
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Smith, G. A. ORCID: https://orcid.org/0000-0003-4332-8383, Jansson, J., Rocha, E. M., Osborn, T., Hallett, P. J. and Isacson, O. 2016. Fibroblast biomarkers of sporadic Parkinson's Disease and LRRK2 kinase inhibition. Molecular Neurobiology 53 (8) , pp. 5161-5177. 10.1007/s12035-015-9435-4

Lewis, Elizabeth A. and Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 2016. Using Drosophila models of Huntington's disease as a translatable tool. Journal of Neuroscience Methods 265 , pp. 89-98. 10.1016/j.jneumeth.2015.07.026

Rocha, Emily M., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Park, Eric, Cao, Hongmei, Brown, Eilish, Hayes, Melissa A., Beagan, Jonathan, McLean, Jesse R., Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole 2015. Glucocerebrosidase gene therapy prevents α-synucleinopathy of midbrain dopamine neurons. Neurobiology of Disease 82 , pp. 495-503. 10.1016/j.nbd.2015.09.009

Rocha, Emily M., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Park, Eric, Cao, Hongmei, Graham, Anne-Renee, Brown, Eilish, McLean, Jesse R., Hayes, Melissa A., Beagan, Jonathan, Izen, Sarah C., Perez-Torres, Eduardo, Hallett, Penelope J. and Isacson, Ole 2015. Sustained systemic glucocerebrosidase inhibition induces brain α-Synuclein aggregation, microglia and complement C1q activation in mice. Antioxidants and Redox Signaling 23 (6) , pp. 550-564. 10.1089/ars.2015.6307

Rocha, Emily M., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Park, Eric, Cao, Hongmei, Brown, Eilish, Hallett, Penelope and Isacson, Ole 2015. Progressive decline of glucocerebrosidase in aging and Parkinson's disease. Annals of Clinical and Translational Neurology 2 (4) , pp. 433-438. 10.1002/acn3.177

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Rocha, Emily M., Rooney, Thomas, Barneoud, Pascal, McLean, Jesse R., Beagan, Jonathan, Osborn, Teresia, Coimbra, Madeleine, Luo, Yongyi, Hallett, Penelope J. and Isacson, Ole 2015. A nurr1 agonist causes neuroprotection in a Parkinson's Disease lesion model primed with the toll-like receptor 3 dsRNA inflammatory stimulant poly(I:C). PLoS ONE 10 (3) , e0121072. 10.1371/journal.pone.0121072
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Hallett, Penelope J., Deleidi, Michela, Astradsson, Arnar, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Cooper, Oliver, Osborn, Teresia M., Sundberg, Maria, Moore, Michele A., Perez-Torres, Eduardo, Brownell, Anna-Liisa, Schumacher, James M., Spealman, Roger D. and Isacson, Ole 2015. Successful function of Autologous iPSC-derived dopamine neurons following transplantation in a non-human primate model of Parkinson's disease. Cell Stem Cell 16 (3) , pp. 269-274. 10.1016/j.stem.2015.01.018

McLean, Jesse R., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Rocha, Emily M., Osborn, Teresia M., Dib, Samar, Hayes, Melissa A., Beagan, Jonathan A., Brown, Tana B., Lawson, Tristan F.S., Hallett, Penelope J., Robertson, Janice and Isacson, Ole 2014. ALS-associated peripherin spliced transcripts form distinct protein inclusions that are neuroprotective against oxidative stress. Experimental Neurology 261 , pp. 217-229. 10.1016/j.expneurol.2014.05.024

Smith, G. A. ORCID: https://orcid.org/0000-0003-4332-8383, Rocha, E. M., McLean, J. R., Hayes, M. A., Izen, S. C., Isacson, O. and Hallett, P. J. 2014. Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease. Human Molecular Genetics 23 (17) , pp. 4510-4527. 10.1093/hmg/ddu166

McLean, Jesse R., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Rocha, Emily M., Hayes, Melissa A., Beagan, Jonathan A., Hallett, Penelope J. and Isacson, Ole 2014. Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters. 576 , pp. 73-78. 10.1016/j.neulet.2014.05.044

Davies, Sian E., Hallett, Penelope J., Moens, Thomas, Smith, Gaynor ORCID: https://orcid.org/0000-0003-4332-8383, Mangano, Emily, Kim, Hyoung Tae, Goldberg, Alfred L., Liu, Ji-Long, Isacson, Ole and Tofaris, George K. 2014. Enhanced ubiquitin-dependent degradation by Nedd4 protects against α-synuclein accumulation and toxicity in animal models of Parkinson's disease. Neurobiology of Disease 64 , pp. 79-87. 10.1016/j.nbd.2013.12.011
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Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Snyder, Evan Y. 2013. Two cells are better than one: optimizing stem cell survival by co-grafting “helper” cells that offer regulated trophic support. Experimental Neurology 247 , pp. 751-754. 10.1016/j.expneurol.2013.07.003

Peters, Owen Morgan ORCID: https://orcid.org/0000-0002-6824-0663, Shelkovnikova, Tatyana ORCID: https://orcid.org/0000-0003-1367-5309, Tarasova, Tatiana, Springe, Signe, Kukharsky, Michail S., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Brooks, Simon Philip ORCID: https://orcid.org/0000-0001-9853-6177, Kozin, Sergey A., Kotelevtsev, Yury, Bachurin, Sergey O., Ninkina, Natalia ORCID: https://orcid.org/0000-0001-8570-5648 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2013. Chronic administration of dimebon does not ameliorate amyloid-β pathology in 5xFAD transgenic mice. Journal of Alzheimer's Disease 36 (3) , pp. 589-596. 10.3233/JAD-130071

Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2013. Comparison of 6-hydroxydopamine lesions of the substantia nigra and the medial forebrain bundle on a lateralised choice reaction time task in mice. European Journal of Neuroscience 37 (2) , pp. 294-302. 10.1111/ejn.12036

Sundberg, Maria, Bogetofte, Helle, Lawson, Tristan, Jansson, Johan, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Astradsson, Arnar, Moore, Michele, Osborn, Teresia, Cooper, Oliver, Spealman, Roger, Hallett, Penelope and Isacson, Ole 2013. Improved cell therapy protocols for Parkinson's disease based on differentiation efficiency and safety of hESC-, hiPSC-, and non-human primate iPSC-derived dopaminergic neurons. Stem Cells 31 (8) , pp. 1548-152. 10.1002/stem.1415

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Breger, Ludivine S., Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63 (5) , pp. 818-828. 10.1016/j.neuropharm.2012.06.011

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Isacson, Ole and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. The search for genetic mouse models of prodromal Parkinson's disease. Experimental Neurology 237 (2) , pp. 267-273. 10.1016/j.expneurol.2012.06.035

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 2012. Amphetamine-induced rotation in the transplanted hemi-parkinsonian rat - Response to pharmacological modulation. Behavioural Brain Research 232 (2) , pp. 411-415. 10.1016/j.bbr.2012.04.003

Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice I: Motor impairments identify extent of dopamine depletion at three different lesion sites. Behavioural Brain Research 228 (1) , pp. 30-43. 10.1016/j.bbr.2011.11.027

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 2012. Unilateral nigrostriatal 6-hydroxydopamine lesions in mice II: Predicting L-DOPA-induced dyskinesia. Behavioural Brain Research 226 (1) , pp. 281-292. 10.1016/j.bbr.2011.09.025

Smith, Gaynor Ann ORCID: https://orcid.org/0000-0003-4332-8383, Heuer, Andreas, Klein, Alex, Vinh, Ngoc-Nga, Dunnett, Stephen B and Lane, Emma 2012. Amphetamine-induced dyskinesia in the transplanted hemi-Parkinsonian mouse. Journal of Parkinson's Disease 2 , pp. 107-113. 10.3233/JPD-2012-12102

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Precious, Sophie Victoria, Klein, Alexander, Jaeger, Ines, Kelly, Claire, Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764, Li, Meng ORCID: https://orcid.org/0000-0002-4803-4643 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2012. L-dopa and graft-induced dyskinesia in the 6-OHDA-lesioned mouse [Abstract]. Cell Transplantation 21 (4) , p. 792.

Torres, Eduardo Miguel, Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764, Heuer, Andreas ORCID: https://orcid.org/0000-0003-0300-7606, Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Murphy, Ellen M. and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2011. Increased efficacy of the 6-hydroxydopamine lesion of the median forebrain bundle in small rats, by modification of the stereotaxic coordinates. Journal of Neuroscience Methods 200 (1) , pp. 29-35. 10.1016/j.jneumeth.2011.06.012

Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764, Daly, Carl S., Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2011. Context-driven changes in 1-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiology of Disease 42 (1) , pp. 99-107. 10.1016/j.nbd.2011.01.010

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Breger, Ludivine S., Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 and Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 2011. Developments in Graft-Induced Dyskinesia [Abstract]. Cell Transplantation 20 (4) , pp. 584-585.

Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383, Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 and Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578 2011. Graft-Induced Dyskinesia in Transplanted Hemiparkinsonian Mice and Rats: A Pharmacological Manipulation [Abstract]. Cell Transplantation 20 (4) , p. 585.

Smith, Gaynor ORCID: https://orcid.org/0000-0003-4332-8383 2011. Optimisation and mechanistic insights of dyskinesia in rodent models of Parkinson’s disease. PhD Thesis, Cardiff University.
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Lane, Emma Louise ORCID: https://orcid.org/0000-0001-8800-3764 and Smith, Gaynor A. ORCID: https://orcid.org/0000-0003-4332-8383 2010. Understanding graft-induced dyskinesia. Regenerative Medicine 5 (5) , pp. 787-797. 10.2217/rme.10.42

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