Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons

Carriba, Paulina and Davies, Alun M. 2017. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. eLife 6 , e30442. 10.7554/eLife.30442

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (27MB) | Preview

Abstract

Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in Cd40-/- mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed in excitatory and inhibitory neurons cultured from Cd40-/- mice and were rescued by soluble CD40. The changes in excitatory and inhibitory neurons cultured from Cd40-/- mice were mimicked in neurons of Cd40+/+ mice by treatment with soluble CD40L and were dependent on PKC-β and PKC-γ, respectively. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Funders: Wellcome Trust
Date of First Compliant Deposit: 20 November 2017
Date of Acceptance: 6 November 2017
Last Modified: 17 Mar 2021 02:41
URI: http://orca.cardiff.ac.uk/id/eprint/106749

Citation Data

Cited 12 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics