CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons

Carriba, Paulina and Davies, Alun M. ORCID: https://orcid.org/0000-0001-5841-8176 2017. CD40 is a major regulator of dendrite growth from developing excitatory and inhibitory neurons. eLife 6 , e30442. 10.7554/eLife.30442

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Abstract

Dendrite size and morphology are key determinants of the functional properties of neurons and neural circuits. Here we show that CD40, a member of the TNF receptor superfamily, is a major regulator of dendrite growth and elaboration in the developing brain. The dendrites of hippocampal excitatory neurons were markedly stunted in Cd40-/- mice, whereas those of striatal inhibitory neurons were much more exuberant. These striking and opposite phenotypic changes were also observed in excitatory and inhibitory neurons cultured from Cd40-/- mice and were rescued by soluble CD40. The changes in excitatory and inhibitory neurons cultured from Cd40-/- mice were mimicked in neurons of Cd40+/+ mice by treatment with soluble CD40L and were dependent on PKC-β and PKC-γ, respectively. These results suggest that CD40-activated CD40L reverse signalling has striking and opposite effects on the growth and elaboration of dendrites among major classes of brain neurons by PKC-dependent mechanisms.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Additional Information:	This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Publisher:	eLife Sciences Publications
ISSN:	2050-084X
Funders:	Wellcome Trust
Date of First Compliant Deposit:	20 November 2017
Date of Acceptance:	6 November 2017
Last Modified:	05 May 2023 07:25
URI:	https://orca.cardiff.ac.uk/id/eprint/106749

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