Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner

Walzl, G, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Marshall, B. G, Edwards, L CARDIFF??, Openshaw, P. J, Shaw, R. J and Hussell, T 2003. Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infection and Immunity 71 (6) , pp. 3384-3391. 10.1128/IAI.71.6.3384-3391.2003

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Abstract

Some common childhood infections appear to prevent the development of atopy and asthma. In some Mycobacterium bovis BCG-vaccinated populations, strong delayed-type hypersensitivity responses to mycobacterial antigens are associated with a reduced risk of atopy. Although BCG exposure decreases allergen-induced lung eosinophilia in animal models, little attention has been given to the effect of immunity to BCG on responses against live pathogens. We used the murine Cryptococcus neoformans infection model to investigate whether prior BCG infection can alter such responses. The present study shows that persistent pulmonary BCG infection of C57BL/6 mice induced an increase in gamma interferon, a reduction in interleukin-5, and a decrease in lung eosinophilia during subsequent Cryptococcus infection. This effect was long lasting, depended on the presence of live bacteria, and required persistence of mycobacterial infection in the lung. Reduction of eosinophilia was less prominent after infection with a mutant BCG strain (DeltahspR), which was rapidly cleared from the lungs. These observations have important implications for the development of vaccines designed to prevent Th2-mediated disease and indicate that prior lung BCG vaccination can alter the pattern of subsequent host inflammation

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Adoptive Transfer;Animals;BCG Vaccine/immunology*;CD4-Positive T-Lymphocytes/immunology;CD8-Positive T-Lymphocytes/immunology;Cryptococcosis/pathology*;Female;Flow Cytometry;Interferon-gamma/physiology*;Interleukin-4/biosynthesis;Interleukin-5/biosynthesis;Lung/pathology;Mice;Mice, Inbred ;C57BL Pulmonary Eosinophilia/prevention & control*;Th2 Cells/immunology; Vaccination;
Publisher:	American Society for Microbiology
ISSN:	0019-9567
Date of Acceptance:	20 March 2003
Last Modified:	03 Nov 2022 10:10
URI:	https://orca.cardiff.ac.uk/id/eprint/107147

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