Browse by Current Cardiff authors

Al-Talib, Mohammed, Dimonte, Sandra and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2024. Mucosal T-cell responses to chronic viral infections: Implications for vaccine design. Cellular & Molecular Immunology 21 , pp. 982-998. 10.1038/s41423-024-01140-2

Bliss, Carly M., Hulin-Curtis, Sarah L., Williams, Marta, Marusková, Mahulena, Davies, James A. ORCID: https://orcid.org/0000-0003-3569-4500, Statkute, Evelina, Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Stack, Louise, Kerstetter, Lucas, Kerr-Jones, Lauren E., Milward, Kate, Russell, Gabrielle, George, Sarah J., Badder, Luned M., Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182, Coughlan, Lynda, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Parker, Alan L. ORCID: https://orcid.org/0000-0002-9302-1761 2024. A pseudotyped adenovirus serotype 5 vector with serotype 49 fiber knob is an effective vector for vaccine and gene therapy applications. Molecular Therapy - Methods and Clinical Development 32 (3) , 101308. 10.1016/j.omtm.2024.101308

Amratia, Pragati S., Kerr-Jones, Lauren E., Chapman, Lucy, Marsden, Morgan, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2024. Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection. mBio 15 (8) , e03152-23. 10.1128/mbio.03152-23

Hulin-Curtis, Sarah, Geary, James, MacLachlan, Bruce, Altmann, Danny, Baillon, Laury, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, Greenshields-Watson, Alex, Hesketh, Sophie, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Jones, Ian, Lauder, Sarah, Mason, Georgina, Smart, Kathryn, Scourfield, Oliver, Scott, Jake, Sukhova, Ksenia, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Wall, Aaron, Rizkallah, Pierre ORCID: https://orcid.org/0000-0002-9290-0369, Barclay, Wendy, Gallimore, Awen ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 2024. A targeted single mutation in influenza A virus universal epitope transforms immunogenicity and protective immunity via CD4+ T cell activation. Cell Reports 43 (6) , 114259. 10.1016/j.celrep.2024.114259

Whiteside, Sarah K., Grant, Francis M., Alvisi, Giorgia, Clarke, James, Tang, Leqi, Imianowski, Charlotte J., Zhang, Baojie, Evans, Alexander C., Wesolowski, Alexander J., Conti, Alberto G., Yang, Jie, Lauder, Sarah N., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Dooley, James, Burton, Oliver, Liston, Adrian, Alloisio, Marco, Voulaz, Emanuele, Langhorne, Jean, Okkenhaug, Klaus, Lugli, Enrico and Roychoudhuri, Rahul 2023. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Science Immunology 8 (90) , eabo5558. 10.1126/sciimmunol.abo5558

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Chudakov, Dmitriy M, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R ORCID: https://orcid.org/0000-0002-9512-5337 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 , e79165. 10.7554/eLife.79165

Jessop, Z. M., Gibson, J., Lim, J. Y., Jovic, T. H., Combellack, E., Dobbs, T. D., Carter, K., Hiles, S., Islam, S., Healy, B., Humphreys, I. ORCID: https://orcid.org/0000-0002-9512-5337, Eccles, R. ORCID: https://orcid.org/0000-0001-9492-2062, Hutchings, H. A. and Whitaker, I. S. 2022. A study protocol for a double-blind randomised placebo-controlled trial evaluating the efficacy of carrageenan nasal and throat spray for COVID-19 prophylaxis—ICE-COVID. Trials 23 (1) , 782. 10.1186/s13063-022-06685-z

Clement, M. ORCID: https://orcid.org/0000-0002-9280-5281, Forbester, J. L., Marsden, M., Sabberwal, P., Sommerville, M. S., Wellington, D., Dimonte, S., Clare, S., Harcourt, K., Yin, Z., Nobre, L., Antrobus, R., Jin, B., Chen, M., Makvandi-Nejad, S., Lindborg, J. A., Strittmatter, S. M., Weekes, M. P., Stanton, R. J. ORCID: https://orcid.org/0000-0002-6799-1182, Dong, T. and Humphreys, I. R. ORCID: https://orcid.org/0000-0002-9512-5337 2022. IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses. Nature Communications 13 (1) , 5294. 10.1038/s41467-022-32587-4

Asderakis, Argiris ORCID: https://orcid.org/0000-0001-6859-2020, Khalid, Usman, Koimtzis, Georgios, Ponsford, Mark J., Szabo, Laszlo, Chalklin, Christopher, Bramhall, Kathryn, Grant, Leanne, Moat, Stuart J., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Jolles, Stephen R. 2022. An analysis of serological response and infection outcomes following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 vaccines in kidney and kidney pancreas transplants. Transplantation 106 (7) , pp. 1421-1429. 10.1097/tp.0000000000004105

Saud, Zack, Ponsford, Mark, Bentley, Kirsten ORCID: https://orcid.org/0000-0002-6619-2098, Cole, Jade M, Pandey, Manish, Jolles, Stephen, Fegan, Chris ORCID: https://orcid.org/0000-0001-9685-0621, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Wise, Matt P and Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182 2022. Mechanically ventilated patients shed high titre live SARS-CoV2 for extended periods from both the upper and lower respiratory tract. Clinical Infectious Diseases 75 (1) , e82-e88. 10.1093/cid/ciac170

Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Sabberwal, Pragati, Williamson, James C., Greenwood, Edward J.D., Crozier, Thomas WM, Zelek, Wioleta, Seow, Jeffrey, Graham, Carl, Huettner, Isabella, Edgeworth, Jonathan D., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Morgan, Paul B. ORCID: https://orcid.org/0000-0003-4075-7676, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Merrick, Blair, Doores, Katie, Wilson, Sam J., Lehner, Paul J., Wang, Eddie C.Y. ORCID: https://orcid.org/0000-0002-2243-4964 and Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182 2022. SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies. eLife 11 10.7554/eLife.74489

Ponsford, Mark J., Burton, Ross J., Smith, Leitchan, Khan, Palwasha Y., Andrews, Robert, Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Tan, Laura, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Babolhavaeji, Farbod, Artemiou, Andreas ORCID: https://orcid.org/0000-0002-7501-4090, Pandey, Manish, Jolles, Stephen R. A. and Underwood, Jonathan ORCID: https://orcid.org/0000-0001-6963-2821 2022. Examining the utility of extended laboratory panel testing in the emergency department for risk stratification of patients with COVID-19: a single-centre retrospective service evaluation. Journal of Clinical Pathology 75 (4) , pp. 255-262. 10.1136/jclinpath-2020-207157

Ponsford, Mark J., Jefferies, Rhys, Davies, Chris, Farewell, Daniel ORCID: https://orcid.org/0000-0002-8871-1653, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Jolles, Stephen, Fairbairn, Sara, Lewis, Keir, Menzies, Daniel, Benjamin, Amit, Thaivalappil, Favas, Williams, Chris and Barry, Simon M. 2021. Burden of nosocomial COVID-19 in Wales: results from a multicentre retrospective observational study of 2508 hospitalised adults. Thorax 76 (12) , pp. 1246-1249. 10.1136/thoraxjnl-2021-216964

Dimonte, Sandra, Gimeno-Brias, Silvia, Marsden, Morgan, Chapman, Lucy, Sabberwal, Pragati, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2021. Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses. Immunology 164 (2) , pp. 279-291. 10.1111/imm.13368

Ponsford, Mark J., Ward, Tom J. C., Stoneham, Simon M., Dallimore, Clare M., Sham, Davina, Osman, Khalid, Barry, Simon M., Jolles, Stephen, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Farewell, Daniel ORCID: https://orcid.org/0000-0002-8871-1653 2021. A systematic review and meta-analysis of inpatient mortality associated with nosocomial and community COVID-19 exposes the vulnerability of immunosuppressed adults. Frontiers in Immunology 12 , 744696. 10.3389/fimmu.2021.744696

Ponsford, Mark J., Shillitoe, Benjamin M.J., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Gennery, Andrew R. and Jolles, Stephen 2021. COVID-19 and X-linked agammaglobulinemia (XLA) - insights from a monogenic antibody deficiency. Current Opinion in Allergy and Clinical Immunology 10.1097/ACI.0000000000000792

Humphreys, I. R. ORCID: https://orcid.org/0000-0002-9512-5337 and Godkin, A. J. ORCID: https://orcid.org/0000-0002-1910-7567 2021. Reply to a scientific basis for anxiety about the emergence of resistant strains of Covid-19. QJM: An International Journal of Medicine 114 (7) 10.1093/qjmed/hcab056

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Forbester, Jessica, Marsden, Morgan, Sabberwal, Pragati, Wellington, Danielle, Dimonte, Sandra, Clare, Simon, Harcourt, Katherine, Yin, Zixi, Nobre, Luis, Antrobus, Robin, Jin, Boquan, Chen, Meixin, Makvandi-Nejad, Shokouh, Lindborg, Jane, Strittmatter, Stephen, Weekes, Michael, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Dong, Tao and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2021. IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses. [Online]. bioRxiv. Available at: https://doi.org/10.1101/2021.07.23.453513

Wellington, Dannielle, Yin, Zixi, Abdel-Haq, Adi, Zhang, Liwei, Forbester, Jessica, Kite, Kerry, Rajapaksa, Ushani, Laurenson-Schafer, Henry, Makvandi-Nejad, Shokouh, Jin, Boquan, Bowes, Emma, Manoharan, Krishnageetha, Maldonado-Perez, David, Verrill, Clare, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Dong, Tao 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3) , pp. 742-745. 10.1002/eji.202048706

Forbester, Jessica L. and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2021. Genetic influences on viral-induced cytokine responses in the lung. Mucosal Immunology 14 , pp. 14-25. 10.1038/s41385-020-00355-6

Lucchesi, Davide, Coleby, Rachel, Pontarini, Elena, Prediletto, Edoardo, Rivellese, Felice, Hill, David G., Derrac Soria, Alicia, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Sutcliffe, Nurhan, Tappuni, Anwar R., Pitzalis, Costantino, Jones, Gareth W. ORCID: https://orcid.org/0000-0001-7297-9711 and Bombardieri, Michele 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9) , pp. 1559-1570. 10.1002/art.41289

Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2020. Elevated interleukin‐6, interleukin‐10 and neutrophil : lymphocyte ratio as identifiers of severe coronavirus disease 2019 [Editorial]. Immunology 160 (3) , pp. 221-222. 10.1111/imm.13225

O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Thomas, David ORCID: https://orcid.org/0000-0001-7319-5820, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Murphy, Robert C., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Wakelam, Michael J. O., Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Wise, Matt P., Bosch, Albert and Sattar, Syed A. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) , zqaa002. 10.1093/function/zqaa002

De Trez, Carl, Stijlemans, Benoit, Bockstal, Viki, Cnops, Jennifer, Korf, Hannelie, Van Snick, Jacques, Caljon, Guy, Muraille, Eric, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Boon, Louis, Van Ginderachter, Jo A. and Magez, Stefan 2020. A critical Blimp-1-dependent IL-10 regulatory pathway in T cells protects from a lethal pro-inflammatory cytokine storm during acute experimental Trypanosoma brucei Infection. Frontiers in Immunology 11 , 1085. 10.3389/fimmu.2020.01085

Forbester, Jessica L., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wellington, Dannielle, Yeung, Amy, Dimonte, Sandra, Marsden, Morgan, Chapman, Lucy, Coomber, Eve L., Tolley, Charlotte, Lees, Emily, Hale, Christine, Clare, Simon, Udalova, Irina, Dong, Tao, Dougan, Gordon and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2020. IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models. Journal of Virology 94 (9) , e00121-20. 10.1128/JVI.00121-20

Shelkovnikova, Tatyana A. ORCID: https://orcid.org/0000-0003-1367-5309, An, Haiyan, Skelt, Lucy, Tregoning, John S., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Buchman, Vladimir L. ORCID: https://orcid.org/0000-0002-7631-8352 2019. Antiviral immune response as a trigger of FUS proteinopathy in amyotrophic lateral sclerosis. Cell Reports 29 (13) , 4496-4508.e4. 10.1016/j.celrep.2019.11.094

Singhania, Akul, Graham, Christine M., Gabryšová, Leona, Moreira-Teixeira, Lúcia, Stavropoulos, Evangelos, Pitt, Jonathan M., Chakravarty, Probir, Warnatsch, Annika, Branchett, William J., Conejero, Laura, Lin, Jing-Wen, Davidson, Sophia, Wilson, Mark S., Bancroft, Gregory, Langhorne, Jean, Frickel, Eva, Sesay, Abdul K., Priestnall, Simon L., Herbert, Eleanor, Ioannou, Marianna, Wang, Qian, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Dodd, Jonathan, Openshaw, Peter J. M., Mayer-Barber, Katrin D., Jankovic, Dragana, Sher, Alan, Lloyd, Clare M., Baldwin, Nicole, Chaussabel, Damien, Papayannopoulos, Venizelos, Wack, Andreas, Banchereau, Jacques F., Pascual, Virginia M. and O'Garra, Anne 2019. Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases. Nature Communications 10 , 2887. 10.1038/s41467-019-10601-6

Thompson, Aiysha, Davies, Luke C., Liao, Chia-Te, da Fonseca, Diogo M., Griffiths, James S., Andrews, Robert, Jones, Adam V., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Brown, Gordon D., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and Orr, Selinda J. 2019. The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors. PLoS Pathogens 15 (6) , e1007850. 10.1371/journal.ppat.1007850

Smith, S. E., Busse, D. C., Binter, S., Weston, S., Diaz Soria, C., Laksono, B. M., Clare, S., Van Nieuwkoop, S., Van den Hoogen, B. G., Clement, M. ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, M., Humphreys, I. R. ORCID: https://orcid.org/0000-0002-9512-5337, Marsh, M., de Swart, R. L., Wash, R. S., Tregoning, J. S. and Kellam, P. 2019. Interferon-induced Transmembrane Protein 1 restricts replication of virus that enter cells via the plasma membrane. Journal of Virology 93 (6) , e02003-18. 10.1128/JVI.02003-18

McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3) , pp. 943-955. 10.4049/jimmunol.1701757

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2019. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Frontiers in Immunology 10 , 78. 10.3389/fimmu.2019.00078

Gimeno Brias, Silvia, Marsden, Morgan, Forbester, Jessica, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Brandt, Cordelia, Harcourt, Katherine, Kane, Leanne, Chapman, Lucy, Clare, Simon and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2018. Interferon lambda is required for interferon gamma-expressing NK cell responses but does not afford antiviral protection during acute and persistent murine cytomegalovirus infection. PLoS ONE 13 (5) , e0197596. 10.1371/journal.pone.0197596

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Sebastian, Sarah 2018. Novel viral vectors in infectious diseases. Immunology 153 (1) , pp. 1-9. 10.1111/imm.12829

Rai, Taranjit Singh, Glass, Mandy, Cole, John J., Rather, Mohammad I., Marsden, Morgan, Neilson, Matthew, Brock, Claire, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Everett, Roger D. and Adams, Peter D. 2017. Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Nucleic Acids Research 45 (20) , pp. 11673-11683. 10.1093/nar/gkx771

Sowerby, John M., Thomas, David C., Clare, Simon, Espéli, Marion, Guerrero, Jose A., Hoenderdos, Kim, Harcourt, Katherine, Marsden, Morgan, Abdul-Karim, Juneid, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Antrobus, Robin, Umrania, Yagnesh, Barton, Philippa R., Flint, Shaun M., Juss, Jatinder K., Condliffe, Alison M., Lyons, Paul A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Chilvers, Edwin R., Ouwehand, Willem H., Dougan, Gordon and Smith, Kenneth G. C. 2017. NBEAL2 is required for neutrophil and NK cell function and pathogen defense. Journal of Clinical Investigation 127 (9) , pp. 3521-3526. 10.1172/JCI91684

Stacey, Maria A., Clare, Simon, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Smith, Sarah E., Wash, Rachael S., Gimeno Brias, Silvia, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoe, Ferlin, Walter, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Kellam, Paul and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4) , pp. 1463-1474. 10.1172/JCI84889

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050

Perks, William V., Singh, Ravinder K., Jones, Gareth W., Twohig, Jason P., Williams, Anwen S. ORCID: https://orcid.org/0000-0001-6118-020X, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Simon A. and Wang, Eddie C. Y. ORCID: https://orcid.org/0000-0002-2243-4964 2016. Death Receptor 3 promotes chemokine directed leukocyte recruitment in acute resolving inflammation and is essential for pathological development of mesothelial fibrosis in chronic disease. American Journal of Pathology 186 (11) , pp. 2813-2823. 10.1016/j.ajpath.2016.07.021

Liao, Chia-Te, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke C., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Tyrrell, Victoria J., O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Topley, Nicholas, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528

Patin, Emmanuel, Jones, Adam V., Thompson, Aiysha, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Liao, Chia-Te, Griffiths, James S., Wallace, Leah, Bryant, Clare E., Lang, Roland, Rosenstiel, Philip, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Gareth Wyn and Orr, Selinda Jane 2016. IL-27 induced by Select Candida spp. via TLR7/NOD2 signaling and IFN-β production inhibits fungal clearance. The Journal of Immunology 197 (1) , pp. 208-221. 10.4049/jimmunol.1501204

Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J. and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 , 00211. 10.3389/fimmu.2016.00211

Mohammed, Rebar N., Watson, H. Angharad, Vigar, Miriam, Ohme, Julia, Thomson, Amanda, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908 2016. L-selectin is essential for delivery of activated CD8+ T cells to virus-infected organs for protective immunity. Cell Reports 14 (4) , pp. 760-771. 10.1016/j.celrep.2015.12.090

Stack, Gabrielle, Jones, Emma, Marsden, Morgan, Stacey, Maria A., Snelgrove, Robert J., Lacaze, Paul, Jacques, Laura C., Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Hussell, Tracy, Wilkinson, Gavin W. G. ORCID: https://orcid.org/0000-0002-5623-0126, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2015. CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue. PLoS Pathogens 11 (2) , e1004641. 10.1371/journal.ppat.1004641

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, Luke A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) , 419. 10.1186/s13075-014-0419-y

Stacey, Maria A., Marsden, Morgan, Pham N., Tu Anh, Clare, Simon, Dolton, Garry, Stack, Gabrielle, Jones, Emma, Klenerman, Paul, Gallimore, Awen M. ORCID: https://orcid.org/0000-0001-6675-7004, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Snelgrove, Robert J., Lawley, Trevor D., Dougan, Gordon, Benedict, Chris A., Jones, Simon A., Wilkinson, Gavin W. G. ORCID: https://orcid.org/0000-0002-5623-0126 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2014. Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV. Cell Host and Microbe 15 (4) , pp. 471-483. 10.1016/j.chom.2014.03.003

Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Jones, Gareth W. ORCID: https://orcid.org/0000-0001-7297-9711, McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S. ORCID: https://orcid.org/0000-0003-3768-9940, Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily ORCID: https://orcid.org/0000-0002-9745-3246, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D. ORCID: https://orcid.org/0000-0003-3768-9940, Williams, Geraint T. ORCID: https://orcid.org/0000-0003-3768-9940, Davies, Simon J., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Jenkins, Brendan J., Topley, Nicholas and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1) , pp. 40-50. 10.1016/j.immuni.2013.10.022

Segrott, Jeremy ORCID: https://orcid.org/0000-0001-6215-0870, Rothwell, Heather Ann, Murphy, Simon ORCID: https://orcid.org/0000-0003-3589-3681, Morgan-Trimmer, Sarah ORCID: https://orcid.org/0000-0001-5226-9595, Scourfield, Jonathan Bryn ORCID: https://orcid.org/0000-0001-6218-8158, Holliday, Joanne, Thomas, Claire, Gillespie, David ORCID: https://orcid.org/0000-0002-6934-2928, Roberts, Zoe Elizabeth Sara, Foxcroft, David, Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631, Reed, Hayley ORCID: https://orcid.org/0000-0002-3388-8902, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Moore, Laurence Anthony Russell 2014. Fidelity of implementation of the Strengthening Families Programme 10-14 UK in Wales UK: a mixed-method process evaluation within a randomised controlled trial. Presented at: 7th European Public Health Conference, Glasgow, Scotland,, 19-22 November 2014.

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, L. A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3) , p. 267. 10.1016/j.cyto.2013.06.105

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wooldridge, Linda, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp. 43-44.

Pembroke, Thomas ORCID: https://orcid.org/0000-0002-2600-2034, Rees, Ian W., Gallagher, Kathleen, Jones, Emma, Mizen, Paul Edward, Navruzov, Timur, Freedman, Andrew Robert, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 and Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 2012. Rapid early innate control of hepatitis C virus during IFN-α treatment compromises adaptive CD4+T-cell immunity. European Journal of Immunology 42 (9) , pp. 2383-2394. 10.1002/eji.201142072

Twohig, Jason Peter, Marsden, Morgan, Cuff, Simone ORCID: https://orcid.org/0000-0002-0546-3579, Ferdinand, John R., Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Perks, William Victor, Al-Shamkhani, Aymen, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 2012. The death receptor 3/TL1A pathway is essential for efficient development of antiviral CD4+ and CD8+ T-cell immunity. The FASEB Journal 26 (8) , pp. 3575-3586. 10.1096/fj.11-200618

Stack, Gabrielle, Stacey, Maria A. and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2012. Herpesvirus exploitation of host immune inhibitory pathways. Viruses 4 (12) , pp. 1182-1201. 10.3390/v4081182

Greenhill, Claire, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , p. 48. 10.1093/rheumatology/kes117

Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Nowell, Mari Ann, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1) , p. 158. 10.1111/j.1365-2567.2011.03534.x

Stacey, Maria A., Marsden, Morgan, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964, Wilkinson, Gavin William Grahame ORCID: https://orcid.org/0000-0002-5623-0126 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2011. IL-10 restricts activation-induced death of NK cells during acute murine cytomegalovirus infection. The Journal of Immunology 187 (6) , pp. 2944-2952. 10.4049/jimmunol.1101021

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Lee, Seung-Woo, Jones, Morgan, Loewendorf, Andrea, Gostick, Emma, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Benedict, Chris A., Ware, Carl F. and Croft, Michael 2010. Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8+ T cells. European Journal of Immunology 40 (10) , pp. 2762-2768. 10.1002/eji.200940256

Jones, Morgan, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Wynn, Katherine, Stacey, Maria A., Quigley, Maire F., Gostick, Emma, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2010. IL-10 restricts memory T cell inflation during cytomegalovirus infection. The Journal of Immunology 185 (6) , pp. 3583-3592. 10.4049/jimmunol.1001535

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Loewendorf, Andrea, De Trez, Carl, Schneider, Kirsten, Benedict, Chris A., Munks, Michael W., Ware, Carl F. and Croft, Michael 2007. OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T cells: a CD4 dependent mechanism. Journal of Immunology 179 , pp. 2195-2202.

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, De Trez, Carl, Kinkade, April, Benedict, Chris A., Croft, Michael and Ware, Carl F. 2007. Cytomegalovirus exploits IL-10-mediated immune regulation in the salivary glands. Journal of Experimental Medicine 204 (5) , pp. 1217-25. 10.1084/jem.20062424

Cheung, T. C., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Potter, K. G., Norris, P. S., Shumway, H. M., Tran, B. R., Patterson, G., Jean-Jacques, R., Yoon, M., Spear, P. G., Murphy, K. M., Lurain, N. S., Benedict, C. A. and Ware, C. F. 2005. Evolutionarily divergent herpesviruses modulate T cell activation by targeting the herpesvirus entry mediator cosignaling pathway. Proceedings of the National Academy of Sciences 102 (47) , pp. 13218-13223. 10.1073/pnas.0506172102

Stewart, G. R, Newton, S. M, Wilkinson, K. A, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Murphy, H. N, Robertson, B. D, Wilkinson, R. J and Young, D. B 2005. The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Molecular Microbiology 55 (4) , pp. 1127-1137. 10.1111/j.1365-2958.2004.04450.x

Hale, C, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Hussell, T, Bowe, F, Clare, S, Pickard, D, Preston, A, Del Giudice, G and Dougan, G 2004. Mucosal immunisation of murine neonates using whole cell and acellular Pertussis vaccines. Vaccine 22 (27-28) , pp. 3595-3602. 10.1016/j.vaccine.2004.03.039

Hussell, T, Snelgrove, R, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 and Williams, A. E 2004. Co-stimulation: novel methods for preventing viral-induced lung inflammation. Trends in Molecular Medicine 10 (8) , pp. 379-386. 10.1016/j.molmed.2004.06.006

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Walzl, Gerhard, Hussell, Tracy and Hill, Sue 2003. A critical role for OX40 in T cell-mediated immunopathology during lung viral infection. Journal of Experimental Medicine 198 (8) , pp. 1237-42. 10.1084/jem.20030351

Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Edwards, L CARDIFF??, Walzl, G, Rae, A. J, Dougan, G, Hill, S and Hussell, T 2003. OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia. Journal of Immunology 170 (12) , pp. 6125-6132. 10.4049/jimmunol.170.12.6125

Walzl, G, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Marshall, B. G, Edwards, L CARDIFF??, Openshaw, P. J, Shaw, R. J and Hussell, T 2003. Prior exposure to live Mycobacterium bovis BCG decreases Cryptococcus neoformans-induced lung eosinophilia in a gamma interferon-dependent manner. Infection and Immunity 71 (6) , pp. 3384-3391. 10.1128/IAI.71.6.3384-3391.2003

Dearman, R.J, Filby, A, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 and Kimber, I 2002. Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides. Journal of Applied Toxicology 22 (5) , pp. 317-325. 10.1002/jat.865

Dearman, R.J, Warbrick, E.V, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 and Kimber, I 2000. Characterization in mice of the immunological properties of five allergenic acid anhydrides. Journal of Applied Toxicology 20 (3) , pp. 221-230. 10.1002/(SICI)1099-1263(200005/06)20:3<221::AID-JAT651>3.0.CO;2-#