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Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis

Choy, Ernest H S and Calabrese, Leonard H 2017. Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis. Rhuematology 57 (11) , pp. 1885-1895. 10.1093/rheumatology/kex391

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RA is a chronic, systemic, autoimmune disease characterized by inflammation and degradation of the joints, causing significant negative impact on quality of life. In addition to joint disease, symptoms and co-morbidities associated with RA—namely pain, fatigue and mood disorders—are often as debilitating as the disease itself. The pro-inflammatory cytokine IL-6 plays a critical role in RA-associated pathology. However, a greater understanding of the translational effects of IL-6 outside of the immune system is needed. This review discusses our current understanding of emerging aspects of IL-6 in RA-associated pain, fatigue and mood disorders such as depression and anxiety. This review also describes the clinical effects of IL-6 inhibition on these symptoms and co-morbidities in patients with RA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Oxford University Press
ISSN: 1462-0324
Date of First Compliant Deposit: 5 January 2018
Date of Acceptance: 19 September 2017
Last Modified: 10 Jan 2019 15:11

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