Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis

Choy, Ernest H S ORCID: https://orcid.org/0000-0003-4459-8609 and Calabrese, Leonard H 2017. Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis. Rhuematology 57 (11) , pp. 1885-1895. 10.1093/rheumatology/kex391

Preview

PDF - Published Version Available under License Creative Commons Attribution Non-commercial. Download (289kB) | Preview

Abstract

RA is a chronic, systemic, autoimmune disease characterized by inflammation and degradation of the joints, causing significant negative impact on quality of life. In addition to joint disease, symptoms and co-morbidities associated with RA—namely pain, fatigue and mood disorders—are often as debilitating as the disease itself. The pro-inflammatory cytokine IL-6 plays a critical role in RA-associated pathology. However, a greater understanding of the translational effects of IL-6 outside of the immune system is needed. This review discusses our current understanding of emerging aspects of IL-6 in RA-associated pain, fatigue and mood disorders such as depression and anxiety. This review also describes the clinical effects of IL-6 inhibition on these symptoms and co-morbidities in patients with RA.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Oxford University Press
ISSN:	1462-0324
Date of First Compliant Deposit:	5 January 2018
Date of Acceptance:	19 September 2017
Last Modified:	05 May 2023 09:16
URI:	https://orca.cardiff.ac.uk/id/eprint/107932

Citation Data

Cited 61 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item