Choy, Ernest H S  ORCID: https://orcid.org/0000-0003-4459-8609 and Calabrese, Leonard H
2017.
Neuroendocrine and neurophysiological effects of interleukin 6 in rheumatoid arthritis.
Rhuematology
57
(11)
, pp. 1885-1895.
10.1093/rheumatology/kex391
|
Preview |
PDF
- Published Version
Available under License Creative Commons Attribution Non-commercial. Download (289kB) | Preview |
Abstract
RA is a chronic, systemic, autoimmune disease characterized by inflammation and degradation of the joints, causing significant negative impact on quality of life. In addition to joint disease, symptoms and co-morbidities associated with RA—namely pain, fatigue and mood disorders—are often as debilitating as the disease itself. The pro-inflammatory cytokine IL-6 plays a critical role in RA-associated pathology. However, a greater understanding of the translational effects of IL-6 outside of the immune system is needed. This review discusses our current understanding of emerging aspects of IL-6 in RA-associated pain, fatigue and mood disorders such as depression and anxiety. This review also describes the clinical effects of IL-6 inhibition on these symptoms and co-morbidities in patients with RA.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Publisher: | Oxford University Press |
| ISSN: | 1462-0324 |
| Date of First Compliant Deposit: | 5 January 2018 |
| Date of Acceptance: | 19 September 2017 |
| Last Modified: | 05 May 2023 09:16 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/107932 |
Citation Data
Cited 61 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
 |
Edit Item |
Altmetric
Altmetric