Rad, Ellie, Murray, James and Tee, Andrew  ORCID: https://orcid.org/0000-0002-5577-4631
2018.
Oncogenic signalling through mechanistic Target Of Rapamycin (mTOR): a driver of metabolic transformation and cancer progression.
Cancers
10
(1)
10.3390/cancers10010005
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Abstract
Throughout the years, research into signalling pathways involved in cancer progression has led to many discoveries of which mechanistic target of rapamycin (mTOR) is a key player. mTOR is a master regulator of cell growth control. mTOR is historically known to promote cell growth by enhancing the efficiency of protein translation. Research in the last decade has revealed that mTOR’s role in promoting cell growth is much more multifaceted. While mTOR is necessary for normal human physiology, cancer cells take advantage of mTOR signalling to drive their neoplastic growth and progression. Oncogenic signal transduction through mTOR is a common occurrence in cancer, leading to metabolic transformation, enhanced proliferative drive and increased metastatic potential through neovascularisation. This review focuses on the downstream mTOR-regulated processes that are implicated in the “hallmarks” of cancer with focus on mTOR’s involvement in proliferative signalling, metabolic reprogramming, angiogenesis and metastasis
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | MDPI AG |
| ISSN: | 2072-6694 |
| Date of First Compliant Deposit: | 15 January 2018 |
| Date of Acceptance: | 28 December 2017 |
| Last Modified: | 06 May 2023 13:47 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/108173 |
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