Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Browse by Current Cardiff authors

[up] Up a level
Number of items: 53.

McPhail, Darius K., Alzahrani, Mohammad A.M., Martin, Katie R., Calver, Brian L., Harwood, Adrian J. ORCID: https://orcid.org/0000-0003-3124-5169, MacKeigan, Jeffrey P., Davies, David M. and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2025. Loss of tuberous sclerosis complex 2 confers inflammation via dysregulation of nuclear factor kappa-light-chain-enhancer of activated B cells. Journal of Inflammation 22 (1) , 38. 10.1186/s12950-025-00464-8
file

Jones, Rachel-Ann ORCID: https://orcid.org/0000-0001-9792-7483, Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561, Champion, Jesse, Doubleday, Peter F., Claessens, Tijs, Jalali, Zahra, Seifan, Sara, Perry, Iain, Giles, Peter ORCID: https://orcid.org/0000-0003-3143-6854, Harrison, Oliver, Coull, Barry J., Houweling, Arjan C., Pause, Arnim, Ballif, Bryan A. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2025. Characterizing the tumor suppressor activity of FLCN in Birt-Hogg-Dubé syndrome through transcriptiomic and proteomic analysis. Oncogene 44 , pp. 1833-1843. 10.1038/s41388-025-03325-z
file

Mantoan Ritter, Laura, Annear, Nicholas M. P., Baple, Emma L., Ben-Chaabane, Leila Y., Bodi, Istvan, Brosson, Lauren, Cadwgan, Jill E., Coslett, Bryn, Crosby, Andrew H., Davies, D. Mark, Daykin, Nicola, Dedeurwaerdere, Stefanie, Dühring Fenger, Christina, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Elmslie, Frances V., Girodengo, Marie, Hambleton, Sophie, Jansen, Anna C., Johnson, Simon R., Kearley, Kelly C., Kingswood, John C., Laaniste, Liisi, Lachlan, Katherine, Latchford, Andrew, Madsen, Ralitsa R., Mansour, Sahar, Mihaylov, Simeon R., Muhammed, Louwai, Oliver, Claire, Pepper, Tom, Rawlins, Lettie E., Schim van der Loeff, Ina, Siddiqui, Ata, Takhar, Pooja, Tatton-Brown, Katrina, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Tibarewal, Priyanka, Tye, Charlotte, Ultanir, Sila K., Vanhaesebroeck, Bart, Zare, Benjamin, Pal, Deb K. and Bateman, Joseph M. 2025. mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node. Orphanet Journal of Rare Diseases 20 (256) 10.1186/s13023-025-03740-1
file

Bhaoighill, Muireann Ní, Falcón-Pérez, Juan M., Royo, Félix, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Webber, Jason ORCID: https://orcid.org/0000-0003-4772-3014 and Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 2023. Tuberous Sclerosis Complex cell-derived EVs have an altered protein cargo capable of regulating their microenvironment and have potential as disease biomarkers. Journal of Extracellular Vesicles 12 (6) , 12336. 10.1002/jev2.12336
file

Baskaran, Pranetha, Mihaylov, Simeon R., Vinsland, Elin, Shah, Kriti, Granat, Lucy, Ultanir, Sila K., Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Murn, Jernej and Bateman, Joseph M. 2023. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. Journal of Biological Chemistry 299 (1) , 102788. 10.1016/j.jbc.2022.102788
file

Champion, Jesse D., Dodd, Kayleigh M., Lam, Hilaire C., Alzahrani, Mohammad A.M., Seifan, Sara, Rad, Ellie, Scourfield, David Oliver, Fishel, Melissa L., Calver, Brian L., Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Henske, Elizabeth P., Davies, D. Mark, Kelley, Mark R. and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2022. Drug inhibition of redox factor-1 restores hypoxia-driven changes in tuberous sclerosis complex 2 deficient cells. Cancers 14 (24) , 6195. 10.3390/cancers14246195
file

Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Rai, Pavandeep, Miwa, Satomi, Draman, Mohd, Rees, D Aled ORCID: https://orcid.org/0000-0002-1165-9092, Haridas, Anjana S., Morris, Daniel S., Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Ludgate, Marian, Turnbull, Doug M. and Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462 2021. The role of mitochondria-linked fatty-acid uptake-driven adipogenesis in Graves’ Orbitopathy. Endocrinology 162 (12) , bqab188. 10.1210/endocr/bqab188
file

Vinsland, Elin, Baskaran, Pranetha, Mihaylov, Simeon R., Hobbs, Carl, Wood, Hannah, Bouybayoune, Ihssane, Shah, Kriti, Houart, Corinne, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Murn, Jernej, Fernandes, Cathy and Bateman, Joseph M. 2021. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Scientific Reports 11 (1) , 16299. 10.1038/s41598-021-95286-y
file

Gampala, Silpa, Shah, Fenil, Zhang, Chi, Rhodes, Steven D., Babb, Olivia, Grimard, Michelle, Wireman, Randall S., Rad, Ellie, Calver, Brian, Bai, Ren-Yuan, Staedtke, Verena, Hulsey, Emily L., Saadatzadeh, M. Reza, Pollok, Karen E., Tong, Yan, Smith, Abbi E., Clapp, D. Wade, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Kelley, Mark R. and Fishel, Melissa L. 2021. Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours. British Journal of Cancer 124 (9) , pp. 1566-1580. 10.1038/s41416-021-01270-8
filefile

Xie, Jianling, Shen, Kaikai ORCID: https://orcid.org/0000-0002-3891-7231, Jones, Ashley T., Yang, Jian ORCID: https://orcid.org/0000-0003-2631-4553, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Shen, Ming Hong ORCID: https://orcid.org/0000-0002-3891-7231, Yu, Mengyuan, Irani, Swati, Wong, Derick, Merrett, James E., Lenchine, Roman V., De Poi, Stuart, Jensen, Kirk B., Trim, Paul J., Snel, Marten F., Kamei, Makoto, Martin, Sally Kim, Fitter, Stephen, Tian, Shuye, Wang, Xuemin, Butler, Lisa M., Zannettino, Andrew C. W. and Proud, Christopher G. 2021. Reciprocal signaling between mTORC1 and MNK2 controls cell growth and oncogenesis. Cellular and Molecular Life Sciences 78 (1) , 249–270. 10.1007/s00018-020-03491-1
file

Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Evans, Anna ORCID: https://orcid.org/0000-0002-2430-811X, von Ruhland, Chris, Draman, Mohd Shazli, Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Vincent, Amy E., Berlinguer-Palmini, Rolando, Rees, D. Aled ORCID: https://orcid.org/0000-0002-1165-9092, Haridas, Anjana S, Morris, Dan, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631, Ludgate, Marian, Turnbull, Doug M., Karpe, Fredrik and Dayan, Colin M. ORCID: https://orcid.org/0000-0002-6557-3462 2020. Distinctive features of orbital adipose tissue (OAT) in Graves' orbitopathy. International Journal of Molecular Sciences 21 (23) , 9145. 10.3390/ijms21239145
file

McEneaney, Lauren J. and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2019. Finding a cure for tuberous sclerosis complex: from genetics through to targeted drug therapies. Advances in Genetics 103 , pp. 91-118. 10.1016/bs.adgen.2018.11.003
file

Bruning, Ulrike, Morales-Rodriguez, Francisco, Kalucka, Joanna, Goveia, Jermaine, Taverna, Federico, Queiroz, Karla C.S., Dubois, Charlotte, Cantelmo, Anna Rita, Chen, Rongyuan, Loroch, Stefan, Timmerman, Evy, Caixeta, Vanessa, Bloch, Katarzyna, Conradi, Lena-Christin, Treps, Lucas, Staes, An, Gevaert, Kris, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Dewerchin, Mieke, Semenkovich, Clay F., Impens, Francis, Schilling, Birgit, Verdin, Eric, Swinnen, Johannes V., Meier, Jordan L., Kulkarni, Rhushikesh A., Sickmann, Albert, Ghesquière, Bart, Schoonjans, Luc, Li, Xuri, Mazzone, Massimiliano and Carmeliet, Peter 2018. Impairment of angiogenesis by fatty acid synthase inhibition Involves mTOR malonylation. Cell Metabolism 28 (6) , pp. 866-880. 10.1016/j.cmet.2018.07.019
file

Johnson, Charlotte E. ORCID: https://orcid.org/0000-0003-1954-5142, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Seifan, Sara, McCann, Henry D., Hay, Trevor, Parfitt, Geraint J. ORCID: https://orcid.org/0000-0002-8704-7906, Jones, Ashley T., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Shen, Ming H. ORCID: https://orcid.org/0000-0002-3891-7231, Sampson, Julian R. ORCID: https://orcid.org/0000-0002-2902-2348, Errington, Rachel J. ORCID: https://orcid.org/0000-0002-8016-4376, Davies, D. Mark and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2018. Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir−bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death. Oncogene 37 , pp. 5913-5925. 10.1038/s41388-018-0381-2
file

McCann, Henry, Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, Errington, Rachel ORCID: https://orcid.org/0000-0002-8016-4376, Davies, D. Mark, Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2018. Energy stress-mediated cytotoxicity in tuberous sclerosis complex 2-deficient cells with nelfinavir and mefloquine treatment. Cancers 10 (10) , 375. 10.3390/cancers10100375
file

Murray, James and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2018. Mechanistic Target of Rapamycin (mTOR) in the cancer setting. Cancers 10 (6) , p. 168. 10.3390/cancers10060168
file

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2018. The target of rapamycin and mechanisms of cell growth. International Journal of Molecular Sciences 19 (3) , pp. 880-892. 10.3390/ijms19030880
file

Rad, Ellie, Murray, James and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2018. Oncogenic signalling through mechanistic Target Of Rapamycin (mTOR): a driver of metabolic transformation and cancer progression. Cancers 10 (1) 10.3390/cancers10010005
file

Johnson, Charlotte E. ORCID: https://orcid.org/0000-0003-1954-5142 and Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 2017. Exploiting cancer vulnerabilities: mTOR, autophagy, and homeostatic imbalance. Essays in Biochemistry 61 (6) , pp. 699-710. 10.1042/EBC20170056
file

Dunlop, Elaine A ORCID: https://orcid.org/0000-0002-9209-7561, Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, Wiltshire, Marie, Errington, Rachel Jane ORCID: https://orcid.org/0000-0002-8016-4376 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2017. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively. Oncotarget 10.18632/oncotarget.16232
file

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2016. The benefits of exploiting rare genetic disorders to better understand human health and disease. Seminars in Cell & Developmental Biology 52 , pp. 1-2. 10.1016/j.semcdb.2016.03.007
file

Carroll, Bernadette, Maetzel, Dorothea, Maddocks, Oliver D. K., Otten, Gisela, Ratcliff, Matthew, Smith, Graham R., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Passos, João F., Davies, Owen R., Jaenisch, Rudolf, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Sarkar, Sovan and Korolchuk, Viktor I. 2016. Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity. eLife 5 , -. 10.7554/eLife.11058
file

Rad, Ellie and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2016. Neurofibromatosis type 1: Fundamental insights into cell signalling and cancer. Seminars in Cell & Developmental Biology 52 , pp. 39-46. 10.1016/j.semcdb.2016.02.007
file

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348, Pal, Deb K. and Bateman, Joseph M. 2016. The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex. Seminars in Cell and Developmental Biology 52 , pp. 12-20. 10.1016/j.semcdb.2016.01.040

Upadhyaya, Meena, Winston, Jincy, Radcliffe, E., Mort, Matthew, Dodd, Kayleigh, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, McDyer, F., Moore, S., Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484 and Thomas, L. 2015. Correlation of copy number changes and gene expression in neurofibromatosis1-associated malignant peripheral nerve sheath tumours [Abstract]. Pediatric Blood and Cancer 62 (S4) , S152-S152. 10.1002/pbc.25715

Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Ji, Q. H. J., Ruge, Fiona, Lane, C., Morris, D., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462 and Ludgate, Marian Elizabeth 2015. Reversal of pathological features of Graves' orbitopathy by activation of forkhead transcription factors, FOXOs. Journal of Clinical Endocrinology & Metabolism 101 (1) , pp. 114-122. 10.1210/jc.2015-2932

Rad, Ellie, Dodd, Kayleigh M., Thomas, Laura E. ORCID: https://orcid.org/0000-0002-8621-5285, Upadhyaya, Meena and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2015. STAT3 and HIF1 signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors. Molecular Cancer Research 13 (7) , p. 1149. 10.1158/1541-7786.MCR-14-0182
file

Dodd, K. M., Yang, J. ORCID: https://orcid.org/0000-0003-2631-4553, Shen, M. H. ORCID: https://orcid.org/0000-0002-3891-7231, Sampson, J. R. ORCID: https://orcid.org/0000-0002-2902-2348 and Tee, A. R. ORCID: https://orcid.org/0000-0002-5577-4631 2015. mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3. Oncogene 34 (17) , pp. 2239-2250. 10.1038/onc.2014.164
file

Thomas, Laura E. ORCID: https://orcid.org/0000-0002-8621-5285, Winston, Jincy, Rad, Ellie, Mort, Matthew, Dodd, Kayleigh M., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, McDyer, Fionnuala, Moore, Stephen, Cooper, David Neil ORCID: https://orcid.org/0000-0002-8943-8484 and Upadhyaya, Meena 2015. Evaluation of copy number variation and gene expression in neurofibromatosis type-1-associated malignant peripheral nerve sheath tumours. Human Genomics 9 (1) , 3. 10.1186/s40246-015-0025-3
file

Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. mTOR and autophagy: a dynamic relationship governed by nutrients and energy. Seminars in Cell and Developmental Biology 36 , pp. 121-129. 10.1016/j.semcdb.2014.08.006

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. Fundamental for life: mTOR orchestrates developing biological systems. Seminars in Cell & Developmental Biology 36 , pp. 66-67. 10.1016/j.semcdb.2014.10.001

Johnson, Charlotte ORCID: https://orcid.org/0000-0003-1954-5142, Hunt, David K., Wiltshire, Marie, Herbert, Terry P., Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348, Errington, Rachel J. ORCID: https://orcid.org/0000-0002-8016-4376, Davies, David Mark and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. Endoplasmic reticulum stress and cell death in mTORC1-overactive cells is induced by nelfinavir and enhanced by chloroquine. Molecular Oncology 9 (3) , pp. 675-688. 10.1016/j.molonc.2014.11.005
file

Zhang, Lei ORCID: https://orcid.org/0000-0003-3536-8692, Grennan-Jones, Fiona, Draman, M.S., Lane, C., Morris, D., Dayan, Colin ORCID: https://orcid.org/0000-0002-6557-3462, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Ludgate, Marian Elizabeth 2014. Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy. Journal of Clinical Endocrinology & Metabolism 99 (7) , E1183-E1190. 10.1210/jc.2013-4182

Yan, Ming, Gingras, Marie-Claude, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Nouët, Yann, Dupuy, Fanny, Jalali, Zahra, Possik, Elite, Coull, Barry J., Kharitidi, Dmitri, Dydensborg, Anders Bondo, Faubert, Brandon, Kamps, Miriam, Sabourin, Sylvie, Preston, Rachael S., Davies, David Mark, Roughead, Taren, Chotard, Laëtitia, van Steensel, Maurice A.M., Jones, Russell, Tee, Andrew R. ORCID: https://orcid.org/0000-0002-5577-4631 and Pause, Arnim 2014. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. Journal of Clinical Investigation 124 (6) , pp. 2640-2650. 10.1172/JCI71749

Dunlop, Elaine ORCID: https://orcid.org/0000-0002-9209-7561, Seifan, Sara, Claessens, Tijs, Behrends, Christian, Kamps, Miriam A.F., Rozycka, Ewelina, Kemp, Alain J., Nookala, Ravi K., Blenis, John, Coull, Barry J., Murray, James T., van Steensel, Maurice A.M., Wilkinson, Simon and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2014. FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation. Autophagy 10 (10) , pp. 1749-1760. 10.4161/auto.29640
file

Luijten, Monique N. H., Basten, Sander G., Claessens, Tijs, Vernooij, Marigje, Scott, Claire L., Janssen, Renske, Easton, Jennifer A., Kamps, Miriam A. F., Vreeburg, Maaike, Broers, Jos L. V., van Geel, Michel, Menko, Fred H., Harbottle, Richard P., Nookala, Ravi K., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Land, Stephen C., Giles, Rachel H., Coull, Barry J. and van Steensel, Maurice A. M. 2013. Birt–Hogg–Dubé syndrome is a novel ciliopathy. Human Molecular Genetics 22 (21) , pp. 4383-4397. 10.1093/hmg/ddt288

Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa and Walker, Cheryl Lyn 2013. A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. Nature Cell Biology 15 (10) , pp. 1186-1195. 10.1038/ncb2822

Dhingra, R, Gang, H, Wang, Y, Biala, A, Aviv, Y, Margulets, V, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Kirshenbaum, L 2013. Bidirectional regulation of nuclear factor- B and mammalian target of rapamycin signaling functionally links Bnip3 gene repression and cell survival of ventricular myocytes. Circulation: Heart Failure 6 (2) , pp. 335-343. 10.1161/CIRCHEARTFAILURE.112.000061

Tripathi, Durga N., Chowdhury, Rajdeep, Trudel, Laura J., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Slack, Rebecca S., Walker, Cheryl Lyn and Wogan, Gerald N. 2013. Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proceedings of the National Academy of Sciences of the United States of America 110 (32) , E2950-E2957. 10.1073/pnas.1307736110

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Pause, Arnim 2012. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Familial Cancer 12 (3) , pp. 367-372. 10.1007/s10689-012-9576-9

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Hunt, David K., Acosta-Jaquez, Hugo A., Fingar, Diane C. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7 (7) , pp. 737-747. 10.4161/auto.7.7.15491

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Land, Stephen C, Davies, Peter A., Martins, Nicole, Stuart, Helen, McKee, Shane, Kingswood, Chris, Saggar, Anand, Corderio, Isabel, Medeira, Ana Maria Duarte, Kingston, Helen, Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348, Davies, David Mark and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. Determining the pathogenicity of patient-derived TSC2 mutations by functional characterization and clinical evidence. European Journal of Human Genetics 19 (7) , pp. 789-795. 10.1038/ejhg.2011.38

Preston, Rachael S., Philp, A., Claessens, T., Gijezen, L., Dydensborg, A. B., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Harper, Katy T., Brinkhuizen, T., Menko, F. H., Davies, David Mark, Land, S. C., Pause, A., Baar, K., van Steensel, M. A. M. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2011. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene 30 (10) , pp. 1159-1173. 10.1038/onc.2010.497

Scott, C. L., Walker, D. J., Cwiklinski, E., Tait, C., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Land, S. C. 2010. Control of HIF-1α and vascular signaling in fetal lung involves cross talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. AJP: Lung Cellular and Molecular Physiology 299 (4) , L455-L471. 10.1152/ajplung.00348.2009

Soliman, G. A., Acosta-Jaquez, H. A., Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Ekim, B., Maj, N. E., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Fingar, D. C. 2010. mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action. Journal of Biological Chemistry 285 (11) , pp. 7866-7879. 10.1074/jbc.M109.096222

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561, Dodd, Kayleigh M., Seymour, Lyndsey A. and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2009. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. Cellular Signalling 21 (7) , pp. 1073-1084. 10.1016/j.cellsig.2009.02.024

Baird, Fiona E., Bett, Kevin J., MacLean, Catherine, Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Hundal, Harinder. S. and Taylor, Peter M. 2009. Tertiary active transport of amino acids reconstituted by coexpression of System A and L transporters in Xenopus oocytes. American Journal of Physiology. Endocrinology and Metabolism 297 (3) , E822-E829. 10.1152/ajpendo.00330.2009

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Sampson, Julian Roy ORCID: https://orcid.org/0000-0002-2902-2348 and Cheadle, Jeremy Peter ORCID: https://orcid.org/0000-0001-9453-8458 2009. Tuberous sclerosis complex. Schwab, Manfred, ed. Encyclopedia of Cancer. 2nd ed, Springer,

Dunlop, Elaine A. ORCID: https://orcid.org/0000-0002-9209-7561 and Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 2009. Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms. Cellular Signalling 21 (6) , pp. 827-835. 10.1016/j.cellsig.2009.01.012

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Manning, Brendan D., Roux, Philippe P., Cantley, Lewis C. and Blenis, John 2003. Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Current Biology 13 (15) , pp. 1259-1268. 10.1016/S0960-9822(03)00506-2

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Fingar, Diane C., Manning, Brendan D., Kwiatkowski, David J., Cantley, Lewis C. and Blenis, John 2002. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proceedings of the National Academy of Sciences 99 (21) , pp. 13571-13576. 10.1073/pnas.202476899

Manning, Brendan D., Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631, Logsdon, M. Nicole, Blenis, John and Cantley, Lewis C. 2002. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Molecular Cell 10 (1) , pp. 151-162. 10.1016/S1097-2765(02)00568-3

Tee, Andrew ORCID: https://orcid.org/0000-0002-5577-4631 and Proud, C. G. 2002. Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif. Molecular and Cellular Biology 22 (6) , pp. 1674-1683. 10.1128/MCB.22.6.1674-1683.2002

This list was generated on Thu Oct 23 12:08:22 2025 BST.


Maintained by Cardiff University IT