Tang, Hiu Kwan Carolyn, Lee, Doreen Yin Hui, Thompson, Ian, Ingram, John R. ORCID: https://orcid.org/0000-0002-5257-1142, Stone, Natalie and Patel, Girish K. 2017. Delayed and localized pemphigus vulgaris after breast cancer radiotherapy. The Breast Journal 23 (6) , pp. 747-749. 10.1111/tbj.12910 |
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Abstract
Breast cancer treatment involving ionizing radiation causes characteristic radiation dermatitis in the majority of patients. The DNA damaging effects of radiation can rarely predispose to primary inflammatory dermatoses, such as pemphigus vulgaris. In such cases, the disease presents with all the hallmarks of the primary dermatosis, but the eruption is limited to the field of irradiation and is often amenable to treatment. In contrast, occurrence of generalized pemphigus vulgaris in this setting may mean cancer recurrence. The mechanism by which radiotherapy induces localized disease remains unknown, but there is likely a loss of self-tolerance which maybe coupled to antigen exposure.
Item Type: | Article |
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Date Type: | Published Online |
Status: | Published |
Schools: | Biosciences Medicine European Cancer Stem Cell Research Institute (ECSCRI) |
Publisher: | Wiley |
ISSN: | 1075-122X |
Date of First Compliant Deposit: | 24 January 2018 |
Date of Acceptance: | 2 November 2016 |
Last Modified: | 23 Nov 2024 04:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/108436 |
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