Atrial natriuretic peptide inhibits the release of endothelium-derived relaxing factor from blood vessels of the rabbit

Hogan, J. C., Warden-Smith, Jeremy, Richards, A. C. and Lewis, Malcolm John 1989. Atrial natriuretic peptide inhibits the release of endothelium-derived relaxing factor from blood vessels of the rabbit. European Journal of Pharmacology 165 (1) , pp. 129-134. 10.1016/0014-2999(89)90778-4

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Abstract

We investigated the effects of atrial natriuretic peptide (ANP) on release of endothelium-derived relaxing factor (EDRF) from rabbit aorta and central ear artery using inhibition of platelet aggregation and vascular smooth muscle relaxation respectively as measures of EDRF activity. ANP at concentrations greater than 10(-9) M inhibited carbachol-induced EDRF release from rabbit aorta and acetylcholine-induced EDRF release from the central ear artery. These findings are consistent with previous observations that 8-bromo cyclic GMP inhibits EDRF release from rabbit aorta and ANP inhibits release of EDRF from cultured endothelial cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Medicine Pharmacy
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	Endothelium-derived relaxing factor (EDRF); Atrial natriuretic peptide (ANP); Aorta; Central ear artery; (Rabbit)
Publisher:	Elsevier
ISSN:	0014-2999
Last Modified:	17 Mar 2021 02:34
URI:	https://orca.cardiff.ac.uk/id/eprint/10869

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