3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors

Lovell, Peter J., Blaney, Frank E., Goodacre, Caroline J., Scott, Claire M., Smith, Paul W., Starr, Kathryn R., Thewlis, Kevin M., Vong, Antonio K.K., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Watson, Jeannette M. 2006. 3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors. Bioorganic and Medicinal Chemistry Letters 17 (4) , pp. 1033-1036. 10.1016/j.bmcl.2006.11.031

Full text not available from this repository.

Abstract

Investigation of halogen substitution in lead compound 1 has led to the identification of analogues which combine high affinity for 5-HT1A receptors and potent serotonin reuptake inhibitory activity. Several compounds show an improved selectivity over 5-HT1B and 5-HT1D receptors and a superior pharmacokinetic profile in the rat.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Medicine
Uncontrolled Keywords:	5-HT1A, SSRI, Benzoxazinone
Publisher:	Elsevier
ISSN:	0960-894X
Date of Acceptance:	12 November 2006
Last Modified:	23 Oct 2022 13:01
URI:	https://orca.cardiff.ac.uk/id/eprint/109405

Citation Data

Cited 18 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item