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Number of items: 108.

Henderson, Scott, Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus, Godoi, Paulo, de Sousa, Roberta Ruela, Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2024. Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases. European Journal of Medicinal Chemistry 269 , 16292. 10.1016/j.ejmech.2024.116292
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Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-san, Tsang, Shun-Wa, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Chow, King-Lau, Sung, Joseph Jao-yiu and Sze-Lok Cheng, Alfred 2023. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience 26 (10) , 107626. 10.1016/j.isci.2023.107626
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Derudas, Marco, O’Reilly, Molly, Kirkwood, Nerissa K., Kenyon, Emma J., Grimsey, Sybil, Kitcher, Siân R., Workman, Shawna, Bull, James C., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2023. Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives. Frontiers in Cell and Developmental Biology 11 , 1247324. 10.3389/fcell.2023.1247324
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Thomas, Bedwyr, Lewis, Lois, Jones, Dyfyr and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2023. Central nervous system targeted protein degraders. Biomolecules 13 (8) , 1164. 10.3390/biom13081164
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Collins, Ross, Lee, Hyunah, Jones, Dyfyr, Elkins, Jonathan M., Gillespie, Jason A., Thomas, Carys, Baldwin, Alex G. ORCID: https://orcid.org/0000-0002-7126-5220, Jones, Kimberley, Waters, Loren, Paine, Marie, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Grubisha, Olivera ORCID: https://orcid.org/0000-0003-1067-1230 and Foley, David W. ORCID: https://orcid.org/0000-0001-8449-4754 2022. Comparative analysis of small-molecule limk1/2 inhibitors: chemical synthesis, biochemistry, and cellular activity. Journal of Medicinal Chemistry 10.1021/acs.jmedchem.2c00751
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Koulouris, Chloe R., Gardiner, Sian E., Harris, Tessa K., Elvers, Karen T., Mark Roe, S., Gillespie, Jason A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Grubisha, Olivera ORCID: https://orcid.org/0000-0003-1067-1230, Nicholls, Robert A., Atack, John R. and Bax, Benjamin D. 2022. Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Communications Biology 5 (1) , 346. 10.1038/s42003-022-03264-5
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Scott, Fiona, Fala, Angela M., Takarada, Jessica E., Ficu, Mihaela P., Pennicott, Lewis E., Reuillon, Tristan D., Couñago, Rafael M., Massirer, Katlin B., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2022. Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorganic and Medicinal Chemistry Letters 60 , 128588. 10.1016/j.bmcl.2022.128588
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Henderson, Scott H., Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Ashall-Kelly, Alexander, Hopkins Navratilova, Iva, Walter, Daryl S., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2021. Discovery and characterization of selective and ligand-efficient DYRK inhibitors. Journal of Medicinal Chemistry 64 (15) , 11709–11728. 10.1021/acs.jmedchem.1c01115
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Zeng, Xuezhen, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Zhou, Jingying and Cheng, Alfred S. L. 2021. Liver immune microenvironment and metastasis from colorectal cancer-pathogenesis and therapeutic perspectives. Cancers 13 (10) , 2418. 10.3390/cancers13102418
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Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., Goodyear, Richard J., Derudas, Marco, Cantillon, Daire M., Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N., Osgood, Richard T., Wilson, Charlotte Donald, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2021. Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI Insight 6 (7) , e145704. 10.1172/jci.insight.145704
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Cockerill, G. Stuart, Angell, Richard M., Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A., Good, James A. D., Harland, Rachel, Johnson, Sara M., Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S., Paradowski, Michael, Peeples, Mark E., Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Watterson, Daniel, Williams, Gareth, Young, Paul and Powell, Kenneth 2021. Discovery of sisunatovir (RV521), an inhibitor of respiratory syncytial virus fusion. Journal of Medicinal Chemistry 64 (7) , pp. 3658-3676. 10.1021/acs.jmedchem.0c01882
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Chen, Xiangrong, Ali, Yusuf I., Fisher, Charlotte E. L., Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B., Williams, Gareth, Walker, Sarah, Booth, Jessica R., Hudson, Jessica J. R., Roe, S. Mark, Pearl, Laurence H., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Pearl, Frances M. G. and Oliver, Antony W. 2021. Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife 10 , e65339. 10.7554/eLife.65339
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Henderson, Scott H, Sorrell, Fiona, Bennett, James, Hanley, Marcus T, Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan M and Ward, Simon E ORCID: https://orcid.org/0000-0002-8745-8377 2020. Mining public domain data to develop selective DYRK1A inhibitors. ACS Medicinal Chemistry Letters 11 , pp. 1620-1626. 10.1021/acsmedchemlett.0c00279
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Milton-Harris, Leanne, Jeeves, Mark, Walker, Sarah A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Mancini, Erika J. 2020. Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2. Oncotarget 11 (19) , pp. 1737-1748. 10.18632/oncotarget.27580
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Scott, Fiona, Fala, Angela M., Pennicott, Lewis E., Reuillon, Tristan D., Massirer, Katlin B., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2020. Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer. Bioorganic and Medicinal Chemistry Letters 30 (8) , 127040. 10.1016/j.bmcl.2020.127040
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Maramai, Samuele, Benchekroun, Mohamed, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X 2020. Subtype selective y-Aminobutyric acid type A receptor (GABAAR) modulators acting at the benzodiazepine binding site: An update. Journal of Medicinal Chemistry 63 (7) , pp. 3425-3446. 10.1021/acs.jmedchem.9b01312
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Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark H., Aldegheri, Laura, Bradford, Andrea M., Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X and Woolley, Marie 2020. Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile. Journal of Psychopharmacology 34 (1) , pp. 93-102. 10.1177/0269881119872198
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O'Reilly, Molly, Kirkwood, Nerissa K., Kenyon, Emma J., Huckvale, Rosemary, Cantillon, Daire M., Waddell, Simon J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Richardson, Guy P., Kros, Corné J. and Derudas, Marco 2019. Design, synthesis, and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry 62 (11) , pp. 5312-5329. 10.1021/acs.jmedchem.8b01325
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Mok, M.T. S, Zhou, J, Tang, W, Zeng, X, Oliver, A, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Cheng, A. S.L 2018. CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharmacology & Therapeutics 186 , pp. 138-151. 10.1016/j.pharmthera.2018.01.008

Henderson, Scott H., West, Ryan A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Honey, Mark A. 2018. Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science 5 (6) , 180333. 10.1098/rsos.180333
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West, Ryan A., Cunningham, Thomas, Pennicott, Lewis E., Rao, Srinivasa P. S. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2018. Toward more drug like inhibitors of trypanosome alternative oxidase. ACS Infectious Diseases 4 (4) , pp. 592-604. 10.1021/acsinfecdis.7b00218
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Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., O'reilly, Molly, Derudas, Marco, Cantillon, Daire M., Goodyear, Richard J., Secker, Abigail, Baxendale, Sarah, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2017. Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI Insight 2 (24) , e96773. 10.1172/jci.insight.96773
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West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John ORCID: https://orcid.org/0000-0002-3410-791X, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2017. African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry 141 , pp. 676-689. 10.1016/j.ejmech.2017.09.067
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Kirkwood, Nerissa K., O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J., Huckvale, Rosemary, van Netten, Sietse M., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Richardson, Guy P. and Kros, Corné J. 2017. d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience 11 , 262. 10.3389/fncel.2017.00262
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Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Beswick, Paul, Calcinaghi, Novella, Dawson, Lee A., Gartlon, Jane, Graziani, Francesca, Jones, Declan N. C., Lacroix, Laurent, Mok, M. H. Selina, Oliosi, Beatrice, Pardoe, Joanne, Starr, Kathryn, Woolley, Marie L. and Harries, Mark H. 2017. Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. British Journal of Pharmacology 174 (5) , pp. 370-385. 10.1111/bph.13696
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Meisenberg, Cornelia, Ashour, Mohamed E., El-Shafie, Lamia, Liao, Chunyan, Hodgson, Adam, Pilborough, Alice, Khurram, Syed A., Downs, Jessica A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and El-Khamisy, Sherif F. 2017. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Research 45 (3) , pp. 1159-1176. 10.1093/nar/gkw1026
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Phuangsawai, Oraphan, Beswick, Paul, Ratanabunyong, Siriluk, Tabtimmai, Lueacha, Suphakun, Praphasri, Obounchoey, Phongphat, Srisook, Pimonwan, Horata, Natharinee, Chuckowree, Irina, Hannongbua, Supa, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Choowongkomon, Kiattawee and Gleeson, M. Paul 2016. Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors. European Journal of Medicinal Chemistry 124 , pp. 896-905. 10.1016/j.ejmech.2016.08.055
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Ocasio, Cory A., Rajasekaran, Mohan B., Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M.G., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Savic, Velibor, Pearl, Laurence H., Hochegger, Helfrid and Oliver, Antony W. 2016. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget 7 (44) , pp. 71182-71197. 10.18632/oncotarget.11511
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Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X, Pearl, Laurence H., Caldecott, Keith W. and Oliver, Antony W. 2016. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal 473 (13) , pp. 1869-1879. 10.1042/BCJ20160180
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Re:Viral Ltd 2016. Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV). WO2016055780A1. [Patent].

Moore, Thomas O., Paradowski, Michael and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2016. An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation. Organic and Biomolecular Chemistry 14 (12) , pp. 3307-3313. 10.1039/C6OB00340K
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Janssen Pharmaceuticals, Inc. 2016. Pyrazoles as NMDA NR2B receptor inhibitors and their preparation. WO2016025918A1. [Patent].

Janssen Pharmaceuticals, Inc. 2016. Triazoles as nr2b receptor inhibitors. WO2016025917A1. [Patent].

Reuillon, Tristan, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Beswick, Paul 2016. AMPA receptor positive allosteric modulators: Potential for the treatment of neuropsychiatric and neurological disorders. Current Topics in Medicinal Chemistry 16 (29) , pp. 3536-3565. 10.2174/1568026616666160627114507
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Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Dawson, L. A., Konneh, M. and MacDonald, G. 2016. Alzheimer's disease therapeutics - Are we making progress towards a disease-modifying treatment for patients? Highlights from the Society for Medicines Research Symposium, held June 20, 2016. Presented at: Society for Medicines Research Symposium, 20th June 2016. Drugs of the Future. , vol.41 (7) Prous Science, p. 461. 10.1358/dof.2016.041.07.2516439

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Pennicott, Lewis E and Beswick, Paul 2015. AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Medicinal Chemistry 7 (4) , pp. 473-491. 10.4155/fmc.15.4

Pearl, Laurence H., Schierz, Amanda C., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Al-Lazikani, Bissan and Pearl, Frances M. G. 2015. Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer 15 (3) , pp. 166-180. 10.1038/nrc3891

Brown, K.A., Davenport, R. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2015. Effective and emerging strategies for utilizing structure in drug discovery. Presented at: Society for Medicines Research Meeting, 19th March 2015. Drugs of the Future. , vol.40 (4) Prous Science, pp. 251-256. 10.1358/dof.2015.040.04.2314768

Meisenberg, C., Gilbert, D. C., Chalmers, A., Haley, V., Gollins, S., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and El-Khamisy, S. F. 2014. Clinical and cellular Roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Molecular Cancer Therapeutics 14 (2) , pp. 575-585. 10.1158/1535-7163.MCT-14-0762

Meisenberg, Cornelia, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Schmid, Peter and El-Khamisy, Sherif F 2014. TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. Journal of Cancer Science & Therapy 06 (07) , pp. 258-267. 10.4172/1948-5956.1000280
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Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Beswick, Paul 2014. What does the aromatic ring number mean for drug design? Expert Opinion on Drug Discovery 9 (9) , pp. 995-1003. 10.1517/17460441.2014.932346

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A., Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H., Pearl, Laurence H., Oliver, Antony W., El-Khamisy, Sherif, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X 2014. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry 454 , pp. 17-22. 10.1016/j.ab.2014.03.004
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University of Sussex 2013. Neurodevelopmental disorders. WO 2013/038200 A2. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2013. Targets and emerging therapies for schizophrenia. Edited by Jeffrey S. Albert and Michael W. Wood [Book Review]. ChemMedChem 8 (3) , p. 529. 10.1002/cmdc.201200589

Convergence Pharmaceutical Ltd 2012. Piperazine derivatives as cav2.2 calcium channel blockers. WO2012098400A1. [Patent].

Convergence Pharmaceuticals Ltd 2012. Tetrazole compounds as calcium channel blockers. WO2012004604A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Austin, Nigel E., Ballantine, Stuart, Ballini, Elisa, Bradley, Daniel M., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Clarke, Brian P., Harris, Andrew J., Harrison, Stephen A., Melarange, Rosemary A., Mookherjee, Claudette, Mosley, Julie, Dal Negro, Gianni, Oliosi, Beatrice, Smith, Kathrine J., Thewlis, Kevin M., Woollard, Patrick M. and Yusaf, Shahnaz P. 2011. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. Journal of Medicinal Chemistry 54 (1) , pp. 78-94. 10.1021/jm100679e

Davenport, R., Armour, R. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2011. Trends in pain research. Presented at: The Society for Medicines Research Pain Meeting, Girton College, Cambridge, UK, 24 March 2011. Drugs of the Future. , vol.36 (12) Prous Science, pp. 943-948. 10.1358/dof.2011.036.12.1738058

Cowley, P., Hales, N. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2011. Trends in medicinal chemistry. Presented at: The Society For Medicines Resarch Symposiun, NHLI, London, UK, 9 December 2010. Drugs of the Future. , vol.36 (7) Prous Science, pp. 543-549. 10.1358/dof.2011.036.07.1622065

Leslie, Colin P., Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M., Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J., Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A., Stasi, Luigi P., Tibasco, Jessica, Vong, Antonio, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Zonzini, Laura 2010. Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a potent, selective, and orally active 5-HT1A/B/DReceptor antagonist. Journal of Medicinal Chemistry 53 (23) , pp. 8228-8240. 10.1021/jm100714c

Thewlis, Kevin M., Aldegheri, Laura, Harries, Mark H., Mookherjee, Claudette, Oliosi, Beatrice and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2010. N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorganic & Medicinal Chemistry Letters 20 (23) , pp. 7116-7119. 10.1016/j.bmcl.2010.09.062

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Andreotti, Daniele, Ballantine, Stuart, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Harris, Andrew J., Harker, Andy J., Lund, Jesper, Melarange, Rosemary, Mingardi, Anna, Mookherjee, Claudette, Mosley, Julie, Neve, Marta, Oliosi, Beatrice, Profeta, Roberto, Smith, Kathrine J., Smith, Paul W., Spada, Simone, Thewlis, Kevin M. and Yusaf, Shahnaz P. 2010. Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. Journal of Medicinal Chemistry 53 (15) , pp. 5801-5812. 10.1021/jm1005429

Glaxo Group Limited 2010. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2010066658A1. [Patent].

Glaxo Group Limited 2010. N- inden- 2 -yl- isopropylsulfonamides as ampa receptor potentiators. WO2010057865A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Harries, Mark 2010. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology 160 (2) , pp. 181-190. 10.1111/j.1476-5381.2010.00726.x

Glaxo Group Limited 2010. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2010037760. [Patent].

Glaxo Group Limited 2010. Pyrazolo [1, 5-a] pyrimidine derivatives. WO2010007074A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Watson, Jeannette M. 2010. Recent advances in the discovery of selective and non-selective 5-HT1D receptor ligands. Current Topics in Medicinal Chemistry 10 (5) , pp. 479-492. 10.2174/156802610791111533

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Harries, Mark 2010. Recent advances in the discovery of selective AMPA receptor positive allosteric modulators. Current Medicinal Chemistry 17 (30) , pp. 3503-3513. 10.2174/092986710792927840

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009092712A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009092713A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009080637A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2009053448A1. [Patent].

Glaxo Group Limited 2009. Thiazoles which potentiate ampa receptor and medicinal uses thereof. WO2009053449A1. [Patent].

Alderton, W., Karran, E. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2009. Current and future perspectives in psychiatric drug discovery. Presented at: Society for Medicines Research Symposium, GlaxoSmithKline, Harlow, U.K, 12 March 2009. Drug News & Perspectives. , vol.22 (6) Thomson Reuters, pp. 360-364. 10.1358/dnp.2009.22.6.1380328

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M. and Wyman, Paul A. 2008. Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Biorganic and Medicinal Chemistry Letters 19 (2) , pp. 428-432. 10.1016/j.bmcl.2008.11.052

Glaxo Group Limited 2008. Compounds which potentiate AMPA receptor and uses thereof in medicine. WO2008113795. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2008110566A1. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses therof in medicine. WO2008148832A1. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2008053031A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Eddershaw, Peter J., Scott, Claire M., Gordon, Laurie J., Lovell, Peter J., Moore, Susan H., Smith, Paul W., Starr, Kathryn R., Thewlis, Kevin M. and Watson, Jeannette M. 2008. Discovery of potent, orally bioavailable, selective 5-HT1A/B/DReceptor antagonists. Journal of Medicinal Chemistry 51 (10) , pp. 2887-2890. 10.1021/jm8001444

Gillespie, Roger J., Adams, David R., Bebbington, David, Benwell, Karen, Cliffe, Ian A., Dawson, Claire E., Dourish, Colin T., Fletcher, Allan, Gaur, Suneel, Giles, Paul R., Jordan, Allan M., Knight, Antony R., Knutsen, Lars J.S., Lawrence, Anthony, Lerpiniere, Joanne, Misra, Anil, Porter, Richard H.P., Pratt, Robert M., Shepherd, Robin, Upton, Rebecca, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Weiss, Scott M. and Williamson, Douglas S. 2008. Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Biorganic and Medicinal Chemistry Letters 18 (9) , pp. 2916-2919. 10.1016/j.bmcl.2008.03.075

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Glaxo Group Limited 2007. 4-phenyl-3-(2-propylsulfonylamino) tetrahydrofuran derivatives which potentiate glutamate receptors and are useful in the treatment of schizophrenia. WO2007090840A1. [Patent].

Glaxo Group Limited 2007. Compounds which potentiate glutamate receptor and uses thereof in medicine. WO2007090841A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Johnson, Christopher N., Lovell, Peter J., Scott, Claire M., Smith, Paul W., Stemp, Geoffrey, Thewlis, Kevin M., Vong, Antonio K. and Watson, Jeannette M. 2007. Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands. Biorganic and Medicinal Chemistry Letters 17 (18) , pp. 5214-5217. 10.1016/j.bmcl.2007.06.078

Ahmad, Nadia M., Rodeschini, Vincent, Simpkins, Nigel S., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Blake, Alexander J. 2007. Synthesis of polyprenylated acylphloroglucinols using bridgehead lithiation: the total synthesis of racemic clusianone and a formal synthesis of racemic garsubellin A. The Journal of Organic Chemistry 72 (13) , pp. 4803-4815. 10.1021/jo070388h

Ahmad, Nadia M., Rodeschini, Vincent, Simpkins, Nigel S., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Wilson, Claire 2007. Synthetic studies towards garsubellin A: synthesis of model systems and potential mimics by regioselective lithiation of bicyclo[3.3.1]nonane-2,4,9-trione derivatives from catechinic acid. Organic & Biomolecular Chemistry 5 (12) , pp. 1924-1934. 10.1039/b704311b

Craig, Donald, Hyland, Christopher J. T. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2006. Stereoselective synthesis of (-)-trachelanthamidine (IV) via palladium-catalyzed intramolecular allylation. Chem Inform 37 (50) 10.1002/chin.200650213

Lovell, Peter J., Blaney, Frank E., Goodacre, Caroline J., Scott, Claire M., Smith, Paul W., Starr, Kathryn R., Thewlis, Kevin M., Vong, Antonio K.K., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Watson, Jeannette M. 2006. 3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors. Bioorganic and Medicinal Chemistry Letters 17 (4) , pp. 1033-1036. 10.1016/j.bmcl.2006.11.031

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Glaxo Group Limited 2006. Glycine transport inhibitors. WO2006067423A1. [Patent].

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Glaxo Group Limited 2006. Compounds which potentiate glutamate receptor and uses thereof in medicine. WO2006015829. [Patent].

Craig, Donald, Hyland, Christopher J. T. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2005. Stereoselective γ-lactam synthesis via palladium-catalysed intramolecular allylation. Chemical Communications- Royal Society of Chemistry (27) , pp. 3439-3441. 10.1039/b504731e

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harrington, Frank P., Gordon, Laurie J., Hopley, Susanna C., Scott, Claire M. and Watson, Jeannette M. 2005. Discovery of the first potent, selective 5-Hydroxytryptamine1D receptor antagonist [Letter]. Journal of Medicinal Chemistry 48 (10) , pp. 3478-3480. 10.1021/jm049039v

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Glaxo Group Limited 2003. Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors. WO2003068771A1. [Patent].

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Vernalis Research Limited 2000. 2-adamantanemethanamine compounds for treating abnormalities in glutamatergic transmission. WO2000044371A1. [Patent].

Vernalis Research Limited 2000. 4-quinolinemethanol derivatives as purine receptor antagonists (i). WO2000013681A2. [Patent].

Cerebrus Pharmaceuticals Limited 1999. 1-(adamantyl)amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission. WO1999031051A1. [Patent].

Adger, Brian M., Dyer, Ulrich C., Lennon, Ian C., Tiffin, Peter D. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 1998. A novel synthesis of tert-leucine via a Leuckart type reaction. Tetrahedron Letters 38 (12) , pp. 2153-2154. 10.1016/S0040-4039(97)00269-4

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Holmes, Andrew B. and McCague, Ray 1997. Total synthesis of carbocyclic nikkomycin C. Chemical Communications- Royal Society of Chemistry (21) , pp. 2085-2086. 10.1039/a705825j

Congreve, Miles S., Davison, Edwin C., Fuhry, Mary Ann M., Holmes, Andrew B., Payne, Andrew N., Robinson, R. Anthony and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 1993. Selective cleavage of benzyl ethers [Letter]. Synlett 1993 (09) , pp. 663-664. 10.1055/s-1993-22563

Davis, A. M. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 The handbook of medicinal chemistry principles and practice. Cambridge: Royal Society of Chemistry.

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 AMPA receptor positive allosteric modulators a case history. Cox, B. and Gosling, M., eds. Ion Channel Drug Discovery, Vol. 39. RSC Drug Discovery Series, vol. 39. Cambridge: Royal Society of Chemistry, pp. 105-134.

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 DNA damage repair pathways and synthetic lethality. Lackey, K. and Roth, B., eds. Medicinal Chemistry Approaches to Personalized Medicine, Vol. 59. Wiley-Blackwell, pp. 183-210.

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 Neurotransmitters and other non-opiate central mechanisms. Allerton, C., ed. Pain Therapeutics: Current and Future Paradigms, RSC Drug Discovery Series, vol. 35. Cambridge: Royal Society of Chemistry, pp. 171-196.

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 Discovery and clinical data for a novel AMPA receptor positive modulator. Rankovic, Z., Hargreaves, R. and Bingham, M., eds. Drug Discovery for Psychiatric Disorders, RSC Drug Discovery Series, vol. 28. Cambridge: Royal Society of Chemistry, pp. 99-122. (10.1039/9781849734943)

This list was generated on Thu May 30 06:21:14 2024 BST.