Browse by Current Cardiff authors

Cubitt, Jonathan, Davies, Mari, Riseley, Ross, Evans, Gabrielle, Gardiner, Sian E., Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Lloyd-Evans, Emyr ORCID: https://orcid.org/0000-0002-3626-1611, Waller-Evans, Helen ORCID: https://orcid.org/0000-0003-4133-6064 and Jones, D. Heulyn 2024. Beware of N-Benzoyloxybenzamides. Molecules 29 (21) , 5143. 10.3390/molecules29215143

Morgan, Harry, Nicholls, Robert A., Warren, Anna J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Evans, Gwyndaf, Long, Fei, Murshudov, Garib N., Duman, Ramona and Bax, Benjamin D. 2024. How do Gepotidacin and Zoliflodacin stabilize DNA cleavage complexes with bacterial Type IIA topoisomerases? 1. Experimental definition of metal binding sites. International Journal of Molecular Sciences 25 (21) , 11688. 10.3390/ijms252111688

Henderson, Scott, Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus, Godoi, Paulo, de Sousa, Roberta Ruela, Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2024. Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases. European Journal of Medicinal Chemistry 269 , 16292. 10.1016/j.ejmech.2024.116292

Zhou, Jingying, Wang, Huanyu, Shu, Ting, Wang, Jing, Yang, Weiqin, Li, Jingqing, Ding, Lipeng, Liu, Man, Sun, Hanyong, Wong, John, Lai, Paul Bo-san, Tsang, Shun-Wa, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Chow, King-Lau, Sung, Joseph Jao-yiu and Sze-Lok Cheng, Alfred 2023. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience 26 (10) , 107626. 10.1016/j.isci.2023.107626

Derudas, Marco, O’Reilly, Molly, Kirkwood, Nerissa K., Kenyon, Emma J., Grimsey, Sybil, Kitcher, Siân R., Workman, Shawna, Bull, James C., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2023. Charge and lipophilicity are required for effective block of the hair-cell mechano-electrical transducer channel by FM1-43 and its derivatives. Frontiers in Cell and Developmental Biology 11 , 1247324. 10.3389/fcell.2023.1247324

Thomas, Bedwyr, Lewis, Lois, Jones, Dyfyr and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2023. Central nervous system targeted protein degraders. Biomolecules 13 (8) , 1164. 10.3390/biom13081164

Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Davis, Andrew M. 2023. Lead optimisation: what you should know! Ward, Simon E. and Davis, Andrew, eds. The Handbook of Medicinal Chemistry: Principles and Practice, The Royal Society of Chemistry, pp. 720-768. (10.1039/9781788018982-00720)

University College Cardiff Consultants Limited 2022. Heteroaryl compounds useful in the treatment of cognitive disorders. WO2022/234271. [Patent].

Collins, Ross, Lee, Hyunah, Jones, Dyfyr, Elkins, Jonathan M., Gillespie, Jason A., Thomas, Carys, Baldwin, Alex G. ORCID: https://orcid.org/0000-0002-7126-5220, Jones, Kimberley, Waters, Loren, Paine, Marie, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Grubisha, Olivera ORCID: https://orcid.org/0000-0003-1067-1230 and Foley, David W. ORCID: https://orcid.org/0000-0001-8449-4754 2022. Comparative analysis of small-molecule limk1/2 inhibitors: chemical synthesis, biochemistry, and cellular activity. Journal of Medicinal Chemistry 10.1021/acs.jmedchem.2c00751

Koulouris, Chloe R., Gardiner, Sian E., Harris, Tessa K., Elvers, Karen T., Mark Roe, S., Gillespie, Jason A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Grubisha, Olivera ORCID: https://orcid.org/0000-0003-1067-1230, Nicholls, Robert A., Atack, John R. and Bax, Benjamin D. 2022. Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase. Communications Biology 5 (1) , 346. 10.1038/s42003-022-03264-5

Scott, Fiona, Fala, Angela M., Takarada, Jessica E., Ficu, Mihaela P., Pennicott, Lewis E., Reuillon, Tristan D., Couñago, Rafael M., Massirer, Katlin B., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2022. Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery. Bioorganic and Medicinal Chemistry Letters 60 , 128588. 10.1016/j.bmcl.2022.128588

Henderson, Scott H., Sorrell, Fiona, Bennett, James, Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Ashall-Kelly, Alexander, Hopkins Navratilova, Iva, Walter, Daryl S., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2021. Discovery and characterization of selective and ligand-efficient DYRK inhibitors. Journal of Medicinal Chemistry 64 (15) , 11709–11728. 10.1021/acs.jmedchem.1c01115

Zeng, Xuezhen, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Zhou, Jingying and Cheng, Alfred S. L. 2021. Liver immune microenvironment and metastasis from colorectal cancer-pathogenesis and therapeutic perspectives. Cancers 13 (10) , 2418. 10.3390/cancers13102418

Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., Goodyear, Richard J., Derudas, Marco, Cantillon, Daire M., Baxendale, Sarah, de la Vega de León, Antonio, Mahieu, Virginia N., Osgood, Richard T., Wilson, Charlotte Donald, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2021. Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity. JCI Insight 6 (7) , e145704. 10.1172/jci.insight.145704

Cockerill, G. Stuart, Angell, Richard M., Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A., Good, James A. D., Harland, Rachel, Johnson, Sara M., Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S., Paradowski, Michael, Peeples, Mark E., Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Watterson, Daniel, Williams, Gareth, Young, Paul and Powell, Kenneth 2021. Discovery of sisunatovir (RV521), an inhibitor of respiratory syncytial virus fusion. Journal of Medicinal Chemistry 64 (7) , pp. 3658-3676. 10.1021/acs.jmedchem.0c01882

Chen, Xiangrong, Ali, Yusuf I., Fisher, Charlotte E. L., Arribas-Bosacoma, Raquel, Rajasekaran, Mohan B., Williams, Gareth, Walker, Sarah, Booth, Jessica R., Hudson, Jessica J. R., Roe, S. Mark, Pearl, Laurence H., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Pearl, Frances M. G. and Oliver, Antony W. 2021. Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein. eLife 10 , e65339. 10.7554/eLife.65339

Henderson, Scott H, Sorrell, Fiona, Bennett, James, Hanley, Marcus T, Robinson, Sean, Hopkins Navratilova, Iva, Elkins, Jonathan M and Ward, Simon E ORCID: https://orcid.org/0000-0002-8745-8377 2020. Mining public domain data to develop selective DYRK1A inhibitors. ACS Medicinal Chemistry Letters 11 , pp. 1620-1626. 10.1021/acsmedchemlett.0c00279

Milton-Harris, Leanne, Jeeves, Mark, Walker, Sarah A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Mancini, Erika J. 2020. Small molecule inhibits T-cell acute lymphoblastic leukaemia oncogenic interaction through conformational modulation of LMO2. Oncotarget 11 (19) , pp. 1737-1748. 10.18632/oncotarget.27580

Scott, Fiona, Fala, Angela M., Pennicott, Lewis E., Reuillon, Tristan D., Massirer, Katlin B., Elkins, Jonathan M. and Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 2020. Development of 2-(4-pyridyl)-benzimidazoles as PKN2 chemical tools to probe cancer. Bioorganic and Medicinal Chemistry Letters 30 (8) , 127040. 10.1016/j.bmcl.2020.127040

Maramai, Samuele, Benchekroun, Mohamed, Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X 2020. Subtype selective y-Aminobutyric acid type A receptor (GABAAR) modulators acting at the benzodiazepine binding site: An update. Journal of Medicinal Chemistry 63 (7) , pp. 3425-3446. 10.1021/acs.jmedchem.9b01312

Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark H., Aldegheri, Laura, Bradford, Andrea M., Ballini, Elisa, Dawson, Lee, Lacroix, Laurent, Pardoe, Joanne, Starr, Kathryn, Weil, Annette, Waters, Kerry, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X and Woolley, Marie 2020. Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile. Journal of Psychopharmacology 34 (1) , pp. 93-102. 10.1177/0269881119872198

O'Reilly, Molly, Kirkwood, Nerissa K., Kenyon, Emma J., Huckvale, Rosemary, Cantillon, Daire M., Waddell, Simon J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Richardson, Guy P., Kros, Corné J. and Derudas, Marco 2019. Design, synthesis, and biological evaluation of a new series of carvedilol derivatives that protect sensory hair cells from aminoglycoside-induced damage by blocking the mechanoelectrical transducer channel. Journal of Medicinal Chemistry 62 (11) , pp. 5312-5329. 10.1021/acs.jmedchem.8b01325

Mok, M.T. S, Zhou, J, Tang, W, Zeng, X, Oliver, A, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Cheng, A. S.L 2018. CCRK is a novel signalling hub exploitable in cancer immunotherapy. Pharmacology & Therapeutics 186 , pp. 138-151. 10.1016/j.pharmthera.2018.01.008

Henderson, Scott H., West, Ryan A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Honey, Mark A. 2018. Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science 5 (6) , 180333. 10.1098/rsos.180333

West, Ryan A., Cunningham, Thomas, Pennicott, Lewis E., Rao, Srinivasa P. S. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2018. Toward more drug like inhibitors of trypanosome alternative oxidase. ACS Infectious Diseases 4 (4) , pp. 592-604. 10.1021/acsinfecdis.7b00218

Kenyon, Emma J., Kirkwood, Nerissa K., Kitcher, Siân R., O'reilly, Molly, Derudas, Marco, Cantillon, Daire M., Goodyear, Richard J., Secker, Abigail, Baxendale, Sarah, Bull, James C., Waddell, Simon J., Whitfield, Tanya T., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Kros, Corné J. and Richardson, Guy P. 2017. Identification of ion-channel modulators that protect against aminoglycoside-induced hair cell death. JCI Insight 2 (24) , e96773. 10.1172/jci.insight.96773

West, Ryan A., O'Doherty, Oran G., Askwith, Trevor, Atack, John ORCID: https://orcid.org/0000-0002-3410-791X, Beswick, Paul, Laverick, Jamie, Paradowski, Michael, Pennicott, Lewis E., Rao, Srinivasa P.S., Williams, Gareth and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2017. African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European Journal of Medicinal Chemistry 141 , pp. 676-689. 10.1016/j.ejmech.2017.09.067

Kirkwood, Nerissa K., O'Reilly, Molly, Derudas, Marco, Kenyon, Emma J., Huckvale, Rosemary, van Netten, Sietse M., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Richardson, Guy P. and Kros, Corné J. 2017. d-Tubocurarine and berbamine: alkaloids that are permeant blockers of the hair cell's mechano-electrical transducer channel and protect from aminoglycoside toxicity. Frontiers in Cellular Neuroscience 11 , 262. 10.3389/fncel.2017.00262

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Beswick, Paul, Calcinaghi, Novella, Dawson, Lee A., Gartlon, Jane, Graziani, Francesca, Jones, Declan N. C., Lacroix, Laurent, Mok, M. H. Selina, Oliosi, Beatrice, Pardoe, Joanne, Starr, Kathryn, Woolley, Marie L. and Harries, Mark H. 2017. Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. British Journal of Pharmacology 174 (5) , pp. 370-385. 10.1111/bph.13696

Meisenberg, Cornelia, Ashour, Mohamed E., El-Shafie, Lamia, Liao, Chunyan, Hodgson, Adam, Pilborough, Alice, Khurram, Syed A., Downs, Jessica A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and El-Khamisy, Sherif F. 2017. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Research 45 (3) , pp. 1159-1176. 10.1093/nar/gkw1026

Phuangsawai, Oraphan, Beswick, Paul, Ratanabunyong, Siriluk, Tabtimmai, Lueacha, Suphakun, Praphasri, Obounchoey, Phongphat, Srisook, Pimonwan, Horata, Natharinee, Chuckowree, Irina, Hannongbua, Supa, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Choowongkomon, Kiattawee and Gleeson, M. Paul 2016. Evaluation of the anti-malarial activity and cytotoxicity of 2,4-diamino-pyrimidine-based kinase inhibitors. European Journal of Medicinal Chemistry 124 , pp. 896-905. 10.1016/j.ejmech.2016.08.055

Ocasio, Cory A., Rajasekaran, Mohan B., Walker, Sarah, Le Grand, Darren, Spencer, John, Pearl, Frances M.G., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Savic, Velibor, Pearl, Laurence H., Hochegger, Helfrid and Oliver, Antony W. 2016. A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget 7 (44) , pp. 71182-71197. 10.18632/oncotarget.11511

Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377, Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X, Pearl, Laurence H., Caldecott, Keith W. and Oliver, Antony W. 2016. Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2. Biochemical Journal 473 (13) , pp. 1869-1879. 10.1042/BCJ20160180

Re:Viral Ltd 2016. Spiro-indolines for the treatment and prophylaxis of respiratory syncytial virus infection (RSV). WO2016055780A1. [Patent].

Moore, Thomas O., Paradowski, Michael and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2016. An atom-efficient and convergent approach to the preparation of NS5A inhibitors by C-H activation. Organic and Biomolecular Chemistry 14 (12) , pp. 3307-3313. 10.1039/C6OB00340K

Janssen Pharmaceuticals, Inc. 2016. Pyrazoles as NMDA NR2B receptor inhibitors and their preparation. WO2016025918A1. [Patent].

Janssen Pharmaceuticals, Inc. 2016. Triazoles as nr2b receptor inhibitors. WO2016025917A1. [Patent].

Reuillon, Tristan, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Beswick, Paul 2016. AMPA receptor positive allosteric modulators: Potential for the treatment of neuropsychiatric and neurological disorders. Current Topics in Medicinal Chemistry 16 (29) , pp. 3536-3565. 10.2174/1568026616666160627114507

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Dawson, L. A., Konneh, M. and MacDonald, G. 2016. Alzheimer's disease therapeutics - Are we making progress towards a disease-modifying treatment for patients? Highlights from the Society for Medicines Research Symposium, held June 20, 2016. Presented at: Society for Medicines Research Symposium, 20th June 2016. Drugs of the Future. , vol.41 (7) Prous Science, p. 461. 10.1358/dof.2016.041.07.2516439

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Pennicott, Lewis E and Beswick, Paul 2015. AMPA receptor-positive allosteric modulators for the treatment of schizophrenia: an overview of recent patent applications. Future Medicinal Chemistry 7 (4) , pp. 473-491. 10.4155/fmc.15.4

Pearl, Laurence H., Schierz, Amanda C., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Al-Lazikani, Bissan and Pearl, Frances M. G. 2015. Therapeutic opportunities within the DNA damage response. Nature Reviews Cancer 15 (3) , pp. 166-180. 10.1038/nrc3891

Brown, K.A., Davenport, R. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2015. Effective and emerging strategies for utilizing structure in drug discovery. Presented at: Society for Medicines Research Meeting, 19th March 2015. Drugs of the Future. , vol.40 (4) Prous Science, pp. 251-256. 10.1358/dof.2015.040.04.2314768

Meisenberg, C., Gilbert, D. C., Chalmers, A., Haley, V., Gollins, S., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and El-Khamisy, S. F. 2014. Clinical and cellular Roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan. Molecular Cancer Therapeutics 14 (2) , pp. 575-585. 10.1158/1535-7163.MCT-14-0762

Meisenberg, Cornelia, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Schmid, Peter and El-Khamisy, Sherif F 2014. TDP1/TOP1 Ratio as a Promising Indicator for the Response of Small Cell Lung Cancer to Topotecan. Journal of Cancer Science & Therapy 06 (07) , pp. 258-267. 10.4172/1948-5956.1000280

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Beswick, Paul 2014. What does the aromatic ring number mean for drug design? Expert Opinion on Drug Discovery 9 (9) , pp. 995-1003. 10.1517/17460441.2014.932346

Walker, Sarah, Meisenberg, Cornelia, Bibby, Rachel A., Askwith, Trevor, Williams, Gareth, Rininsland, Frauke H., Pearl, Laurence H., Oliver, Antony W., El-Khamisy, Sherif, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Atack, John R. ORCID: https://orcid.org/0000-0002-3410-791X 2014. Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors. Analytical Biochemistry 454 , pp. 17-22. 10.1016/j.ab.2014.03.004

University of Sussex 2013. Neurodevelopmental disorders. WO 2013/038200 A2. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2013. Targets and emerging therapies for schizophrenia. Edited by Jeffrey S. Albert and Michael W. Wood [Book Review]. ChemMedChem 8 (3) , p. 529. 10.1002/cmdc.201200589

Convergence Pharmaceutical Ltd 2012. Piperazine derivatives as cav2.2 calcium channel blockers. WO2012098400A1. [Patent].

Convergence Pharmaceuticals Ltd 2012. Tetrazole compounds as calcium channel blockers. WO2012004604A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Austin, Nigel E., Ballantine, Stuart, Ballini, Elisa, Bradley, Daniel M., Bax, Benjamin ORCID: https://orcid.org/0000-0003-1940-3785, Clarke, Brian P., Harris, Andrew J., Harrison, Stephen A., Melarange, Rosemary A., Mookherjee, Claudette, Mosley, Julie, Dal Negro, Gianni, Oliosi, Beatrice, Smith, Kathrine J., Thewlis, Kevin M., Woollard, Patrick M. and Yusaf, Shahnaz P. 2011. Integration of lead optimization with crystallography for a membrane-bound ion channel target: discovery of a new class of AMPA receptor positive allosteric modulators. Journal of Medicinal Chemistry 54 (1) , pp. 78-94. 10.1021/jm100679e

Davenport, R., Armour, R. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2011. Trends in pain research. Presented at: The Society for Medicines Research Pain Meeting, Girton College, Cambridge, UK, 24 March 2011. Drugs of the Future. , vol.36 (12) Prous Science, pp. 943-948. 10.1358/dof.2011.036.12.1738058

Cowley, P., Hales, N. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2011. Trends in medicinal chemistry. Presented at: The Society For Medicines Resarch Symposiun, NHLI, London, UK, 9 December 2010. Drugs of the Future. , vol.36 (7) Prous Science, pp. 543-549. 10.1358/dof.2011.036.07.1622065

Leslie, Colin P., Biagetti, Matteo, Bison, Silvia, Bromidge, Steven M., Di Fabio, Romano, Donati, Daniele, Falchi, Alessandro, Garnier, Martine J., Jaxa-Chamiec, Albert, Manchee, Gary, Merlo, Giancarlo, Pizzi, Domenica A., Stasi, Luigi P., Tibasco, Jessica, Vong, Antonio, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Zonzini, Laura 2010. Discovery of 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (GSK163090), a potent, selective, and orally active 5-HT1A/B/DReceptor antagonist. Journal of Medicinal Chemistry 53 (23) , pp. 8228-8240. 10.1021/jm100714c

Thewlis, Kevin M., Aldegheri, Laura, Harries, Mark H., Mookherjee, Claudette, Oliosi, Beatrice and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2010. N-Substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. Bioorganic & Medicinal Chemistry Letters 20 (23) , pp. 7116-7119. 10.1016/j.bmcl.2010.09.062

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Harries, Mark, Aldegheri, Laura, Andreotti, Daniele, Ballantine, Stuart, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785, Harris, Andrew J., Harker, Andy J., Lund, Jesper, Melarange, Rosemary, Mingardi, Anna, Mookherjee, Claudette, Mosley, Julie, Neve, Marta, Oliosi, Beatrice, Profeta, Roberto, Smith, Kathrine J., Smith, Paul W., Spada, Simone, Thewlis, Kevin M. and Yusaf, Shahnaz P. 2010. Discovery of N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. Journal of Medicinal Chemistry 53 (15) , pp. 5801-5812. 10.1021/jm1005429

Glaxo Group Limited 2010. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2010066658A1. [Patent].

Glaxo Group Limited 2010. N- inden- 2 -yl- isopropylsulfonamides as ampa receptor potentiators. WO2010057865A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Bax, Benjamin D. ORCID: https://orcid.org/0000-0003-1940-3785 and Harries, Mark 2010. Challenges for and current status of research into positive modulators of AMPA receptors. British Journal of Pharmacology 160 (2) , pp. 181-190. 10.1111/j.1476-5381.2010.00726.x

Glaxo Group Limited 2010. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2010037760. [Patent].

Glaxo Group Limited 2010. Pyrazolo [1, 5-a] pyrimidine derivatives. WO2010007074A1. [Patent].

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Watson, Jeannette M. 2010. Recent advances in the discovery of selective and non-selective 5-HT1D receptor ligands. Current Topics in Medicinal Chemistry 10 (5) , pp. 479-492. 10.2174/156802610791111533

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Harries, Mark 2010. Recent advances in the discovery of selective AMPA receptor positive allosteric modulators. Current Medicinal Chemistry 17 (30) , pp. 3503-3513. 10.2174/092986710792927840

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009092712A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009092713A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate the ampa receptor and uses thereof in medicine. WO2009080637A1. [Patent].

Glaxo Group Limited 2009. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2009053448A1. [Patent].

Glaxo Group Limited 2009. Thiazoles which potentiate ampa receptor and medicinal uses thereof. WO2009053449A1. [Patent].

Alderton, W., Karran, E. and Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 2009. Current and future perspectives in psychiatric drug discovery. Presented at: Society for Medicines Research Symposium, GlaxoSmithKline, Harlow, U.K, 12 March 2009. Drug News & Perspectives. , vol.22 (6) Thomson Reuters, pp. 360-364. 10.1358/dnp.2009.22.6.1380328

Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Eddershaw, Peter, Flynn, Sean T., Gordon, Laurie, Lovell, Peter J., Moore, Susan H., Scott, Claire M., Smith, Paul W., Thewlis, Kevin M. and Wyman, Paul A. 2008. Studies on a series of potent, orally bioavailable, 5-HT1 receptor ligands-Part II. Biorganic and Medicinal Chemistry Letters 19 (2) , pp. 428-432. 10.1016/j.bmcl.2008.11.052

Glaxo Group Limited 2008. Compounds which potentiate AMPA receptor and uses thereof in medicine. WO2008113795. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2008110566A1. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses therof in medicine. WO2008148832A1. [Patent].

Glaxo Group Limited 2008. Compounds which potentiate ampa receptor and uses thereof in medicine. WO2008053031A1. [Patent].

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Gillespie, Roger J., Adams, David R., Bebbington, David, Benwell, Karen, Cliffe, Ian A., Dawson, Claire E., Dourish, Colin T., Fletcher, Allan, Gaur, Suneel, Giles, Paul R., Jordan, Allan M., Knight, Antony R., Knutsen, Lars J.S., Lawrence, Anthony, Lerpiniere, Joanne, Misra, Anil, Porter, Richard H.P., Pratt, Robert M., Shepherd, Robin, Upton, Rebecca, Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377, Weiss, Scott M. and Williamson, Douglas S. 2008. Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives. Biorganic and Medicinal Chemistry Letters 18 (9) , pp. 2916-2919. 10.1016/j.bmcl.2008.03.075

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Ahmad, Nadia M., Rodeschini, Vincent, Simpkins, Nigel S., Ward, Simon ORCID: https://orcid.org/0000-0002-8745-8377 and Blake, Alexander J. 2007. Synthesis of polyprenylated acylphloroglucinols using bridgehead lithiation: the total synthesis of racemic clusianone and a formal synthesis of racemic garsubellin A. The Journal of Organic Chemistry 72 (13) , pp. 4803-4815. 10.1021/jo070388h

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