Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae

Yang, Qiu E, Agouri, Siham Rajab, Tyrrell, Jonathan Mark ORCID: https://orcid.org/0000-0001-8565-2590 and Walsh, Timothy Rutland ORCID: https://orcid.org/0000-0003-4315-4096 2018. Heavy metal resistance genes are associated with blaNDM-1 and blaCTX-M-15-Enterobacteriaceae. Antimicrobial Agents and Chemotherapy 62 (5) , e02642-17. 10.1128/AAC.02642-17

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Abstract

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing blaNDM-1 or blaCTX-M-15 genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in blaNDM-1-positive (48.8% to 71.8%) and blaCTX-M-15-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Society for Microbiology
ISSN:	0066-4804
Date of First Compliant Deposit:	22 March 2018
Date of Acceptance:	5 March 2018
Last Modified:	16 Nov 2024 05:45
URI:	https://orca.cardiff.ac.uk/id/eprint/110104

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