Newland, B.  ORCID: https://orcid.org/0000-0002-5214-2604, Taplan, C., Pette, D., Friedrichs, J., Steinhart, M., Wang, W., Voit, B., Seib, F. P. and Werner, C.
2018.
Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery.
Nanoscale
10
(18)
, pp. 8413-8421.
10.1039/C8NR00603B
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Abstract
Nanotubes are emerging as promising materials for healthcare applications but the selection of clinically relevant starting materials for their synthesis remains largely unexplored. Here we present, for the first time, the synthesis of poly(ethylene glycol) (PEG) based nanotubes via the photopolymerization of poly(ethylene glycol) diacrylate and other diacrylate derivatives within the pores of anodized aluminum oxide templates. Template-assisted synthesis allowed the manufacture of a diverse set of polymeric nanotubes with tunable physical characteristics including diameter (∼200–400 nm) and stiffness (405–902 kPa). PEG nanotubes were subjected to cytotoxicty assessment in cell lines and primary stem cells and showed excellent cytocompatability (IC50 > 120 μg ml−1). Nanotubes were readily drug loaded but released the majority of the drug over 5 days. Direct administration of drug loaded nanotubes to human orthotopic breast tumors substantially reduced tumor growth and metastasis and outperformed i.v. administration at the equivalent dose. Overall, this nanotube templating platform is emerging as a facile route for the manufacture of poly(ethylene glycol) nanotubes.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Pharmacy Cardiff University Brain Research Imaging Centre (CUBRIC) |
| Additional Information: | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 2040-3364 |
| Date of First Compliant Deposit: | 3 May 2018 |
| Date of Acceptance: | 27 March 2018 |
| Last Modified: | 05 May 2023 11:00 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/111177 |
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