Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions

Henderson, Scott H., West, Ryan A., Ward, Simon E. ORCID: https://orcid.org/0000-0002-8745-8377 and Honey, Mark A. 2018. Metal-free selective mono-halodecarboxylation of heteroarenes under mild conditions. Royal Society Open Science 5 (6) , 180333. 10.1098/rsos.180333

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Abstract

The halodecarboxylation of heteroarene carboxylic acids by treatment with N-bromosuccinimide or N-chlorosuccinimide was performed. This procedure provides a convenient route to synthetically useful mono-halogenated heteroarene intermediates such as halo-indoles, -aza-indoles, -indazoles and -aza-indazoles. The mild conditions employed and simple protocol provides an advantage over traditional halodecarboxylation procedures that require expensive and toxic metal catalysts, basic conditions, time-consuming intermediate isolation and elevated reaction temperatures.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Royal Society, The
ISSN:	2054-5703
Date of First Compliant Deposit:	20 June 2018
Date of Acceptance:	10 April 2018
Last Modified:	05 May 2023 07:54
URI:	https://orca.cardiff.ac.uk/id/eprint/112611

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