Interleukin 6: the biology behind the therapy

Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Takeuchi, Tsutomu, Aletaha, Daniel, Smolen, Josef, Choy, Ernest H ORCID: https://orcid.org/0000-0003-4459-8609 and McInnes, Iain 2019. Interleukin 6: the biology behind the therapy. Considerations in Medicine 2 10.1136/conmed-2018-000005

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Abstract

The cytokine interleukin (IL)−6 performs a diverse portfolio of functions in normal physiology and disease. These functions extend beyond the typical role for an inflammatory cytokine, and IL-6 often displays hormonelike properties that affect metabolic processes associated with lipid metabolism, insulin resistance, and the neuroendocrine system. Consequently, the biology of IL-6 is complex. Recent advances in the field have led to novel interpretations of how IL-6 delivers immune homeostasis in health and yet drives disease pathology during infection, autoimmunity, and cancer. Various biological drugs that target IL-6 are in clinical practice or emerging in clinical trials and pre-clinical development programmes. The challenge is knowing how and when to apply these therapies. In this review, we will explore the biology behind IL-6 directed therapies and identify some key hurdles for future investigation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	BMJ Publishing Group
ISSN:	2515-3919
Date of First Compliant Deposit:	26 June 2018
Date of Acceptance:	31 May 2018
Last Modified:	22 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/112756

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