Browse by Current Cardiff authors

Rose‐John, Stefan and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2025. More and more pleiotropy within the IL ‐6 family of cytokines. The FEBS Journal 292 (3) , pp. 519-522. 10.1111/febs.17355

Odd, David ORCID: https://orcid.org/0000-0002-6416-4966, Sabir, Hemmen, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Gale, Chris and Chakkarapani, Ela 2024. Risk factors for infection and outcomes in infants with neonatal encephalopathy: a cohort study. Pediatric Research 96 , pp. 785-791. 10.1038/s41390-024-03157-9

Millrine, David, Cardus Figueras, Ana, Uceda Fernandez, Javier, Andrews, Robert, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Cossins, Benjamin, Rice, Christopher M., Li, Jasmine, Tyrrell, Victoria, McLeod, Louise, Holmans, Peter ORCID: https://orcid.org/0000-0003-0870-9412, O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460, Taylor, Philip ORCID: https://orcid.org/0000-0003-0163-1421, Turner, Stephen J., Jenkins, Brendan J., Jones, Gareth, Topley, Nicholas, Williams, Nigel ORCID: https://orcid.org/0000-0003-1177-6931 and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2023. Th1 cells alter the inflammatory signature of IL-6 by channeling STAT transcription factors to Alu-like retroelements. The Journal of Immunology 211 (2) , pp. 274-286. 10.4049/jimmunol.2300114

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L, Marsden, Morgan, Chapman, Lucy, Cardus Figueras, Anna, Scott, Jake, Andrews, Robert, Clare, Simon, Kriukova, Valeriia V, Lupyr, Ksenia R, Britanova, Olga V, Withers, David R, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Chudakov, Dmitriy M, Price, David A ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R ORCID: https://orcid.org/0000-0002-9512-5337 2023. Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1. eLife 12 , e79165. 10.7554/eLife.79165

Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Rice, Christopher M., Fernandez, Javier U. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2023. Tracking the host response to infection in peritoneal models of acute resolving inflammation. Jenkins, B.J., ed. Inflammation and Cancer, Vol. 2691. Methods in Molecular Biology, New York: Springer, pp. 81-95. (10.1007/978-1-0716-3331-1_7)

Karhunen, Ville, Gill, Dipender, Huang, Jian, Bouras, Emmanouil, Malik, Rainer, Ponsford, Mark J, Ahola-Olli, Ari, Papadopoulou, Areti, Palaniswamy, Saranya, Sebert, Sylvain, Wielscher, Matthias, Auvinen, Juha, Veijola, Juha, Herzig, Karl-Heinz, Timonen, Markku, Keinänen-Kiukaanniemi, Sirkka, Dichgans, Martin, Salmi, Marko, Jalkanen, Sirpa, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli, Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Hovingh, G Kees, Tsilidis, Konstantinos K, Järvelin, Marjo-Riitta and Dehghan, Abbas 2023. The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study. BMJ Medicine 2 (1) , e000157. 10.1136/bmjmed-2022-000157

Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Jenkins, Robert H ORCID: https://orcid.org/0000-0001-8500-9044, Hughes, Stuart T O and Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711 2022. Making sense of IL-6 signalling cues in pathophysiology. FEBS Letters 596 (5) , pp. 567-588. 10.1002/1873-3468.14201

Misheva, Mariya, Kotzamanis, Konstantinos, Davies, Luke C., Tyrrell, Victoria J., Rodrigues, Patricia R. S. ORCID: https://orcid.org/0000-0003-0768-0013, Benavides, Gloria A., Hinz, Christine, Murphy, Robert C., Kennedy, Paul, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Deshpande, Sumukh, Andrews, Robert, Schebb, Nils Helge, Czubala, Magdalena A. ORCID: https://orcid.org/0000-0001-9881-1095, Gurney, Mark ORCID: https://orcid.org/0000-0003-1119-6638, Aldrovandi, Maceler, Meckelmann, Sven W., Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Darley-Usmar, Victor, White, Daniel A. and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13 (1) , 139. 10.1038/s41467-021-27766-8

Jenkins, Robert H. ORCID: https://orcid.org/0000-0001-8500-9044, Hughes, Stuart T.O., Cardus Figueras, Ana and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2021. Unravelling the broader complexity of IL-6 involvement in health and disease. Cytokine 148 , 155684. 10.1016/j.cyto.2021.155684

Heise, Denise, Derrac Soria, Alicia, Hansen, Selina, Dambietz, Christine, Akbarzadeh, Mohammad, Berg, Anna F., Waetzig, Georg H., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Dvorsky, Radovan, Ahmadian, Mohammad R., Scheller, Jürgen and Moll, Jens M. 2021. Selective inhibition of IL-6 trans-signaling by a miniaturized, optimized chimeric soluble gp130 inhibits TH17 cell expansion. Science Signaling 14 (696) , eabc3480. 10.1126/scisignal.abc3480

Davies, Ruth, Williams, Jessica, Sime, Katie, Jin, Hyun-Sun, Thompson, Charlotte, Jordan, Lauren, Lang, Derek, Halcox, Julian P, Ellins, Elizabeth ORCID: https://orcid.org/0000-0001-5164-6416, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2021. The role of interleukin-6 trans-signalling on cardiovascular dysfunction in inflammatory arthritis. Rheumatology 60 (6) , pp. 2852-2861. 10.1093/rheumatology/keaa725

Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Hunter, Christopher A. 2021. Is IL-6 a key cytokine target for therapy in COVID-19? Nature Reviews Immunology 21 (6) , 337–339. 10.1038/s41577-021-00553-8

Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Bryant, Clare, Lloyd, Clare M, McInnes, Iain and O'Neill, Luke 2020. A vision for cytokine biology with 20/20 clarity. Function 2 (1) , zqaa042. 10.1093/function/zqaa042

Ponsford, Mark J., Gkatzionis, Apostolos, Walker, Venexia M., Grant, Andrew J., Wootton, Robyn E., Moore, Luke S.P., Fatumo, Segun, Mason, Amy M., Zuber, Verena, Willer, Cristen, Rasheed, Humaira, Brumpton, Ben, Hveem, Kristian, Kristian Damås, Jan, Davies, Neil, Olav Åsvold, Bjørn, Solligård, Erik, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Burgess, Stephen, Rogne, Tormod and Gill, Dipender 2020. Cardiometabolic traits, sepsis, and severe COVID-19. Circulation 142 (18) , 1791–1793. 10.1161/CIRCULATIONAHA.120.050753

Lucchesi, Davide, Coleby, Rachel, Pontarini, Elena, Prediletto, Edoardo, Rivellese, Felice, Hill, David G., Derrac Soria, Alicia, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Sutcliffe, Nurhan, Tappuni, Anwar R., Pitzalis, Costantino, Jones, Gareth W. ORCID: https://orcid.org/0000-0001-7297-9711 and Bombardieri, Michele 2020. Impaired IL‐27 mediated control of CD4+ T cell function impacts on ectopic lymphoid structure formation in patients with Sjögren's Syndrome. Arthritis and Rheumatology 72 (9) , pp. 1559-1570. 10.1002/art.41289

Harbour, Stacey N., DiToro, Daniel F., Witte, Steven J., Zindl, Carlene L., Gao, Min, Schoeb, Trenton R., Jones, Gareth W., Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Hatton, Robin D. and Weaver, Casey T. 2020. Th17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Science Immunology 5 (49) , eaaw2262. 10.1126/sciimmunol.aaw2262

O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Thomas, David ORCID: https://orcid.org/0000-0001-7319-5820, Stanton, Richard ORCID: https://orcid.org/0000-0002-6799-1182, Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Murphy, Robert C., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337, Wakelam, Michael J. O., Fegan, Christopher ORCID: https://orcid.org/0000-0001-9685-0621, Wise, Matt P., Bosch, Albert and Sattar, Syed A. 2020. Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection. Function 1 (1) , zqaa002. 10.1093/function/zqaa002

Jones, Hannah J. ORCID: https://orcid.org/0000-0001-7297-9711, Hubbard, Leon, Mitchell, Ruth E., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Zammit, Stanley ORCID: https://orcid.org/0000-0002-2647-9211 and Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009 2019. Association of genetic risk for rheumatoid arthritis with cognitive and psychiatric phenotypes across childhood and adolescence. JAMA Network Open 2 (6) , -. 10.1001/jamanetworkopen.2019.6118

Twohig, Jason P., Cardus Figueras, Ana, Andrews, Robert, Wiede, Florian, Cossins, Benjamin C., Derrac Soria, Alicia, Lewis, Myles J., Townsend, Michael J., Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151, Li, Jasmine, Hill, David G., Uceda Fernandez, Javier, Liu, Xiao, Szomolay, Barbara ORCID: https://orcid.org/0000-0002-5375-5533, Pepper, Christopher J., Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Pitzalis, Costantino, Tiganis, Tony, Williams, Nigel M. ORCID: https://orcid.org/0000-0003-1177-6931, Jones, Gareth W. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2019. Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells. Nature Immunology 20 , pp. 458-470. 10.1038/s41590-019-0350-0

Jones, Simon A ORCID: https://orcid.org/0000-0001-7297-9711, Takeuchi, Tsutomu, Aletaha, Daniel, Smolen, Josef, Choy, Ernest H ORCID: https://orcid.org/0000-0003-4459-8609 and McInnes, Iain 2019. Interleukin 6: the biology behind the therapy. Considerations in Medicine 2 10.1136/conmed-2018-000005

Takeuchi, Tsutomu, Smolen, Josef S., Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Aletaha, Daniel, McInnes, Iain and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2019. Considering new lessons about the use of IL-6 inhibitors in arthritis. BMJ Considerations in Medicine 2 (1) , pp. 7-11. 10.1136/conmed-2018-000002

Smolen, Josef S., Aletaha, Daniel, Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Takeuchi, Tsutomu and McInnes, Iain 2019. Targeting IL-6: a review of data. BMJ Considerations in Medicine 2 (1) , pp. 12-18. 10.1136/conmed-2018-000003

Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Aletaha, Daniel, Takeuchi, Tsutomu, McInnes, Iain and Smolen, Josef S 2019. IL-6: To immunity and beyond. BMJ Considerations in Medicine 2 (1) , pp. 19-23. 10.1136/conmed-2018-000004

Rivellese, Felice, Mauro, Daniele, Nerviani, Alessandra, Pagani, Sara, Fossati-Jimack, Liliane, Messemaker, Tobias, Kurreeman, Fina, Toes, Rene, Rauber, Simon, Schett, Georg, Jones, Gareth, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Rossi, Francesca, de Paulis, Amato, Marone, Gianni, El Shikh, Mohey Eldin and Humby, Frances 2018. Mast cells in early rheumatoid arthritis associate with disease severity and support B-cell autoantibody production. Annals of the Rheumatic Diseases 77 (12) , pp. 1773-1781. 10.1136/annrheumdis-2018-213418

Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Jenkins, Brendan J. 2018. Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer. Nature Reviews Immunology 18 , pp. 773-789. 10.1038/s41577-018-0066-7

Jones, Gareth, Hill, David, Cardus Figueras, Ana and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2018. IL-27 - a double agent in the IL-6 family. Clinical and Experimental Immunology 193 (1) , pp. 37-46. 10.1111/cei.13116

Fernandez, Javier Uceda, Millrine, David ORCID: https://orcid.org/0000-0002-8041-0151 and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2018. Tracking competent host defence to chronic inflammation: An In Vivo model of peritonitis. Jenkins, Brendan J., ed. Inflammation and Cancer, Vol. 1725. Methods in Molecular Biology, New York, NY: Springer, pp. 65-75. (10.1007/978-1-4939-7568-6_6)

Lauder, Sarah N., Allen-Redpath, Keith, Slatter, David A., Aldrovandi, Maceler, O'Connor, Anne, Farewell, Daniel ORCID: https://orcid.org/0000-0002-8871-1653, Percy, Charles L., Molhoek, Jessica E., Rannikko, Sirpa, Tyrrell, Victoria J., Ferla, Salvatore ORCID: https://orcid.org/0000-0002-5918-9237, Milne, Ginger L., Poole, Alastair W., Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Obaji, Samya, Taylor, Philip R., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, deGroot, Philip G., Urbanus, Rolf T., Horkko, Sohvi, Uderhardt, Stefan, Ackermann, Jochen, Jenkins, P. Vince, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Kronke, Gerhard, Collins, Peter W. ORCID: https://orcid.org/0000-0002-6410-1324 and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2017. Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis. Science Signaling 10 (507) , eaan2787. 10.1126/scisignal.aan2787

Stacey, Maria A., Clare, Simon, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Abdul-Karim, Juneid, Kane, Leanne, Harcourt, Katherine, Brandt, Cordelia, Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Smith, Sarah E., Wash, Rachael S., Gimeno Brias, Silvia, Stack, Gabrielle, Notley, George, Cambridge, Emma L., Isherwood, Christopher, Speak, Anneliese O., Johnson, Zoe, Ferlin, Walter, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Kellam, Paul and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2017. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. Journal of Clinical Investigation 127 (4) , pp. 1463-1474. 10.1172/JCI84889

Catar, Rusan, Witowski, Janusz, Zhu, Nan, Lücht, Christian, Derrac Soria, Alicia, Uceda Fernandez, Javier, Chen, Lei, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Fielding, Ceri A., Rudolf, Andras, Topley, Nicholas, Dragun, Duska and Jörres, Achim 2017. IL-6 trans-signaling links inflammation with angiogenesis in the peritoneal membrane. Journal of the American Society of Nephrology 28 (4) , pp. 1188-1199. 10.1681/ASN.2015101169

Dutzan, Nicolas, Abusleme, Loreto, Bridgeman, Hayley, Greenwell-Wild, Teresa, Zangerle-Murray, Tamsin, Fife, Mark E., Bouladoux, Nicolas, Linley, Holly, Brenchley, Laura, Wemys, Kelly, Calderon, Gloria, Hong, Bo-Young, Break, Timothy J., Bowdish, Dawn M. E., Lionakis, Michail S., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Trinchieri, Giorgio, Diaz, Patricia I., Belkaid, Yasmine and Konkel, Joanne E. 2017. On-going mechanical damage from mastication drives homeostatic Th17 cell responses at the oral barrier. Immunity 46 (1) , pp. 133-147. 10.1016/j.immuni.2016.12.010

Lauder, Sarah N., Tyrrell, Victoria J., Allen-Redpath, Keith, Aldrovandi, MacEler, Gray, David, Collins, Peter ORCID: https://orcid.org/0000-0002-6410-1324, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 and O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460 2017. Myeloid 12/15-LOX regulates B cell numbers and innate immune antibody levels in vivo. Wellcome Open Research 2 (1) 10.12688/wellcomeopenres.10308.1

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Stacey, Maria, Abdul-Karim, Juneid, Gimeno Brias, Silvia, Costa Bento, Diana Filipa, Scurr, Martin ORCID: https://orcid.org/0000-0002-4120-0688, Weaver, Casey, Carlesso, Gianluca, Clare, Simon, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Godkin, Andrew ORCID: https://orcid.org/0000-0002-1910-7567, Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Jones, Gareth W. and Humphreys, Ian ORCID: https://orcid.org/0000-0002-9512-5337 2016. Cytomegalovirus-specific IL-10-producing CD4+ T cells are governed by type-I IFN-induced IL-27 and promote virus persistence. Plos Pathogens 12 (12) , e1006050. 10.1371/journal.ppat.1006050

Jones, Gareth, Hill, David and Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711 2016. Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together. Frontiers in Immunology 7 , pp. 1-13. 10.3389/fimmu.2016.00401

Liao, Chia-Te, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke C., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Tyrrell, Victoria J., O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Topley, Nicholas, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 2016. IL-10 differentially controls the infiltration of inflammatory macrophages and antigen-presenting cells during inflammation. European Journal of Immunology 46 (9) , pp. 2222-2232. 10.1002/eji.201646528

Davies, Ruth, Iacono, Daniela, Jordan, Lauren, Williams, Jessica O., Sime, Katie, Rawlings, Charlotte, Lang, Derek, Jones, Simon ORCID: https://orcid.org/0000-0001-7297-9711, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2016. Serum Vascular Cell Adhesion Molecule 1 levels are associated with vascular Dysfunction and increased cardiovascular risk in an animal model and patients with Rheumatoid Arthritis. Rheumatology 55 (Supp 1) , p. 54. 10.1093/rheumatology/kew102.004

Harvey, Ann K, Lelos, Mariah Jillian ORCID: https://orcid.org/0000-0001-7102-055X, Greenhill, Claire J., Jones, Ashley, Clinch, Susanne, Newton, Michael, Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Wyatt, Sean Lee ORCID: https://orcid.org/0000-0002-0572-234X, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2016. Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis. Journal of Rheumatic Diseases and Treatment 2 (2) , 033. 10.23937/2469-5726/1510033

Liu, Xiang, Jones, Gareth W., Choy, Ernest H. ORCID: https://orcid.org/0000-0003-4459-8609 and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2016. The biology behind interleukin-6 targeted interventions. Current Opinion in Rheumatology 28 (2) , pp. 152-160. 10.1097/BOR.0000000000000255

Jones, Gareth Wyn and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2016. Ectopic lymphoid follicles: inducible centres for generating antigen-specific immune responses within tissues. Immunology 147 (2) , pp. 141-151. 10.1111/imm.12554

Lacroix, Marine, Rousseau, François, Guilhot, Florence, Malinge, Pauline, Magistrelli, Giovanni, Herren, Suzanne, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Scheller, Jürgen, Lissilaa, Rami, Kosco-Vilbois, Marie, Johnson, Zoë, Buatois, Vanessa and Ferlin, Walter 2015. Novel insights into IL-6 cis- and trans-signaling pathways by differentially manipulating the assembly of the IL-6 signaling complex. Journal of Biological Chemistry 290 , pp. 26943-26953. 10.1074/jbc.M115.682138

Jones, Gareth W., Bombardieri, Michele, Greenhill, Claire J., McLeod, Louise, Nerviani, Alessandra, Rocher-Ros, Vidalba, Cardus, Anna, Williams, Anwen S. ORCID: https://orcid.org/0000-0001-6118-020X, Pitzalis, Costantino, Jenkins, Brendan J. and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2015. Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis. Journal of Experimental Medicine 212 (11) , pp. 1793-1802. 10.1084/jem.20132307

Beyer, Christian, Huang, Jingang, Beer, Jürgen, Zhang, Yun, Palumbo-Zerr, Katrin, Zerr, Pawel, Distler, Alfiya, Dees, Clara, Maier, Christiane, Munoz, Louis, Krönke, Gerhard, Uderhardt, Stefan, Distler, Oliver, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan, Oravecz, Tamas, Schett, Georg and Distler, Jörg HW 2015. Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages. Annals of the Rheumatic Diseases 74 (6) , pp. 1317-1324. 10.1136/annrheumdis-2013-204401

Hunter, Christopher A. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2015. IL-6 as a keystone cytokine in health and disease. Nature Immunology 16 (5) , pp. 448-457. 10.1038/ni.3153

Rosser, Elizabeth C., Oleinika, Kristine, Tonon, Silvia, Doyle, Ronan, Bosma, Anneleen, Carter, Natalie A., Harris, Kathryn A., Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, Klein, Nigel and Mauri, Claudia 2014. Regulatory B cells are induced by gut microbiota- driven interleukin-1β and interleukin-6 production. Nature Medicine 20 , pp. 1334-1339. 10.1038/nm.3680

Garbers, Christoph, Monhasery, Niloufar, Aparicio-Siegmund, Samadhi, Lokau, Juliane, Baran, Paul, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, Jürgen 2014. The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases. Biochimica et Biophysica Acta - Molecular Basis of Disease 1842 (9) , pp. 1485-1494. 10.1016/j.bbadis.2014.05.018

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Newton, Zarabeth, Harvey, Ann K., Moideen, Abdul Nazeer, Collins, Fraser L., Bloom, Anja C., Coll, Rebecca C., Robertson, Avril A. B., Cooper, Matthew A., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, Luke A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2014. Interleukin-10 regulates the inflammasome-driven augmentation of inflammatory arthritis and joint destruction. Arthritis Research and Therapy 16 (4) , 419. 10.1186/s13075-014-0419-y

Pitzalis, Costantino, Jones, Gareth Wyn, Bombardieri, Michele and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2014. Ectopic lymphoid-like structures in infection, cancer and autoimmunity. Nature Reviews Immunology 14 (7) , pp. 447-462. 10.1038/nri3700

Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke C., Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C. ORCID: https://orcid.org/0000-0003-4591-9611, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421 2014. The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal. Science 344 (6184) , pp. 645-648. 10.1126/science.1251414

Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Jones, Gareth Wyn 2014. Interleukin-6 in renal disease and therapy. Nephrology Dialysis Transplantation 30 (4) , pp. 564-574. 10.1093/ndt/gfu233

Fielding, Ceri A. ORCID: https://orcid.org/0000-0002-5817-3153, Jones, Gareth W. ORCID: https://orcid.org/0000-0001-7297-9711, McLoughlin, Rachel M., McLeod, Louise, Hammond, Victoria J., Uceda, Javier, Williams, Anwen S. ORCID: https://orcid.org/0000-0003-3768-9940, Lambie, Mark, Foster, Thomas L., Liao, Chia-Te, Rice, Christopher M., Greenhill, Claire J., Colmont, Chantal S., Hams, Emily ORCID: https://orcid.org/0000-0002-9745-3246, Coles, Barbara, Kift-Morgan, Ann, Newton, Zarabeth, Craig, Katherine J., Williams, John D. ORCID: https://orcid.org/0000-0003-3768-9940, Williams, Geraint T. ORCID: https://orcid.org/0000-0003-3768-9940, Davies, Simon J., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Jenkins, Brendan J., Topley, Nicholas and Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711 2014. Interleukin-6 signaling drives fibrosis in unresolved inflammation. Immunity 40 (1) , pp. 40-50. 10.1016/j.immuni.2013.10.022

Lauder, Sarah Nicol, Jones, Emma, Smart, Kathryn, Bloom, Anja Constanze, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hindley, James P., Ondondo, Beatrice, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2013. Interleukin-6 limits influenza-induced inflammation and protects against fatal lung pathology. European Journal of Immunology 43 (10) , pp. 2613-2625. 10.1002/eji.201243018

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Harvey, Ann, Moideen, Abdul Nazeer, Collins, Fraser, Bloom, Anja Constanze, Coll, R., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, O'Neill, L. A., Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2013. Interleukin 10 control of the inflammasome restricts arthritic bone erosion [Abstract]. Cytokine 63 (3) , p. 267. 10.1016/j.cyto.2013.06.105

Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Jones, Gareth Wyn, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jenkins, Brendan J., Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2013. IL-6 regulation of Th1 responses drives fibrosis in unresolved inflammation [Abstract]. Cytokine 63 (3) , p. 262. 10.1016/j.cyto.2013.06.082

Davies, Luke Cynlais, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin John ORCID: https://orcid.org/0000-0002-4120-0688, Brombacher, Frank, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Allen, Judith E., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2013. Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation. Nature Communications 4 , 1886. 10.1038/ncomms2877

Orr, Selinda Jane, Burg, Ashley R., Chan, Tim, Quigley, Laura, Jones, Gareth Wyn, Ford, Jill W., Hodge, Deborah, Razzook, Catherine, Sarhan, Joseph, Jones, Yava L., Whittaker, Gillian C., Boelte, Kimberly C., Lyakh, Lyudmila, Cardone, Marco, O'Connor, Geraldine M., Tan, Cuiyan, Li, Hongchuan, Anderson, Stephen K., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Zhang, Weiguo, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Trinchieri, Giorgio and McVicar, Daniel W. 2013. LAB/NTAL facilitates fungal/PAMP-induced IL-12 and IFN-γ production by repressing β-catenin activation in dendritic cells. PLoS Pathogens 9 (5) , e1003357. 10.1371/journal.ppat.1003357

Moideen, Abdul Nazeer, Evans, Laura, Osgood, Louise Emma, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 and Nowell, Mari Ann 2013. Characterization of enzymes involved in nicotinamide adenine dinucleotide biosynthesis in rheumatoid arthritis synovium and cytokine-stimulated synovial fibroblasts [Abstracts]. Rhuematology 52 (s1) , pp. 138-139.

Choy, Ernest Ho Sing ORCID: https://orcid.org/0000-0003-4459-8609, Kavanaugh, A. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2013. The problem of choice: current biologic agents and future prospects in RA [review]. Nature Reviews Rheumatology 9 (3) , pp. 154-163. 10.1038/nrrheum.2013.8

Chakraborty, Mallinath, McGreal, Eamon Patrick, Davies, Philip Lloyd, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2013. Role of interleukin-6, its receptor and soluble gp130 in chronic lung disease of prematurity. Neonatology 104 (3) , pp. 161-167. 10.1159/000351015

McDonald, Jacqueline U., Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Brown, Gordon D., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2012. Differential dependencies of monocytes and neutrophils on dectin-1, dectin-2 and complement for the recognition of fungal particles in inflammation. PLoS ONE 7 (9) , e45781. 10.1371/journal.pone.0045781

Greenhill, Claire J., Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. Cross-talk between IL-10 and the inflammasome regulates bone erosions during rheumatoid arthritis [Abstract]. Immunology 137 , pp. 43-44.

O'Connor, Richard A., Floess, Stefan, Huehn, Jochen, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Anderton, Stephen M. 2012. Foxp3+Treg cells in the inflamed CNS are insensitive to IL-6-driven IL-17 production. European Journal of Immunology 42 (5) , pp. 1174-1179. 10.1002/eji.201142216

Moideen, Abdul Nazeer, Evans, Laura, Osgood, Louise Emma, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Nowell, Mari Ann 2012. Nicotinamide adenine dinucleotide (NAD plus) biosynthesis enzymes in rheumatoid arthritis [Abstract]. Rhuematology 51 (s3) , p. 142. 10.1093/rheumatology/kes108

Greenhill, Claire, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Nowell, Mari Ann, Moideen, Abdul Nazeer, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. The regulation of arthritic bone erosions by il-10 [Abstract]. Rhuematology 51 , p. 48. 10.1093/rheumatology/kes117

Jones, Gareth Wyn, Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2012. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Rhuematology 51 (s3) , pp. 43-44. 10.1093/rheumatology/kes117

Jones, Gareth Wyn, Greenhill, C. J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, B. J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B-cell responses [Abstract]. Immunology 135 (S1) , p. 158. 10.1111/j.1365-2567.2011.03534.x

Greenhill, Claire J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Nowell, Mari Ann, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. The regulation of arthritic bone erosions by IL-10 [Abstract]. Immunology 135 (s1) , p. 158. 10.1111/j.1365-2567.2011.03534.x

Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Nowell, Mari Ann, Jenkins, Brian J. and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. Interleukin-27 receptor-deficient mice develop exacerbated inflammatory arthritis associated with heightened T- and B- cell responses [Abstract]. Arthritis and Rheumatism 63 (s10) , S978-S978. 10.1002/art.33310

Smale, Shaun, Carty, Sara Madelaine, Goodfellow, Rhian Mair, Choy, Ernest Ho-Sing ORCID: https://orcid.org/0000-0003-4459-8609, Rose-John, Stefan, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Williams, Anwen SIan ORCID: https://orcid.org/0000-0001-6118-020X 2011. Inhibiting IL-6 trans-signalling with soluble gp130Fc potently reduces the incidence and severity of collagen-induced experimental arthritis [Abstract]. Arthritis and Rheumatism 63 (s10) , S446-S447.

Evans, Laura Catherine, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hayes, Anthony Joseph, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Nowell, Mari Ann 2011. Suppression of leukocyte infiltration and cartilage degradation by selective inhibition of pre-B cell colony-enhancing factor/visfatin/nicotinamide phosphoribosyltransferase: Apo866-mediated therapy in human fibroblasts and murine collagen-induced arthritis. Arthritis and Rheumatism 63 (7) , pp. 1866-1877. 10.1002/art.30338

Colmont, Chantal Sophie, Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Dioszeghy, Vincent, Le Bouder, Emmanuel, Foster, Thomas Lloyd, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Topley, Nicholas 2011. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrology Dialysis Transplantation 26 (12) , pp. 4079-4090. 10.1093/ndt/gfr217

McDonald, Jacqueline U., Cortini, Andrea, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Fossati-Jimack, Liliane, Ling, Guang Sheng, Lewis, Kimberley, Dewitt, Sharon ORCID: https://orcid.org/0000-0001-8169-8241, Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Brown, Gordon D., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Hallett, Maurice Bartlett ORCID: https://orcid.org/0000-0001-8197-834X, Botto, Marina and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2011. In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. The FASEB Journal 25 (6) , pp. 1972-1982. 10.1096/fj.10-178517

Lauder, Sarah Nicol, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Clark, Stephen Robert ORCID: https://orcid.org/0000-0001-5907-9671, Evans, Rhys Lloyd, Hindley, James Phillip, Smart, Kathryn, Leach, Heather, Kidd, Emma Jane ORCID: https://orcid.org/0000-0001-5507-1170, Broadley, Kenneth John ORCID: https://orcid.org/0000-0002-3339-2050, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Wise, Matthew Peter, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2011. Paracetamol reduces influenza-induced immunopathology in a mouse model of infection without compromising virus clearance or the generation of protective immunity. Thorax 66 (5) , pp. 368-374. 10.1136/thx.2010.150318

Jones, Gareth Wyn, Stumhofer, Jason S., Foster, Tom, Twohig, Jason Peter, Hertzog, Paul, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Christopher A., Jenkins, Brendan J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2011. Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation. The FASEB Journal 25 (1) , pp. 409-419. 10.1096/fj.10-166843

Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Osario, Fabiola, Robinson, Matthew J., Davies, Luke Cynlais, Dierkes, Nicola, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Reis e Sousa, Caetano and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2011. Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells. European Journal of Immunology 41 (2) , pp. 356-365. 10.1002/eji.201040962

Liddiard, Kate ORCID: https://orcid.org/0000-0002-0953-1997, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Davies, Luke Cynlais, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2011. Macrophage heterogeneity and acute inflammation. European Journal of Immunology 41 (9) , pp. 2503-2508. 10.1002/eji.201141743

Davies, Luke Cynlais, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Smith, Paul James, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 2011. A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation. European Journal of Immunology 41 (8) , pp. 2155-2164. 10.1002/eji.201141817

Kennedy, Catherine L., Najdovska, Meri, Jones, Gareth Wyn, McLeod, Louise, Hughes, Norman R., Allison, Cody, Huey Ooi, Chia, Tan, Patrick, Ferrero, Richard L., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Dev, Anouk, Sievert, William, Bhathal, Prithi S. and Jenkins, Brendan J. 2011. The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. The Journal of Pathology 225 (2) , pp. 255-264. 10.1002/path.2933

Clark, Stephen Robert ORCID: https://orcid.org/0000-0001-5907-9671, Guy, Christopher J., Scurr, Martin J. ORCID: https://orcid.org/0000-0002-4120-0688, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Kift-Morgan, Ann Patricia, Hammond, Victoria Jayne, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Coles, Barbara, Roberts, Gareth Wyn, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas, Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2011. Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection. Blood 117 (6) , pp. 2033-2043. 10.1182/blood-2010-04-278887

Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Scheller, Jürgen and Rose-John, Stefan 2011. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. Journal of Clinical Investigation 121 (9) , pp. 3375-3383. 10.1172/JCI57158

McGreal, Eamon Patrick, Chakraborty, Mallinath, Winter, Vicki T., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Coalson, Jacqueline J. and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2011. Dynamic expression of IL-6 trans-signalling molecules in the lungs of preterm baboons undergoing mechanical ventilation. Neonatology 100 (2) , pp. 130-138. 10.1159/000322148

Stumhofer, Jason S., Tait, Elia D., III, William J. Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, O'Hara, Aisling C., Chen, Yi, Jones, Michael L., Saris, Christiaan J. M., Rose-John, Stefan, Cua, Daniel J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Elloso, Merle M., Grötzinger, Joachim, Cancro, Michael P., Levin, Steven D. and Hunter, Christopher A. 2010. A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nature Immunology 11 (12) , pp. 1119-1126. 10.1038/ni.1957

Jones, Gareth Wyn, Stumhofer, J. S., Foster, T., Twohig, Jason Peter, Hertzog, P., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 2010. Differential responsiveness of naive and activated T cells to TL1A that affect Th17 generation, maintenance and proliferation [Abstract]. Immunology 131 (s1) , p. 102. 10.1111/j.1365-2567.2010.03390.x

Lauder, Sarah Nicol, Smart, Kathryn, Ondondo, B., Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2010. A critical role for interleukin-6 in limiting influenza-induced pathology and generating heterosubtypic immunity [Abstract]. Immunology 131 (S1) , p. 186. 10.1111/j.1365-2567.2010.03390.x

Lissilaa, Rami, Buatois, Vanessa, Magistrelli, Giovanni, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Gareth Wyn, Herren, Suzanne, Shang, Limin, Malinge, Pauline, Guilhot, Florence, Chatel, Laurence, Hatterer, Eric, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Kosco-Vilbois, Marie H. and Ferlin, Walter G. 2010. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. The Journal of Immunology 185 (9) , pp. 5512-5521. 10.4049/jimmunol.1002015

Coles, Barbara, Colmont, Chantal Sophie, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Kift-Morgan, Ann, Hams, Emily, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2010. Local manipulation of IL-6 trans-signaling therapeutically enhances anti-microbial host defense [Abstract]. Cytokine 52 (1-2) , pp. 80-81. 10.1016/j.cyto.2010.07.335

Jones, Gareth Wyn, McLoughlin, Rachel Mary, Hammond, Victoria Jayne, Parker, Clare Rhian, Williams, John, Malhotra, Raj, Scheller, Jurgen, Williams, Anwen ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2010. Loss of CD4+ T Cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. The Journal of Immunology 184 (4) , pp. 2130-2139. 10.4049/jimmunol.0901528

Jones, Gareth Wyn, McLoughlin, R. M., Hammond, Victoria Jayne, Parker, Clare R., Williams, John D., Malhotra, R., Scheller, J., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2010. Loss of CD4(+) T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. Journal of Immunology 184 (4) , pp. 2130-2139.

Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter James, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2010. Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research & Therapy 12 (2) , R49. 10.1186/ar2960

Leggate, Melanie, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Nimmo, Myra N. 2010. The response of interleukin-6 and soluble interleukin-6 receptor isoforms following intermittent high intensity and continuous moderate intensity cycling. Cell Stress and Chaperones 15 (6) , pp. 827-833. 10.1007/s12192-010-0192-z

McGreal, Eamon Patrick, Davies, Philip Lloyd, Powell, Wendy ORCID: https://orcid.org/0000-0002-4670-1406, Rose-John, Stefan, Spiller, Owen Bradley ORCID: https://orcid.org/0000-0002-9117-6911, Doull, Iolo John Manley, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627 2010. Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derived serine proteases in cystic fibrosis. Biochimica et Biophysica Acta - Molecular Basis of Disease 1802 (7-8) , pp. 649-658. 10.1016/j.bbadis.2010.04.005

Page, Charlotte E., Smale, Shaun, Carty, Sara Madelaine, Amos, Nick, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Richards, Peter J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2010. Interferon-gamma inhibits interleukin-1 beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis. Arthritis Research and Therapy 12 (2) , R49.

Cash, Hannes, Relle, Manfred, Menke, Julia, Brochhausen, Christoph, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas, Galle, Peter R. and Schwarting, Andreas 2009. Interleukin 6 (IL-6) deficiency delays lupus nephritis in MRL-faslpr mice: the IL-6 pathway as a new therapeutic target in treatment of autoimmune kidney disease in systemic lupus erythematosus. The Journal of Rheumatology 37 (1) , pp. 60-70. 10.3899/jrheum.090194

Nowell, Mari Ann, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Carty, Sara Madelaine, Scheller, Jurgen, Hayes, Anthony Joseph, Jones, Gareth Wyn, Richards, Peter James, Slinn, Simon James, Ernst, Matthias, Jenkins, Brendan J., Topley, Nicholas, Rose-John, Stephen and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2009. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. Journal of Immunology 182 (1) , pp. 613-622.

Morgan, Alwena Haf, Dioszeghy, Vincent, Maskrey, Benjamin, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Clark, Stephen Robert ORCID: https://orcid.org/0000-0001-5907-9671, Mathie, Sara A., Lloyd, Clare M., Kuhn, Hartmut, Topley, Nicholas, Coles, Barbara, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2009. Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease. Journal of Biological Chemistry 284 (32) , pp. 21185-21191. 10.1074/jbc.M109.021634

Raby, Anne-Catherine ORCID: https://orcid.org/0000-0002-5354-5835, Le Bouder, Emmanuel, Colmont, Chantal Sophie, Davies, James Anthony ORCID: https://orcid.org/0000-0003-3569-4500, Richards, Peter, Coles, Barbara, George, Christopher H., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, Topley, Nicholas and Labeta, Mario Oscar ORCID: https://orcid.org/0000-0001-5750-6983 2009. Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering. The Journal of Immunology 183 (1) , pp. 506-517. 10.4049/jimmunol.0802909

Jones, Gareth Wyn, Stumhofer, J. S., Newton, Zarabeth, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Hunter, Catherine, Jenkins, Brian J., Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2008. TL1A/TNFSF15 promotes a STAT1-mediated suppression of IL-17-secreting T-helper cells [Abstract]. Immunology 125 (s1) , p. 62. 10.1111/j.1365-2567.2008.02974.x

Rabe, B., Chalaris, A., Adams, N., Paliga, K., Lange, H., Laskay, T., Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Waetzig, G. H., Seegert, D., Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Sina, C., Rose-John, Stefan and Schelle, J. 2008. The role of IL6-transsignaling in acute and chronic inflammation [Abstract]. Cytokine 43 (3) , p. 244. 10.1016/j.cyto.2008.07.073

Jenkins, Brendan J., Nadjovska, Meri, Greenhill, Claire, McLeod, Louise, Tye, Hazel, Kennedy, Catherine, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Ernst, Matthias and Hertzog, Paul J. 2008. Differential roles of IL-6 and IL-11 in inflammation and tumorigenesis [Abstract]. Cytokine 43 (3) , p. 243. 10.1016/j.cyto.2008.07.069

Hams, Emily ORCID: https://orcid.org/0000-0002-9745-3246, Colmont, Chantal Sophie, Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2008. Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3) , pp. 2174-2180.

Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, McLoughlin, Rachel Mary, McLeod, Louise, Colmont, Chantal Sophie, Najdovska, Meri, Grail, Dianne, Ernst, Matthias, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Jenkins, Brendan J. 2008. IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. Journal of Immunology 181 (3) , pp. 2189-2195.

Hams, Emily, Colmont, Chantal S., Dioszeghy, Vincent, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2008. Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. Journal of Immunology 181 (3) , pp. 2174-2180.

Morton, Jonathan, Coles, Barbara, Wright, Kate Louise, Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004, Morrow, Jason D., Terry, Erin S., Anning, Peter, Morgan, Bryan Paul ORCID: https://orcid.org/0000-0003-4075-7676, Dioszeghy, Vincent, Kuhn, Hartmut, Chaitidis, Pavlos, Hobbs, Adrian J., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2008. Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN -dependent iNOS expression in the vasculature of healthy mice. Blood 111 (10) , pp. 5187-5194. 10.1182/blood-2007-10-117283

Jones, Gareth Wyn, Newton, Zarabeth, Nowell, Mari Ann, Jenkins, B. J., Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2008. TL1A negatively regulates development of T helper 17 cells [Abstract]. Rheumatology 47 (S2) , II20-II20. 10.1093/rheumatology/kem509

Page, Charlotte E., Smale, Shaun, Lauder, Sarah Nicol, Carty, Sara Madelaine, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Topley, Nicholas and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2008. Ifn gamma protects articular cartilage against IL-1 induced tissue injury in arthritis. C Page, S Smale, S Lauder, S Carty, R Goodfellow, S Jones, N Topley & A Williams. School of medicine, Cardiff University, Cardiff, CF14 4XN [Poster Abstract]. Rhuematology 47 (s2) , II177-II177. 10.1093/rheumatology/kem534

Smale, Shaun, Amos, Nick, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2008. Local activation of STAT3 but not STAT1 during collagen induced arthritis. Correlation with local and systemic cytokine activity [Poster Abstract]. Rheumatology 47 (s2) , II53-II53. 10.1093/rheumatology/kem514

Longhi, Maria Paula, Wright, Kate Louise, Lauder, Sarah Nicol, Nowell, Mari Ann, Jones, Gareth Wyn, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2008. Interleukin-6 is crucial for recall of influenza-specific memory cd4+ t cells. PLoS Pathogens 4 (2) , e1000006. 10.1371/journal.ppat.1000006

Rabe, Bjorn, Chalaris, Athena, May, Ulrike, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, Jurgen 2008. Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood 111 (3) , pp. 1021-1028. 10.1182/blood-2007-07-102137

Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Jones, Gareth Wyn, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Nowell, Mari Ann 2008. Appreciating the balance between classical interleukin (IL)-6 receptor signaling and IL-6 trans-signaling: implications for arthritis progression. Immunology Endocrine & Metabolic Agents in Medicinal Chemistry 8 (3) , pp. 235-246.

Dioszeghy, Vincent, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Maskrey, Benjamin H., Colmont, Chantal Sophie, Topley, Nicholas, Chaitidis, Pavlos, Kühn, Hartmut, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421 and O'Donnell, Valerie Bridget ORCID: https://orcid.org/0000-0003-4089-8460 2008. 12/15-lipoxygenase regulates the inflammatory response to bacterial products in vivo. The Journal of Immunology 181 (9) , pp. 6514-6524.

Rabe, B., Chalaris, Athena, May, Ulrike, Paliga, Krzysztof, Lange, Hans, Laskay, Tamas, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Waetzig, Georg H., Seegert, Dirk, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rose-John, Stefan and Scheller, J. 2007. IL6/sIL6R-transsignaling controls innate and aquired immunity [Abstract]. Cytokine 39 (1) , p. 34. 10.1016/j.cyto.2007.07.129

Jones, Gareth Wyn, Newton, Zarabeth, Jenkins, B. J., Ernst, M., Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2007. TL1A counteracts the IL-6 control of the STAT3-mediated development of T helper 17 cells [Abstract]. Cytokine 39 (1) , pp. 18-19.

Hams, Emily, Dioszechy, Vincent, Colmont, Chantal Sophie, Hammond, Victoria Jayne, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Tanaka, Minoru, Miyajima, Atsushi, Taylor, Philip Russel ORCID: https://orcid.org/0000-0003-0163-1421, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2007. Oncostatin M receptor signalling regulates monocytic cell trafficking during acute inflammation [Abstract]. Cytokine 39 (1) , p. 14. 10.1016/j.cyto.2007.07.053

Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Richards, Peter James, Thomas, Eleri, Carty, Sara Madelaine, Nowell, Mari Ann, Goodfellow, Rhian Mair, Dent, Colin Michael, Williams, Bryan Davies, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas 2007. Interferon-γ protects against the development of structural damage in experimental arthritis by regulating polymorphonuclear neutrophil influx into diseased joints. Arthritis & Rheumatism 56 (7) , pp. 2244-2254. 10.1002/art.22732

Carty, Sara Madelaine, Nowell, Mari Ann, Lauder, Sarah Nicol, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2007. Combination therapy with etanercept and sgp130 for rheumatoid arthritis is more effective than monotherapy [Abstract]. Rheumatology 46 (s1) , I18-I18. 10.1093/rheumatology/kem1007

Dimitrov, Stoyan, Lange, Tanja, Benedict, Christian, Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Scheller, Jurgen, Rose-John, Stefan and Born, Jan 2006. Sleep enhances IL-6 trans-signaling in humans. The FASEB Journal 20 (12) , pp. 2174-2176. 10.1096/fj.06-5754fje

Carty, Sara Madelaine, Nowell, Mari Ann, Goodfellow, Rhian Mair, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2006. TINFa and IL-6/slL-6R interactions regulate the magnitude and the phenotype of synovial Leucocyte infiltration in rheumatoid arthritis [Abstract]. Arthritis and Rheumatism 54 (9) , S597-S597.

Nowell, Mari Ann, Richards, Peter James, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Ognjanovic, Simona, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Bryant-Greenwood, Gillian and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2006. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis. Arthritis & Rheumatism 54 (7) , pp. 2084-2095. 10.1002/art.21942

Monslow, Jamie, Williams, John David, Fraser, Donald James ORCID: https://orcid.org/0000-0003-0102-9342, Michael, Daryn Robert, Foka, Pelagia, Kift-Morgan, Ann Patricia, Luo, Dong Dong, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Craig, Kathrine Jane, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 and Bowen, Timothy ORCID: https://orcid.org/0000-0001-6050-0435 2006. Sp1 and Sp3 mediate constitutive transcription of the human hyaluronan synthase 2 gene. The Journal of Biological Chemistry 281 (26) , pp. 18043-18050. 10.1074/jbc.M510467200

Peake, N. J., Khawaja, K., Myers, A., Nowell, Mari Ann, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Rowan, A. D., Cawston, T. E. and Foster, H. E. 2006. Interleukin-6 signalling in juvenile idiopathic arthritis is limited by proteolytically cleaved soluble interleukin-6 receptor. Rheumatology 45 (12) , pp. 1485-1489. 10.1093/rheumatology/kel154

Richards, Peter James, Nowell, Mari Ann, Horiuchi, Sankichi, McLoughlin, Rachel Mary, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Grau, Sandra, Yamamoto, Naoki, Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X, Rose-John, Stefan, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2006. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis & Rheumatism 54 (5) , pp. 1662-1672. 10.1002/art.21818

Grau, Sandra, Richards, Peter J., Kerr, Briedgeen, Hughes, Clare Elizabeth ORCID: https://orcid.org/0000-0003-4726-5877, Caterson, Bruce ORCID: https://orcid.org/0000-0001-6016-0661, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Junker, Uwe, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Clausen, Tim and Ehrmann, Michael ORCID: https://orcid.org/0000-0002-1927-260X 2006. The role of human HtrA1 in arthritic disease. The Journal of Biological Chemistry 281 (10) , pp. 6124-6129. 10.1074/jbc.M500361200

Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, McLoughlin, Rachel Mary, Colmont, Chantal Sophie, Kovaleva, Marina, Harris, Dean Anthony, Rose-John, Stefan, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2005. Viral IL-6 blocks neutrophil infiltration during acute inflammation. The Journal of Immunology 175 (6) , pp. 4024-4029.

McLoughlin, Rachel Mary, Jenkins, Brendan J., Grail, Dianne, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153, Parker, Clare R., Ernst, Matthias, Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2005. IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation. Proceedings of the National Academy of Sciences of the United States of America (PNAS) ISSN 1091-6490 102 (27) , pp. 9589-9594. 10.1073/pnas.0501794102

Carty, S. M., Nowell, Mari Ann, Goodfellow, Rhian Mair, Topley, Nicholas, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711, Williams, B. D. and Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X 2005. Interleukin 6 (IL-6) signalling in rheumatoid arthritis. Rheumatology 44 , I38-I38.

McLoughlin, Rachel Mary, Hurst, Suzanne Maria, Nowell, Mari Ann, Harris, Dean Anthony, Horiuchi, Sankichi, Morgan, Llinos Wyn, Yamamoto, Naoki, Wilkinson, Thomas S., Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2004. Differential regulation of neutrophil-activating chemokines by IL-6 and its soluble receptor isoforms. The Journal of Immunology 172 , pp. 5676-83.

Nowell, Mari Ann, Richards, Peter James, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Topley, Nicholas, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2003. Soluble IL-6 receptor governs IL-6 activity in experimental arthritis: blockade of arthritis severity by soluble glycoprotein 130. The Journal of Immunology 171 (6) , pp. 3202-3209.

McLoughlin, Rachel Mary, Witowski, Janusz, Robson, Rachel L., Wilkinson, Thomas S., Hurst, Suzanne Maria, Williams, Anwen Sian ORCID: https://orcid.org/0000-0001-6118-020X, Williams, John David, Rose-John, Stefan, Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas 2003. Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. The Journal of Clinical Investigation 112 (4) , pp. 598-607. 10.1172/JCI200317129

Robson, Rachel L., McLoughlin, Rachel Mary, Witowski, Janusz, Loetscher, Pius, Wilkinson, Thomas S., Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 and Topley, Nicholas 2001. Differential regulation of chemokine production in human peritoneal mesothelial cells: IFN-gamma controls neutrophil migration across the mesothelium in vitro and in vivo. The Journal of Immunology 167 (2) , pp. 1028-1038.

Hurst, Suzanne Maria, Wilkinson, Thomas S., McLoughlin, Rachel Mary, Jones, Suzanne, Horiuchi, Sankichi, Yamamoto, Naoki, Rose-John, Stefan, Fuller, Gerald M., Topley, Nicholas and Jones, Simon Arnett ORCID: https://orcid.org/0000-0001-7297-9711 2001. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity 14 (6) , pp. 705-714. 10.1016/S1074-7613(01)00151-0