CACNA1C: Association with pychiatric disorders, behavior, and neurogenesis

Moon, Anna L. ORCID: https://orcid.org/0000-0002-6587-4425, Haan, Niels, Wilkinson, Lawrence S. ORCID: https://orcid.org/0000-0002-9337-6124, Thomas, Kerrie L. ORCID: https://orcid.org/0000-0003-3355-9583 and Hall, Jeremy ORCID: https://orcid.org/0000-0003-2737-9009 2018. CACNA1C: Association with pychiatric disorders, behavior, and neurogenesis. Schizophrenia Bulletin 44 (5) , pp. 958-965. 10.1093/schbul/sby096

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Abstract

Large-scale genome-wide association studies have consistently shown that genetic variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit alpha1C, increases risk for psychiatric disorders. CACNA1C encodes the Cav1.2 subunit of voltage-gated calcium channels, which themselves have been functionally implicated in a broad spectrum of neuropsychiatric syndromes. Research has concentrated on uncovering the underlying biological mechanisms that could be responsible for this increased risk. This review presents an overview of recent findings regarding Cacna1c variation in animal models, particularly focusing on behavioral phenotypes associated with neurodevelopmental disorders such as cognition, anxiety and depressive phenotypes, and fear conditioning. The impact of reduced gene dosage of Cacna1c on adult hippocampal neurogenesis is also assessed, including new data from a novel Cacna1c+/− rat model.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Biosciences Medicine Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Oxford University Press
ISSN:	0586-7614
Date of First Compliant Deposit:	19 July 2018
Date of Acceptance:	12 June 2018
Last Modified:	21 Nov 2024 10:00
URI:	https://orca.cardiff.ac.uk/id/eprint/113266

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