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Short total synthesis of ajoene

Silva, Filipa, Khokhar, Shaista S., Williams, Danielle M., Saunders, Robert, Evans, Gareth J. S., Graz, Michael and Wirth, Thomas 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57 (38) , pp. 12290-12293. 10.1002/anie.201808605

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We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable protocol for the synthesis of ajoene from simple building blocks also suitable for upscale operations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Wiley
ISSN: 1433-7851
Funders: EPSRC
Date of First Compliant Deposit: 15 August 2018
Date of Acceptance: 6 August 2018
Last Modified: 24 Sep 2020 16:15

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