Short total synthesis of ajoene

Silva, Filipa, Khokhar, Shaista S., Williams, Danielle M., Saunders, Robert, Evans, Gareth J. S., Graz, Michael and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2018. Short total synthesis of ajoene. Angewandte Chemie International Edition 57 (38) , pp. 12290-12293. 10.1002/anie.201808605

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Abstract

We describe a short total synthesis of ajoene, a major biologically active constituent of garlic. The instability of allicin as the only other known alternative starting material has led to the development of a reliable protocol for the synthesis of ajoene from simple building blocks also suitable for upscale operations.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Funders:	EPSRC
Date of First Compliant Deposit:	15 August 2018
Date of Acceptance:	6 August 2018
Last Modified:	05 May 2023 01:04
URI:	https://orca.cardiff.ac.uk/id/eprint/114186

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