The diverse family of MR1-restricted T cells

Gherardin, Nicholas A., McCluskey, James, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 and Godfrey, Dale I. 2018. The diverse family of MR1-restricted T cells. The Journal of Immunology 201 (10) , pp. 2862-2871. 10.4049/jimmunol.1801091

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Abstract

Mucosal-associated invariant T (MAIT) cells are characterized by a semi-invariant TCR that recognizes vitamin B metabolite Ags presented by the MHC-related molecule MR1. Their Ag restriction determines a unique developmental lineage, imbuing a tissue-homing, preprimed phenotype with antimicrobial function. A growing body of literature indicates that MR1-restricted T cells are more diverse than the MAIT term implies. Namely, it is increasingly clear that TCR α- and TCR β-chain diversity within the MR1-restricted repertoire provides a potential mechanism of Ag discrimination, and context-dependent functional variation suggests a role for MR1-restricted T cells in diverse physiological settings. In this paper, we summarize MR1-restricted T cell biology, with an emphasis on TCR diversity, Ag discrimination, and functional heterogeneity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Association of Immunologists
ISSN:	0022-1767
Date of Acceptance:	21 August 2018
Last Modified:	24 Oct 2022 08:19
URI:	https://orca.cardiff.ac.uk/id/eprint/117410

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