Casini, Angela  ORCID: https://orcid.org/0000-0003-1599-9542, Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384 and Oberkofler, Jens
2018.
Organometallic gold-based anticancer therapeutics.
Reference Module in Chemistry, Molecular Sciences and Chemical Engineering,
Elsevier,
pp. 1-10.
(10.1016/B978-0-12-409547-2.14350-1)
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Abstract
The application of gold in medicine is traceable for several thousand years, and recently, research into gold-based drugs for a number of human diseases has seen a renaissance. Within this research area, organometallic gold complexes have been particularly explored as anticancer therapeutics, mainly due to their higher stability in physiological conditions guaranteed by the presence of a direct Au-C bond. In this specialized contribution, a selection of the main results obtained on the synthesis, chemical properties and biological activities of two of the most explored families of organometallics—namely, Au(I) N-heterocyclic carbenes (NHCs) and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action are also discussed, which constitute the basis for future drug design.
| Item Type: | Book Section |
|---|---|
| Date Type: | Published Online |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | Elsevier |
| ISBN: | 9780124095472 |
| Date of First Compliant Deposit: | 20 December 2018 |
| Date of Acceptance: | 22 October 2018 |
| Last Modified: | 23 Jan 2024 08:55 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/117865 |
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