Organometallic gold-based anticancer therapeutics

Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542, Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384 and Oberkofler, Jens 2018. Organometallic gold-based anticancer therapeutics. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Elsevier, pp. 1-10. (10.1016/B978-0-12-409547-2.14350-1)

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Abstract

The application of gold in medicine is traceable for several thousand years, and recently, research into gold-based drugs for a number of human diseases has seen a renaissance. Within this research area, organometallic gold complexes have been particularly explored as anticancer therapeutics, mainly due to their higher stability in physiological conditions guaranteed by the presence of a direct Au-C bond. In this specialized contribution, a selection of the main results obtained on the synthesis, chemical properties and biological activities of two of the most explored families of organometallics—namely, Au(I) N-heterocyclic carbenes (NHCs) and cyclometalated Au(III) compounds—is presented. Their structure-activity relationships and information on their modes of action are also discussed, which constitute the basis for future drug design.

Item Type:	Book Section
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Publisher:	Elsevier
ISBN:	9780124095472
Date of First Compliant Deposit:	20 December 2018
Date of Acceptance:	22 October 2018
Last Modified:	23 Jan 2024 08:55
URI:	https://orca.cardiff.ac.uk/id/eprint/117865

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