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Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors

Glaxo Group Limited 2003. Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors. WO2003068771A1. [Patent].

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Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and === is a double bond; or X is CH, Y is CH2 or oxygen and === is a single bond; or X is nitrogen, Y is CH2 And === is a single bond; R1is halogen, cyano, or C1-6 alkoxy; a is 0, 1, 2 or 3; b is 0 or 1; R2 is hydrogen, C1-6 alkyl, C1-6 alkanoyl, fluoroC1-6 alkanoyl, C1-6 alkylsulfonyl, fluoroC1-6 alkylsulfonyl, carbamoyl, C1-6 alkylcarbamoyl or arylC1-6 alkyl; and R3, together with the nitrogen atom to which it is attached, forms an optionally substituted 5 to 7 membered heterocyclic group fused to the benzene ring. Methods of preparing the compounds and uses of the compounds in therapy, in particular for a CNS disorder such as depression or anxiety, are also disclosed.

Item Type: Patent
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Heterocyclymethylpiperidines; piperazines
Last Modified: 12 Mar 2019 11:40

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