Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors

Glaxo Group Limited 2003. Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors. WO2003068771A1. [Patent].

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Abstract

Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed, wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl, isoquinolinyl or benzofuranyl; X is carbon, Y is CH and === is a double bond; or X is CH, Y is CH2 or oxygen and === is a single bond; or X is nitrogen, Y is CH2 And === is a single bond; R1is halogen, cyano, or C1-6 alkoxy; a is 0, 1, 2 or 3; b is 0 or 1; R2 is hydrogen, C1-6 alkyl, C1-6 alkanoyl, fluoroC1-6 alkanoyl, C1-6 alkylsulfonyl, fluoroC1-6 alkylsulfonyl, carbamoyl, C1-6 alkylcarbamoyl or arylC1-6 alkyl; and R3, together with the nitrogen atom to which it is attached, forms an optionally substituted 5 to 7 membered heterocyclic group fused to the benzene ring. Methods of preparing the compounds and uses of the compounds in therapy, in particular for a CNS disorder such as depression or anxiety, are also disclosed.

Item Type:	Patent
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Heterocyclymethylpiperidines; piperazines
Last Modified:	25 Oct 2022 13:16
URI:	https://orca.cardiff.ac.uk/id/eprint/119389

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