Kannen, Vinicius, Parry, Lee ![]() |
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Official URL: http://dx.doi.org/10.1016/j.trecan.2019.08.002
Abstract
Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences European Cancer Stem Cell Research Institute (ECSCRI) |
Publisher: | Elsevier |
ISSN: | 2405-8033 |
Date of First Compliant Deposit: | 2 September 2019 |
Date of Acceptance: | 16 August 2019 |
Last Modified: | 06 Nov 2023 19:48 |
URI: | https://orca.cardiff.ac.uk/id/eprint/125226 |
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