Phages enter the fight against colorectal cancer

Kannen, Vinicius, Parry, Lee ORCID: https://orcid.org/0000-0002-4467-9196 and Martin, Francis L. 2019. Phages enter the fight against colorectal cancer. Trends in Cancer 5 (10) , pp. 577-579. 10.1016/j.trecan.2019.08.002

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Abstract

Intestinal microbiota undergo significant changes in colorectal cancer (CRC). Zheng et al. (Nat. Biomed. Eng., 2019) observe detrimental overpopulation of Fusobacterium nucleatum in mice and patients, suppressing the beneficial butyrate-producing Clostridium butyricum. Phage-guided irinotecan-loaded dextran nanoparticles promote release of bacterial-derived butyrate, while F. nucleatum and CRC cells are eliminated. These findings describe a possible novel therapeutic strategy for CRC.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences European Cancer Stem Cell Research Institute (ECSCRI)
Publisher:	Elsevier
ISSN:	2405-8033
Date of First Compliant Deposit:	2 September 2019
Date of Acceptance:	16 August 2019
Last Modified:	06 Nov 2023 19:48
URI:	https://orca.cardiff.ac.uk/id/eprint/125226

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