Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids

Demiray, Melodi, Miller, David J and Allemann, Rudolf K ORCID: https://orcid.org/0000-0002-1323-8830 2019. Harnessing enzyme plasticity for the synthesis of oxygenated sesquiterpenoids. Beilstein Journal of Organic Chemistry 15 , pp. 2184-2190. 10.3762/bjoc.15.215

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Abstract

8-Methoxy-γ-humulene, (E)-8-methoxy-β-farnesene, 12-methoxy-β-sesquiphellandrene and 12-methoxyzingiberene can be synthesised in amorphadiene synthase-catalysed reactions from 8- and 12-methoxyfarnesyl diphosphates due to the highly plastic yet tightly controlled carbocationic chemistry of this sesquiterpene cyclase.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Beilstein-Institut
ISSN:	1860-5397
Date of First Compliant Deposit:	1 October 2019
Date of Acceptance:	26 August 2019
Last Modified:	03 May 2023 20:08
URI:	https://orca.cardiff.ac.uk/id/eprint/125816

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