Gruden, M. A, Davydova, T. V, Fomina, V. G, Vetrile, L. A, Morozova-Roche, L. A and Sewell, Robert 2017. Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 162 (4) , pp. 430-432. 10.1007/s10517-017-3632-2 |
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Official URL: http://dx.doi.org/10.1007/s10517-017-3632-2
Abstract
Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Pharmacy |
Subjects: | R Medicine > RM Therapeutics. Pharmacology |
Uncontrolled Keywords: | amnesia; S100A9 fibrils; glutamate antibodies; spatial memory; locomotor |
Publisher: | Springer Verlag (Germany) |
ISSN: | 0007-4888 |
Date of First Compliant Deposit: | 22 October 2019 |
Date of Acceptance: | 26 October 2016 |
Last Modified: | 06 Nov 2023 22:19 |
URI: | https://orca.cardiff.ac.uk/id/eprint/126190 |
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