Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice

Gruden, M. A, Davydova, T. V, Fomina, V. G, Vetrile, L. A, Morozova-Roche, L. A and Sewell, Robert 2017. Antibodies to glutamate reversed the amnesic effects of proinflammatory S100A9 protein fibrils in aged C57Bl/6 mice. Bulletin of Experimental Biology and Medicine 162 (4) , pp. 430-432. 10.1007/s10517-017-3632-2

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Abstract

Chronic intranasal administration of fibrillar structures of proinflammatory S100A9 protein impaired passive avoidance learning in old C57Bl/6 mice. Combined treatment with S100A9 fibrils and antibodies to glutamate was followed by an increase in horizontal locomotor activity of animals in the open-field test and did not disturb spatial memory.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	amnesia; S100A9 fibrils; glutamate antibodies; spatial memory; locomotor
Publisher:	Springer Verlag (Germany)
ISSN:	0007-4888
Date of First Compliant Deposit:	22 October 2019
Date of Acceptance:	26 October 2016
Last Modified:	01 Dec 2024 21:15
URI:	https://orca.cardiff.ac.uk/id/eprint/126190

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