The potential of probiotics in the prevention and treatment of atherosclerosis

O'Morain, Victoria and Ramji, Dipak P. ORCID: https://orcid.org/0000-0002-6419-5578 2020. The potential of probiotics in the prevention and treatment of atherosclerosis. Molecular Nutrition and Food Research 64 (4) , 1900797. 10.1002/mnfr.201900797

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Abstract

Atherosclerosis, the underlying cause of cardiovascular diseases such as myocardial infarction, cerebrovascular accident and peripheral vascular disease, is the leading cause of global mortality. Current therapies against atherosclerosis, which mostly target the dyslipidemia associated with the disease, have considerable residual risk for cardiovascular disease together with various side effects. In addition, the outcomes from clinical trials on many promising pharmaceutical agents against atherosclerosis (e.g., low‐dose methotrexate, inhibitors against cholesteryl ester transfer protein) have been disappointing. Nutraceuticals such as probiotic bacteria have therefore generated substantial recent interest for the prevention of atherosclerosis and potentially as add‐ons with current pharmaceutical drugs. This review will discuss our current understanding of the anti‐atherogenic actions of probiotics from pre‐clinical and clinical studies together with their potential underlying mechanisms of action.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Wiley
ISSN:	1613-4125
Funders:	KESS
Date of First Compliant Deposit:	7 November 2019
Date of Acceptance:	28 October 2019
Last Modified:	01 Dec 2024 22:15
URI:	https://orca.cardiff.ac.uk/id/eprint/126659

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