Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis

Bender, Lena, Boostrom, Hannah M. ORCID: https://orcid.org/0000-0002-7367-3631, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Zuanon, Marika, Celiksoy, Vildan, Sloan, Alastair ORCID: https://orcid.org/0000-0002-1791-0903, Cowpe, Jonathan and Heard, Charles M ORCID: https://orcid.org/0000-0001-9703-9777 2020. A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. European Journal of Pharmaceutics and Biopharmaceutics 149 , pp. 85-94. 10.1016/j.ejpb.2020.01.007

[thumbnail of A+Novel+Dual+Action+Monolithic+Thermosetting+Hydrogel+Loaded+With+Lidocaine+And+Metronidazole+As+a+Potential+Treatment+For+Alveolar+Osteitis.docx.doc.pdf] PDF - Accepted Post-Print Version
Download (593kB)

Abstract

Alveolar osteitis is a complication that can occur after tooth extraction, whereby exposed bone results in severe throbbing pain for the patient and can be prone to infection. The current treatment options are widely regarded as sub-optimal. The aim of this project was to investigate in vitro the plausibility of a dual-action monolithic drug-loaded thermosensitive hydrogel that undergoes thermal gelation within the tooth socket and releases both anaesthetic and antimicrobial agents. Hydrogels containing different levels of lidocaine HCl and metronidazole were prepared based upon Carbopol 934P NF and Pluronic F-127 blends. Membrane-less drug release was determined from the set hydrogels into phosphate buffered saline (PBS) at 37 °C as a function of time, following analysis by HPLC. Gelation characteristics and hydrogel dissolution characteristics were also determined. At 23.38% Pluronic F-127, sol-gel transition commenced at 23 °C and gelation was completely at 37 °C (physiological temperature). Setting times varied with Pluronic content and there was an inverse relationship between drug release and Pluronic content. Sustained and dose dependent release of both drugs was observed at therapeutically relevant levels over 24 h, via a combination of diffusion, dissolution and surface erosion processes. Based on the amounts of drugs released, it was determined that hydrogels containing up to 0.5% lidocaine and 0.1% metronidazole exhibited low risk of cytotoxicity to primary human gingival fibroblasts. In an in vivo scenario, the sol-phase formulation would make contact with all inner surfaces of a tooth socket prior to transitioning to monolithic gel-phase and provide sustained release of lidocaine and metronidazole at sub-toxic levels, thereby providing simultaneous pain relief, protection from ingress of debris and potentially pathological bacteria.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Pharmacy
Publisher: Elsevier
ISSN: 0939-6411
Date of First Compliant Deposit: 29 January 2020
Date of Acceptance: 18 January 2020
Last Modified: 28 Mar 2024 17:32
URI: https://orca.cardiff.ac.uk/id/eprint/129168

Citation Data

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics