Browse by Current Cardiff authors

Lohana, Parkash, Suryaprawira, Albert, Woods, Emma L., Dally, Jordanna, Gait-Carr, Edward, Alaidaroos, Nadia Y.A., Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777, Lee, Kwok Y., Ruge, Fiona, Farrier, Jeremy N., Enoch, Stuart, Caley, Matthew P., Peake, Matthew A., Davies, Lindsay C. ORCID: https://orcid.org/0000-0002-4876-6270, Giles, Peter J. ORCID: https://orcid.org/0000-0003-3143-6854, Thomas, David W. ORCID: https://orcid.org/0000-0001-7319-5820, Stephens, Phil ORCID: https://orcid.org/0000-0002-0840-4996 and Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 2023. Role of enzymic antioxidants in mediating oxidative stress and contrasting wound healing capabilities in oral mucosal/skin fibroblasts and tissues. Antioxidants 12 (7) , 1374. 10.3390/antiox12071374

Celiksoy, Vildan, Moses, Rachael L., Sloan, Alastair J. ORCID: https://orcid.org/0000-0002-1791-0903, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2022. Synergistic activity of pomegranate rind extract and Zn (II) against Candida albicans under planktonic and biofilm conditions, and a mechanistic insight based upon intracellular ROS induction. Scientific Reports 12 , 19560. 10.1038/s41598-022-21995-7

Bergonzi, Maria Camilla, Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 and Garcia-Pardo, Javier 2022. Bioactive molecules from plants: discovery and pharmaceutical applications. Pharmaceutics 14 (10) , 2116. 10.3390/pharmaceutics14102116

Wong, Anepmete, Fallon, Melissa, Celiksoy, Vildan, Ferla, Salvatore, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Whitaker, David, Quantock, Andrew J. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2022. A composite system based upon hydroxypropyl cyclodextrins and soft hydrogel contact lenses for the delivery of therapeutic doses of econazole to the cornea, in vitro. Pharmaceutics 14 (8) , e1631. 10.3390/pharmaceutics14081631

Alrashidi, Amal, Jafar, Mohammed, Higgins, Niamh, Mulligan, Ciara, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Celiksoy, Vildan, Houston, David MJ and Heard, Charles M ORCID: https://orcid.org/0000-0001-9703-9777 2021. A time-kill assay study on the synergistic bactericidal activity of pomegranate rind extract and Zn (II) against Methicillin-resistant Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa. Biomolecules 11 (12) , 1889. 10.3390/biom11121889

Yonbawi, Ahmed R., Abdallah, Hossam M., Alkhilaiwi, Faris A., Koshak, Abdulrahman E. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2021. Anti-Proliferative, Cytotoxic and Antioxidant Properties of the Methanolic Extracts of Five Saudi Arabian Flora with Folkloric Medicinal Use: Aizoon canariense, Citrullus colocynthis, Maerua crassifolia, Rhazya stricta and Tribulus macropterus. Plants 10 (10) , 2073. 10.3390/plants10102073

Celiksoy, Vildan, Moses, Rachael L., Sloan, Alastair J. ORCID: https://orcid.org/0000-0002-1791-0903, Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2021. Synergistic in vitro antimicrobial activity of pomegranate rind extract and zinc (II) against Micrococcus luteus under planktonic and biofilm conditions. Pharmaceutics 13 (6) , 851. 10.3390/pharmaceutics13060851

Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Beirne, Kathy, Aeschlimann, Pascale, Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777, Rozanowska, Malgorzata ORCID: https://orcid.org/0000-0003-2913-8954, Votruba, Marcela ORCID: https://orcid.org/0000-0002-7680-9135 and Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 2020. Discovery of Novel 2-Aniline-1,4-naphthoquinones as potential new drug treatment for Leber’s hereditary optic neuropathy (LHON). Journal of Medicinal Chemistry 63 (22) , 13638 -13655. 10.1021/acs.jmedchem.0c00942

Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. An ex vivo skin model to probe modulation of local cutaneous arachidonic acid inflammation pathway. Journal of Biological Methods 7 (4) , e138. 10.14440/jbm.2020.319

Celiksoy, Vildan, Moses, Rachael L., Sloan, Alastair J., Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. Evaluation of the in vitro oral wound healing effects of pomegranate (Punica granatum) rind extract and punicalagin, in combination with Zn (II). Biomolecules 10 (9) , 1234. 10.3390/biom10091234

Varricchio, C. ORCID: https://orcid.org/0000-0002-1673-4768, Beirne, K., Heard, C. ORCID: https://orcid.org/0000-0001-9703-9777, Newland, B. ORCID: https://orcid.org/0000-0002-5214-2604, Rozanowska, M. ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, A. ORCID: https://orcid.org/0000-0002-9728-3419 and Votruba, M. ORCID: https://orcid.org/0000-0002-7680-9135 2020. The ying and yang of idebenone: Not too little, not too much - cell death in NQO1 deficient cells and the mouse retina. Free Radical Biology and Medicine 152 , pp. 551-560. 10.1016/j.freeradbiomed.2019.11.030

Bender, Lena, Boostrom, Hannah M. ORCID: https://orcid.org/0000-0002-7367-3631, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Zuanon, Marika, Celiksoy, Vildan, Sloan, Alastair ORCID: https://orcid.org/0000-0002-1791-0903, Cowpe, Jonathan and Heard, Charles M ORCID: https://orcid.org/0000-0001-9703-9777 2020. A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. European Journal of Pharmaceutics and Biopharmaceutics 149 , pp. 85-94. 10.1016/j.ejpb.2020.01.007

Morgan, Sian R., Pilia, Nicole, Hewitt, Melissa, Moses, Rachael L., Moseley, Ryan ORCID: https://orcid.org/0000-0002-2812-6735, Lewis, Philip N. ORCID: https://orcid.org/0000-0002-3353-0708, Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908, Kelly, Steven L., Parker, Josie E., Whitaker, David ORCID: https://orcid.org/0000-0002-8271-7552, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. International Journal of Pharmaceutics 579 , 119102. 10.1016/j.ijpharm.2020.119102

Hewitt, Melissa G., Morrison, Peter W. J. ORCID: https://orcid.org/0000-0002-3712-7908, Boostrom, Hannah M. ORCID: https://orcid.org/0000-0002-7367-3631, Morgan, Siân R., Fallon, Melissa ORCID: https://orcid.org/0000-0002-0267-3829, Lewis, Philip N. ORCID: https://orcid.org/0000-0002-3353-0708, Whitaker, David ORCID: https://orcid.org/0000-0002-8271-7552, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419, Varricchio, Carmine ORCID: https://orcid.org/0000-0002-1673-4768, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120, Burton, Matthew J. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. In Vitro Topical Delivery of Chlorhexidine to the Cornea: Enhancement Using Drug-Loaded Contact Lenses and β-Cyclodextrin Complexation, and the Importance of Simulating Tear Irrigation. Molecular Pharmaceutics 17 (4) , pp. 1428-1441. 10.1021/acs.molpharmaceut.0c00140

Yee Lim, Sim, Dafydd, Mali, Ong, Jee, Ord-McDermott, Launa A., Board-Davies, Emma, Sands, Kirsty, Williams, David ORCID: https://orcid.org/0000-0002-7351-5131, Sloan, Alastair J. ORCID: https://orcid.org/0000-0002-1791-0903 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2020. Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases. International Journal of Pharmaceutics 573 , 118860. 10.1016/j.ijpharm.2019.118860

Pasqualetto, Gaia, Pileggi, Elisa, Schepelmann, Martin ORCID: https://orcid.org/0000-0002-7017-5426, Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777, Young, Mark Thomas ORCID: https://orcid.org/0000-0002-9615-9002, Rozanowska, Malgorzata B. ORCID: https://orcid.org/0000-0003-2913-8954, Brancale, Andrea ORCID: https://orcid.org/0000-0002-9728-3419 and Bassetto, Marcella 2019. Novel small-molecule chaperones to overcome opsin misfolding, mistrafficking and aggregation in retinal blinding diseases. Presented at: 2019 ARVO Annual Meeting, Vancouver, Canada, 28 April - 02 May 2019. Investigative ophthalmology & visual science. , vol.60 (9) ARVO,

Barbieri, Mirko and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2019. Isolation of punicalagin from Punica granatum rind extract using mass-directed semi-preparative ESI-AP single quadrupole LC-MS. Journal of Pharmaceutical and Biomedical Analysis 166 , pp. 90-94. 10.1016/j.jpba.2018.12.033

Yurdasiper, Aysu, Ertan, Gokhan and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2018. Enhanced delivery of naproxen to the viable epidermis from an activated poly N-isopropylacrylamide (PNIPAM) Nanogel: Skin penetration, modulation of COX-2 expression and rat paw Oedema. Nanomedicine: Nanotechnology, Biology and Medicine 14 (7) , pp. 2051-2059. 10.1016/j.nano.2018.05.017

Davison, Zoë, Nicholson, Robert I., Hiscox, Stephen ORCID: https://orcid.org/0000-0003-0105-2702 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2018. Co-administration of fish oil with signal transduction inhibitors has anti-migration effects in breast cancer cell lines, in vitro. The Open Biochemistry Journal 12 (1) , pp. 130-148. 10.2174/1874091X01812010130

Zulfakar, Mohd Hanif, Chan, Lee Mei, Rehman, Khurram, Wai, Lam Kok and Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777 2018. Coenzyme Q10-loaded fish oil-based Bigel System: probing the delivery across porcine skin and possible interaction with fish oil fatty acids. AAPS PharmSciTech 19 (3) , pp. 1116-1123. 10.1208/s12249-017-0923-x

Houston, David M. J., Bugert, Joachim J. ORCID: https://orcid.org/0000-0002-0556-3211, Denyer, Stephen P. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2017. Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV. PLoS ONE 12 (6) , e0179291. 10.1371/journal.pone.0179291

Houston, David, Bugert, Joachim ORCID: https://orcid.org/0000-0002-0556-3211, Denyer, Stephen P. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2017. Anti-inflammatory activity of Punica granatum L. (Pomegranate) rind extracts applied topically to ex vivo skin. European Journal of Pharmaceutics and Biopharmaceutics 112 , pp. 30-37. 10.1016/j.ejpb.2016.11.014

Houston, David M. J., Robins, Bethan, Bugert, Joachim J., Denyer, Stephen P. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2017. In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection. European Journal of Pharmaceutical Sciences 96 , pp. 99-106. 10.1016/j.ejps.2016.08.013

Chan, Wendy, Akhbanbetova, Alina, Quantock, Andrew J. ORCID: https://orcid.org/0000-0002-2484-3120 and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2016. Topical delivery of a Rho-kinase inhibitor to the cornea via mucoadhesive film. European Journal of Pharmaceutical Sciences 91 , pp. 256-264. 10.1016/j.ejps.2016.05.016

Zulfakar, Mohd Hanif, Porter, Rebecca and Heard, Charles ORCID: https://orcid.org/0000-0001-9703-9777 2016. In vivoresponse of GsdmA3Dfl/+ mice to topically applied fish oil - effects on cellular markers and macrophages. FEBS Open Bio 6 (8) , pp. 827-834. 10.1002/2211-5463.12095

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2015. Ethanol and other alcohols: old enhancers, alternative perspectives. Dragicevic, Nina and Maibach, Howard I., eds. Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement: Modification of the Stratum Corneum, Springer, pp. 151-172. (10.1007/978-3-662-47039-8_10)

Abu Samah, Nor Hayati and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2014. The effects of topically applied polyNIPAM-based nanogels and their monomers on skin cyclooxygenase expression,ex vivo. Nanotoxicology 8 (1) , pp. 100-106. 10.3109/17435390.2012.754511

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Brain, Keith Roger 2014. Chiral separations. Street, G., ed. Highly selective separations in biotechnology, London: Blackie Academic and Professional, pp. 179-206.

Lau, Wing Man, Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158 2013. Design, synthesis and in vitro degradation of a novel co-drug for the treatment of psoriasis. Pharmaceutics 5 (2) , pp. 232-245. 10.3390/pharmaceutics5020232

Abu Samah, Nor Hayati and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2013. Enhanced in vitro transdermal delivery of caffeine using a temperature- and pH-sensitive nanogel, poly(NIPAM-co-AAc). International Journal of Pharmaceutics 453 (2) , pp. 630-640. 10.1016/j.ijpharm.2013.05.042

Wallace, Eleri, Ong, Charlene M. Y. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2012. Delivery of atovaquone and proguanil across sublingual membranes, in vitro. Pharmaceutical Development and Technology 17 (6) , pp. 770-776. 10.3109/10837450.2011.580760

Lau, Wing Man, Ng, Keng Wooi, Sakenyte, Kristina and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2012. Distribution of esterase activity in porcine ear skin, and the effects of freezing and heat separation. International Journal of Pharmaceutics 433 (1-2) , pp. 10-15. 10.1016/j.ijpharm.2012.04.079

Zulfakar, Mohd Hanif, Ong, Charlene M.Y and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2012. The effects of betamethasone dipropionate and fish oil on HaCaT proliferation and apoptosis. International Journal of Pharmaceutics 434 (1-2) , pp. 399-405. 10.1016/j.ijpharm.2012.06.008

Abu Samah, Nor Hayati and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2011. Topically applied KTTKS: a review. International Journal of Cosmetic Science 33 (6) , pp. 483-490. 10.1111/j.1468-2494.2011.00657.x

Zulfakar, Mohd Hanif, Alex, Aneesh, Povazay, Boris, Drexler, Wolfgang, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Porter, Rebecca M. ORCID: https://orcid.org/0000-0001-6748-0916 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2011. In vivo response of GsdmA3Dfl/+ mice to topically applied anti-psoriatic agents: effects on epidermal thickness, as determined by optical coherence tomography and H&E staining. Experimental Dermatology 20 (3) , pp. 269-272. 10.1111/j.1600-0625.2010.01233.x

Lau, Wing Man ORCID: https://orcid.org/0000-0002-2998-6470, Ng, Keng Wooi ORCID: https://orcid.org/0000-0003-2541-4763, White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2011. Therapeutic and cytotoxic effects of the novel antipsoriasis codrug, naproxyl-dithranol, on HaCaT cells. Molecular Pharmaceutics 8 (6) , pp. 2398-2407. 10.1021/mp200327k

Singka, Gillian S. L., Abu Samah, Nor H., Zulfakar, Mohd, Yurdasiper, A. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Enhanced topical delivery and anti-inflammatory activity of methotrexate from an activated nanogel. European Journal of Pharmaceutics and Biopharmaceutics 76 (2) , pp. 275-281. 10.1016/j.ejpb.2010.06.014

Davison, Zoë, Nicholson, Robert I., Denyer, Stephen P. and Heard, Charles M. ORCID: https://orcid.org/0000-0001-9703-9777 2010. A novel diffusion cell model for the in vitro assessment of transcutaneous breast cancer therapeutics: effect of permeants on MCF-7 cells cultured within the receptor compartment. European Journal Of Pharmaceutics and Biopharmaceutics 75 (3) , pp. 411-417. 10.1016/j.ejpb.2010.03.019

Lau, Wing Man ORCID: https://orcid.org/0000-0002-2998-6470, White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158, Donaldson, M. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Histochemical visualisation of esterase activity in porcine ear skin. Journal of Pharmacy and Pharmacology 62 (6) , p. 798. 10.1211/jpp.62.06.0016

Searby, Caroline, Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Porter, Rebecca Mary ORCID: https://orcid.org/0000-0001-6748-0916 2010. Sonic hedgehog is not enough to create basal cell carcinoma in vitro. British Journal of Dermatology 162 (4) , p. 923. 10.1111/j.1365-2133.2010.09700.x

Abdelouahab, Nassima and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Estimation of the Relative Antiinflammatory Efficacies of Six Commercial Preparations of Harpagophytum procumbens (Devil's Claw). Phytotherapy Research 24 (3) , pp. 333-338. 10.1002/ptr.2930

Ballam, L. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Pre-Treatment with Aloe vera Juice Does Not Enhance the in vitro Permeation of Ketoprofen across Skin. Skin Pharmacology and Physiology 23 (2) , pp. 113-116. 10.1159/000265682

Lee, L. M., Davison, Zoe and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. In vitro delivery of anti-breast cancer agents directly via the mammary papilla (nipple). International Journal of Pharmaceutics 387 (1-2) , pp. 161-166. 10.1016/j.ijpharm.2009.12.021

Zulfakar, Modh Hanif, Abdelouahab, Nassima and Heard, Christopher Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil. Inflammation Research 59 (1) , pp. 23-30. 10.1007/s00011-009-0065-z

Lau, Wing Man ORCID: https://orcid.org/0000-0002-2998-6470, White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Topical delivery of a naproxen-dithranol co-drug: in vitro skin penetration, permeation, and staining. Pharmaceutical Research 27 (12) , pp. 2734-2742. 10.1007/s11095-010-0274-8

Samah, Nor Abu, Williams, Nicholas and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2010. Nanogel particulates located within diffusion cell receptor phases following topical application demonstrates uptake into and migration across skin. International Journal of Pharmaceutics 401 (1-2) , pp. 72-78. 10.1016/j.ijpharm.2010.08.011

Davison, Zoe, Nicholson, Robert Ian, Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Denyer, Stephen Paul and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2009. Control of microbial contamination of Franz diffusion cell receptor phase in the development of transcutaneous breast cancer therapeutics. Letters in Applied Microbiology 49 (4) , pp. 456-460. 10.1111/j.1472-765X.2009.02685.x

Abdelouahab, Nassima and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2009. A novel ex vivo skin model for the assessment of the potential transcutaneous anti-inflammatory effect of topically applied Harpagophytum procumbens extract. International Journal of Pharmaceutics 376 (1-2) , pp. 63-68. 10.1016/j.ijpharm.2009.04.017

Davison, Zoe, Nicholson, Robert Ian, Maillard, Jean Yves ORCID: https://orcid.org/0000-0002-8617-9288, Denyer, Stephen Paul and Heard, Christopher Martin ORCID: https://orcid.org/0000-0001-9703-9777 2009. Control of microbial contamination of Franz diffusion cell receptor phase in the development of transcutaneous breast cancer therapeutics. Letters In Applied Microbiology 49 (4) , pp. 456-460. 10.1111/j.1472-765X.2009.02685.x

Morris, A. P., Brain, Keith Roger and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2009. Skin permeation and ex vivo skin metabolism of O-acyl haloperidol ester prodrugs. International Journal of Pharmaceutics 367 (1-2) , pp. 44-50. 10.1016/j.ijpharm.2008.09.013

Ong, C. M. Y. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2009. Permeation of quinine across sublingual mucosa, in vitro. International Journal of Pharmaceutics 366 (1-2) , pp. 58-64. 10.1016/j.ijpharm.2008.08.048

Davison, Zoe, Dutkowski, Carol Mary, Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Nicholson, Robert Ian and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. In vitro effects on MCF-7 breast cancer cells of signal transduction inhibitor/tamoxifen/eicosapentaenoic acid combinations and their simultaneous delivery across skin. Pharmaceutical Research 25 (11) , pp. 2516-2525. 10.1007/s11095-008-9665-5

Elgorashi, Abubakr S., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Niazy, Esmail M., Noureldin, Osman H. and Pugh, William John 2008. Transdermal delivery enhancement of haloperidol from gel formulations by 1,8-cineole. Journal of Pharmacy and Pharmacology 60 (6) , pp. 689-692. 10.1211/jpp.60.6.0002

Abdelouahab, Nassima and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. Journal of Natural Products 71 (5) , pp. 746-749. 10.1021/np070204u

Abdelouahab, Nassima and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. Dermal and transcutaneous delivery of the major glycoside constituents of Harpagophytum procumbens (Devil's Claw) in vitro. Planta Medica 74 (5) , pp. 527-531. 10.1055/s-2008/1074500

Abdulmajed, K. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. Topical delivery of retinyl ascorbate. Skin Pharmacology and Physiology 21 (1) , pp. 46-49. 10.1159/000111135

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Screen, C. 2008. Probing the permeation enhancement of mefenamic acid by ethanol across full-thickness skin, heat-separated epidermal membrane and heat-separated dermal membrane. International Journal of Pharmaceutics 349 (1-2) , pp. 323-325. 10.1016/j.ijpharm.2007.08.006

Lau, Wing Man ORCID: https://orcid.org/0000-0002-2998-6470, White, Alex William ORCID: https://orcid.org/0000-0002-1539-0158, Gallagher, S. J., Donaldson, M., McNaughton, G. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. Scope and limitations of the co-drug approach to topical drug delivery. Current Pharmaceutical Design 14 (8) , pp. 794-802.

Morris, Andrew ORCID: https://orcid.org/0000-0002-6315-7553, Brain, Keith Roger and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2008. Synthesis of haloperidol prodrugs and their hydrolysis by porcine liver esterase. Drug Metabolism Letters 2 (4) , pp. 275-279. 10.2174/187231208786734111

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 2007. Probing the skin permeation of eicosapentaenoic acid and ketoprofen 2. Comparative depth profiling and metabolism of eicosapentaenoic acid. European Journal of Pharmaceutics and Biopharmaceutics 67 (1) , pp. 156-165. 10.1016/j.ejpb.2006.11.024

Cole, Louise and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2007. Skin permeation enhancement potential of aloe vera and a proposed mechanism of action based upon size exclusion and pull effect. International Journal of Pharmaceutics 333 (1-2) , pp. 10-16. 10.1016/j.ijpharm.2006.09.047

Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Davison, Zoe and Heard, Christopher Martin ORCID: https://orcid.org/0000-0001-9703-9777 2007. Probing the skin permeation of fish oil/EPA and ketoprofen-3. Effects on epidermal COX-2 and LOX. Prostaglandins Leukotrienes & Essential Fatty Acids 76 (6) , pp. 357-362. 10.1016/j.plefa.2007.05.002

Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 and Heard, Christopher Martin ORCID: https://orcid.org/0000-0001-9703-9777 2007. Probing the skin permeation of eicosapentaenoic acid and ketoprofen - 2. Comparative depth profiling and metabolism of eicosapentaenoic acid. European Journal of Pharmaceutics and Biopharmaceutics 67 (1) , pp. 156-165. 10.1016/j.ejpb.2006.11.024

Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Platts, James Alexis ORCID: https://orcid.org/0000-0002-1008-6595, Tatchell, Thomas and Heard, Christopher Martin ORCID: https://orcid.org/0000-0001-9703-9777 2007. Probing the skin permeation of fish oil/EPA and ketoprofen 1. NMR spectroscopy and molecular modelling. International Journal of Pharmaceutics 338 (1-2) , pp. 207-212. 10.1016/j.ijpharm.2007.02.006

Zulfakar, Modh Hanif, Edwards, M. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2007. Is there a role for topically delivered eicosapentaenoic acid in the treatment of psoriasis? European Journal of Dermatology 17 (4) , pp. 284-291. 10.1684/ejd.2007.0201

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Johnson, Sarah, Moss, Gary and Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 2006. In vitro transdermal delivery of caffeine, theobromine, theophylline and catechin from extract of Guarana, Paullinia Cupana. International Journal of Pharmaceutics 317 (1) , pp. 26-31. 10.1016/j.ijpharm.2006.02.042

Richards, Helen, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2006. In-vitro transcutaneous delivery of ketoprofen and polyunsaturated fatty acids from a pluronic lecithin organogel vehicle containing fish oil. African Journal of Pharmacy and Pharmacology 58 (7) , pp. 903-908. 10.1211/jpp.58.7.0004

Bowen, Jenna L. ORCID: https://orcid.org/0000-0003-1964-6832 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2006. Film drying and complexation effects in the simultaneous skin permeation of ketoprofen and propylene glycol from simple gel formulations. International Journal of Pharmaceutics 307 (2) , pp. 251-257. 10.1016/j.ijpharm.2005.10.014

Abdulmajed, Kasem, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2006. Topical delivery of retinyl ascorbate co-drug. 5. in vitro degradation studies. Skin Pharmacology and Physiology 19 (5) , pp. 248-258. 10.1159/000093980

Abdulmajed, Karim, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 60 (10) , pp. 794-795.

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Gallagher, Simon John, Congiatu, Costantino, Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612, Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Nemcova, Marta and Nouskova, Tereza 2005. Preferential π–π complexation between tamoxifen and borage oil/γ linolenic acid: transcutaneous delivery and NMR spectral modulation. International Journal of Pharmaceutics 302 (1-2) , pp. 47-55. 10.1016/j.ijpharm.2005.06.013

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Abdulmajed, K and McCuigan, C 2005. Topical delivery of retinyl ascorbate co-drug: 4. Comparative anti-oxidant activity towards DPPH. Free Radical Research 39 (5) , pp. 491-498. 10.1080/10715760500072263

Abdulmajed, Kasem, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Topical delivery of retinyl ascorbate: 4. comparative anti-oxidant activity towards DPPH. Free Radical Research 39 (5) , pp. 491-498. 10.1080/10715760500072263

Chilcott, R. P., Barai, N., Beezer, A. E., Brain, Sally Innis, Brown, M. B., Bunge, A. L., Burgess, S. E., Cross, S., Dalton, C. H., Dias, M., Farinha, A., Finnin, B. C., Gallagher, Simon John, Green, D. M., Gunt, H., Gwyther, R. L., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Jarvis, C. A., Kamiyama, F., Kasting, G. B., Ley, E. E., Lim, S. T., Mcnaughton, Graham Stephen, Morris, A., Nazemi, Mohammed Husein, Pellett, M. A., Du Plessis, J., Quan, Y. S., Raghavan, S. L., Roberts, M., Romonchuk, W., Roper, C. S., Schenk, D., Simonsen, L., Simpson, A., Traversa, B. D., Trottet, L., Watkinson, A., Wilkinson, S. C., Williams, F. M., Yamamoto, A. and Hadgraft, J. 2005. Inter- and intralaboratory variation of in vitro diffusion cell measurements: an international multicenter study using quasi-standardized methods and materials. Journal of Pharmaceutical Sciences 94 (3) , pp. 632-638. 10.1002/jps.20229

Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. In vitro transcutaneous delivery of ketoprofen and essential polyunsaturated fatty acids from a fish oil vehicle incorporating 1,8-cineole. Drug Delivery 12 (1) , pp. 7-14. 10.1080/10717540590889565

Gallagher, S. J. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2005. Solvent content and macroviscosity effects on the in vitro transcutaneous delivery and skin distribution of ketoprofen from simple gel formulations. Skin Pharmacology and Physiology 18 (4) , pp. 186-194. 10.1159/000085864

Ho, Suzanna, Calder, Richard J., Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2004. In-vitro transcutaneous delivery of tamoxifen and γ-linolenic acid from borage oil containing ethanol and 1,8-cineole. Pharmacy and Pharmacology 56 (11) , pp. 1357-1364. 10.1211/0022357044599

Abdulmajed, K., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Pugh, William John 2004. Topical delivery of retinyl ascorbate co-drug - 2. Comparative skin tissue and keratin binding studies. Skin Pharmacology and Physiology 17 (6) , pp. 274-282. 10.1159/000081112

Batchelder, R. J., Calder, R. J., Thomas, Christopher P. ORCID: https://orcid.org/0000-0001-5840-8613 and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2004. In vitro transdermal delivery of the major catechins and caffeine from extract of Camellia sinensis. International Journal of Pharmaceutics 283 (1-2) , pp. 45-51. 10.1016/j.ijpharm.2004.06.007

Abdulmajed, Kasem and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2004. Topical delivery of retinyl ascorbate co-drug - 1. synthesis, penetration into and permeation across human skin. International Journal of Pharmaceutics 280 (1-2) , pp. 113-124. 10.1016/j.ijpharm.2004.05.008

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Jarvis, Chris A and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2004. In vitro delivery of novel, highly potent anti-varicella zoster virus nucleoside analogues to their target site in the skin. Pharmaceutical Research 21 (6) , pp. 914-919. 10.1023/B:PHAM.0000029277.60760.43

Karia, Clare, Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612, Morris, Andrew and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2004. Simultaneous permeation of tamoxifen and gamma linolenic acid across excised human skin. Further evidence of the permeation of solvated complexes. International Journal of Pharmaceutics 271 (1-2) , pp. 305-309. 10.1016/j.ijpharm.2003.11.017

Gallagher, Simon J., Trottet, Lionel and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Ketoprofen: release from, permeation across and rheology of simple gel formulations that simulate increasing dryness. International Journal of Pharmaceutics 268 (1-2) , pp. 37-45. 10.1016/j.ijpharm.2003.08.012

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Gallagher, Simon John, Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612 and Maguire, Paula B. 2003. The in vitro delivery of NSAIDS across skin was in proportion to the delivery of essential fatty acids in the vehicle - evidence that solutes permeate skin associated with their solvation cages? International Journal of Pharmaceutics 261 (1-2) , pp. 165-169. 10.1016/S0378-5173(03)00297-7

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Enantiomeric resolution of some 2-arylpropionic acids using L(-)-serine-impregnated silica as stationary phase by thin layer chromatography. Journal of Pharmaceutical and Biomedical Analysis 32 (4-5) , pp. 1055-1059. 10.1016/S0731-7085(03)00208-5

Jarvis, C. A., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X 2003. Targeted dermal delivery of highly potent anti-varicella zoster virus nucleoside analogues from saturated solutions and ethanolic oil-in-water creams. Journal of drug targeting 11 (7) , pp. 433-441. 10.1080/1061186042000201990

Aboul-Enein, Hassan Y., El-Awady, Mahmoud I. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Thin layer chromatographic resolution of some 2-arylpropionic acid enantiomers using L-(-)-serine, L-(-)-threonine and a mixture of L-(-)-serine and L-(-)threonine-impregnated silica gel as stationary phases. Biomedical Chromatography 17 (5) , pp. 325-334. 10.1002/bmc.245

Gallagher, S. J., Trottet, L., Carter, T. P. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Effects of membrane type and liquid/liquid phase boundary on in vitro release of ketoprofen from gel formulations. Journal of drug targeting 11 (6) , pp. 373-379. 10.1080/10611860310001636890

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Monk, B and Modley, A. J. 2003. Binding of primaquine to epidermal membranes and keratin. International Journal of Pharmaceutics 257 (1-2) , pp. 237-244. 10.1016/S0378-5173(03)00140-6

Jarvis, Chris, McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2003. Penetration of highly active anti-VZV nucleoside analogues into and through full-thickness skin. Antiviral Research 57 (3) , A68-A68.

Banning, Thomas P. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2002. Binding of doxycycline to keratin, melanin and human epidermal tissue. International Journal of Pharmaceutics 235 (1-2) , pp. 219-227. 10.1016/S0378-5173(01)00988-7

Chedgzoy, P., Winckle, Gareth and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2002. Triclosan: release from transdermal adhesive formulations and in vitro permeation across human epidermal membranes. International Journal of Pharmaceutics 235 (1-2) , pp. 229-236. 10.1016/S0378-5173(01)00992-9

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2002. Direct enantiomeric resolution of some cardiovascular agents using synthetic polymers imprinted with (-)-S-timolol as chiral stationary phase by thin layer chromatography. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 57 (3) , pp. 169-171.

Allender, Christopher John, Richardson, C., Woodhouse, B., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Brain, Keith Roger 2000. Pharmaceutical applications for molecularly imprinted polymers. International Journal of Pharmaceutics 195 (1-2) , pp. 39-43. 10.1016/S0378-5173(99)00355-5

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 2000. Enantiomeric separation of aminoglutethimide, acetyl aminoglutethimide, and dansyl aminoglutethimide by tlc with beta-cyclodextrin and derivatives as mobile phase additives. Journal of Liquid Chromatography and Related Technologies 23 (17) , pp. 2715-2726. 10.1081/JLC-100101829

Aboul-Enein, H. Y., El-Awady, M. I., Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Nicholls, P. J. 1999. Application of thin-layer chromatography in enantiomeric chiral analysis - an overview. Biomedical Chromatography 13 (8) , pp. 531-537. 10.1002/(SICI)1099-0801(199912)13:8<531::AID-BMC921>3.0.CO;2-Q

Perkins, Nia C. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1999. In vitro dermal and transdermal delivery of doxycycline from ethanol/migliol 840 vehicles. International Journal of Pharmaceutics 190 (2) , pp. 155-164. 10.1016/S0378-5173(99)00240-9

Jeans, C. W. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1999. A therapeutic dose of primaquine can be delivered across excised human skin from simple transdermal patches. International Journal of Pharmaceutics 189 (1) , pp. 1-6. 10.1016/S0378-5173(99)00215-X

Suedee, R., Brain, Keith Roger and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1999. Differential permeation of propranolol enantiomers across human skin in vitro from formulations containing an enantioselective excipient. Chirality -New York- 11 (9) , pp. 680-683. 10.1002/(SICI)1520-636X(1999)11:9<680::AID-CHIR2>3.0.CO;2-B

Allender, Christopher John, Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Brain, Keith Roger 1997. Mobile phase effects on enantiomer resolution using molecularly imprinted polymers. Chirality -New York- 9 (3) , pp. 238-242. 10.1002/(SICI)1520-636X(1997)9:3<238::AID-CHIR6>3.0.CO;2-B

Allender, Christopher John, Brain, Keith Roger and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1997. Binding cross-reactivity of Boc-phenylalanine enantiomers on molecularly imprinted polymers. Chirality -New York- 9 (3) , pp. 233-237. 10.1002/(SICI)1520-636X(1997)9:3<233::AID-CHIR5>3.0.CO;2-G

Suedee, R., Brain, Keith Roger and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1997. Enantioselective retardation of rac-propranolol from matrices containing cellulose derivatives. Chirality -New York- 9 (3) , pp. 307-312. 10.1002/(SICI)1520-636X(1997)9:3<307::AID-CHIR18>3.0.CO;2-R

Suedee, R. and Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 1997. Direct resolution of propranolol and bupranolol by thin-layer chromatography using cellulose derivatives as stationary phase. Chirality -New York- 9 (2) , pp. 139-144. 10.1002/(SICI)1520-636X(1997)9:2<139::AID-CHIR11>3.0.CO;2-O

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Suedee, R. 1996. Stereoselective adsorption and trans-membrane transfer of propranolol enantiomers using cellulose derivatives. International Journal of Pharmaceutics 139 (1-2) , pp. 15-23. 10.1016/0378-5173(96)04564-4

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Hadgraft, Jonathan 1996. Ion-pairing interactions between 99mTc-based myocardial imaging agents and oleic acid. Pharmaceutical Research 13 (2) , pp. 316-323.

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777 and Brain, Keith Roger 1995. Does solute stereochemistry influence percutaneous penetration? Chirality -New York- 7 (4) , pp. 305-309.

Heard, Charles Martin ORCID: https://orcid.org/0000-0001-9703-9777, Watkinson, A. C., Brain, Keith Roger and Hadgraft, J. 1993. Invitro skin penetration of propranolol enantiomers. International Journal of Pharmaceutics 90 (3) , R5-R8. 10.1016/0378-5173(93)90202-Q