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Assessing immune responses in the nonobese diabetic mouse model of type 1 Diabetes

Thayer, Terri C., Kakabadse, Dimitri, Boldison, Joanne and Wong, F. Susan 2020. Assessing immune responses in the nonobese diabetic mouse model of type 1 Diabetes. Animal Models of Diabetes, Vol. 2128. Methods in Molecular Biology, New York, NY, USA: Humana Press, pp. 269-289. (10.1007/978-1-0716-0385-7_18)

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Type 1 diabetes is an autoimmune disease resulting in the loss of insulin production and, consequently, hyperglycemia. The nonobese diabetic (NOD) mouse develops spontaneous diabetes with considerable similarity to the disease in humans. Immunological studies using the NOD mouse model allow for the investigation of the natural history of the disease and leukocyte and lymphocyte pathogenic and regulatory functions, as well as testing potential therapies for intervention. The analyses of the cellular events leading up to diabetes may utilize different in vitro cellular assays, immunohistochemistry, and in vivo adoptive transfer, to study mechanisms of the disease and the effects of therapeutic intervention. In this chapter, we describe some common techniques for phenotyping and mechanistic analyses of function, particularly of CD8+ T cells.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Humana Press
ISBN: 9781071603840
ISSN: 1064-3745
Last Modified: 07 Jan 2022 02:07

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