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Mouse models of autoimmune diabetes: the nonobese diabetic (NOD) mouse

Chen, Dawei, Thayer, Terri C., Wen, Li and Wong, F. Susan 2020. Mouse models of autoimmune diabetes: the nonobese diabetic (NOD) mouse. Animal Models of Diabetes, Vol. 2128. Methods in Molecular Biology, New York, NY, USA: Humana Press, pp. 87-92. (10.1007/978-1-0716-0385-7_6)

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There are now a number of different mouse models for type 1 diabetes. The best known is the nonobese diabetic (NOD) mouse which has a genetic susceptibility to autoimmune diabetes with some features that are similar to human type 1 diabetes. The mice also have a propensity to other autoimmune diatheses, including autoimmune thyroid disease and sialadenitis. In addition, it is well known that environmental factors affect the incidence of disease in these mice. While there are other rodent models, including numerous transgenic and knockout models, as well as those that express human proteins, none of these develop spontaneous diabetes over a period of time, when the natural history can be studied. We focus here on the unmanipulated NOD mouse and discuss features of the husbandry and investigation of the mice that allow for use of these long-studied mice in the pathogenesis of an autoimmune type of diabetes.

Item Type: Book Section
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Humana Press
ISBN: 9781071603840
ISSN: 1064-3745
Last Modified: 07 Jan 2022 02:07

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