Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers

Jones, D. Heulyn, Bresciani, Stefano, Tellam, James P., Wojno, Justyna, Cooper, Anthony W. J., Kennedy, Alan R. and Tomkinson, Nicholas C. O. 2016. Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers. Organic and Biomolecular Chemistry 14 (1) , pp. 172-182. 10.1039/C5OB01924A

Full text not available from this repository.

Abstract

The isomers of dibenzylamino-1-methylcyclohexan-1-ol and dibenzylamino-1-trifluoromethylcyclohexan-1-ol have been prepared. The stereochemistry of these compounds was unequivocally assigned through a combination of NMR spectroscopy and single crystal X-ray analysis. The cis-isomer of 3-N,N-dibenzylamino-1-trifluoromethylcyclohexanol and its derivatives display an unusual conformational behaviour in both solution-phase and the solid-state, where the amino group usually adopts an axial conformation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Royal Society of Chemistry
ISSN:	1477-0520
Date of Acceptance:	8 October 2015
Last Modified:	10 Jun 2020 11:30
URI:	https://orca.cardiff.ac.uk/id/eprint/131632

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item