Bashir-Uddin Surfraz, M., Akhtar, Mahmoud and Allemann, Rudolf Konrad ![]() |
Abstract
Pd/C and Pd(OH)2/C catalysts are both poisoned by bis-benzyl protected 6-aminocyclitols thereby inhibiting the hydrogenolysis of benzyl ethers but removing N-Cbz groups chemoselectively. This outcome was unaltered by the use of different hydrogen donors. Replacement of the C-6 nitrogen atom by oxygen resulted in the starting materials being fully deprotected under similar conditions. These findings add cyclitolamines to the list of amines/bases that are poisonous to Pd/C catalysts during hydrogenolysis. Pd/C and Pd(OH)2/C catalysts are both poisoned by bis-benzyl protected 6-aminocyclitols thereby inhibiting the hydrogenolysis of benzyl ethers but removing N-Cbz groups chemoselectively.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry Cardiff Catalysis Institute (CCI) |
Subjects: | Q Science > QD Chemistry |
Uncontrolled Keywords: | Catalysis; Deprotection; Poison |
Publisher: | Elsevier |
ISSN: | 0040-4039 |
Last Modified: | 18 Oct 2022 13:19 |
URI: | https://orca.cardiff.ac.uk/id/eprint/13480 |
Citation Data
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