T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion

Shepherd, Freya R. and McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 2020. T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion. International Journal of Molecular Sciences 21 (17) , 6144. 10.3390/ijms21176144

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Abstract

The human body frequently encounters harmful bacterial pathogens and employs immune defense mechanisms designed to counteract such pathogenic assault. In the adaptive immune system, major histocompatibility complex (MHC)-restricted αβ T cells, along with unconventional αβ or γδ T cells, respond to bacterial antigens to orchestrate persisting protective immune responses and generate immunological memory. Research in the past ten years accelerated our knowledge of how T cells recognize bacterial antigens and how many bacterial species have evolved mechanisms to evade host antimicrobial immune responses. Such escape mechanisms act to corrupt the crosstalk between innate and adaptive immunity, potentially tipping the balance of host immune responses toward pathological rather than protective. This review examines the latest developments in our knowledge of how T cell immunity responds to bacterial pathogens and evaluates some of the mechanisms that pathogenic bacteria use to evade such T cell immunosurveillance, to promote virulence and survival in the host.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	MDPI
ISSN:	1422-0067
Date of First Compliant Deposit:	16 September 2020
Date of Acceptance:	24 August 2020
Last Modified:	06 May 2023 08:20
URI:	https://orca.cardiff.ac.uk/id/eprint/134871

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