Browse by Current Cardiff authors

Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Mata Forsberg, Manuel, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934 and Sverremark-Ekström, Eva 2025. Microbe-responsive human γδ T cells: The peculiar case of Staphylococcus aureus. Immunology & Cell Biology 10.1111/imcb.70060

Davies, Kate ORCID: https://orcid.org/0000-0002-9807-1231, Rizek, Al-Motaz, Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Kollnberger, Simon, Wang, Eddie C. Y. ORCID: https://orcid.org/0000-0002-2243-4964, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Underwood, Jonathan ORCID: https://orcid.org/0000-0001-6963-2821 and Mclaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 2025. NKG2A-mediated immune modulation of natural killer cells by Staphylococcus aureus. The Journal of Immunology , vkaf174. 10.1093/jimmun/vkaf174 Item availability restricted.

Giannoni, Eric, Sanchez, Guillem Sanchez, Verdebout, Isoline, Papadopoulou, Maria, Rezwani, Moosa, Ahmed, Raya, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Fraser, Donald J. ORCID: https://orcid.org/0000-0003-0102-9342, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348, Study, Swiss Pediatric Sepsis, Agyeman, Philipp K.A., Schlapbach, Luregn and Vermijlen, David 2024. Sepsis shapes the human γδ TCR repertoire in an age- and pathogen-dependent manner. European Journal of Immunology 54 (10) , 2451190. 10.1002/eji.202451190

Davies, Kate and McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934 2024. Destabilisation of T cell-dependent humoral immunity in sepsis. Clinical Science 138 (1) , pp. 65-85. 10.1042/CS20230517

Oruganti, Sivakumar, Rodrigues, Patrícia R. S., White, Daniel, Watkins, William ORCID: https://orcid.org/0000-0003-3262-6588, Shapey, Selyf, Barrow, Anna, al Samsam, Rim, Ali, Sara, Gajraj, Malcolm, Skone, Richard, Jardine, Michelle, Evans, Jennifer, Struik, Siske, Song, Jong Eun, Abood, Lloyd, Paquete, Barbara, Foulkes, Sian, Saunders, Benjamin, Strang, Angela, Kotecha, Sarah Joanne, Phillips, Bethan, Evans, Awen, Buchanan, Iona, Bowes, Susan, Ali, Begum, Gore, Maya, Thomas-Turner, Rhian, Andrews, Robert, Zaher, Summia, Sharma, Simran, Chakraborty, Mallinath, Parkinson, Edward ORCID: https://orcid.org/0009-0006-4552-9495, Liberatore, Federico ORCID: https://orcid.org/0000-0001-9900-5108, Woolley, Thomas ORCID: https://orcid.org/0000-0001-6225-5365, Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Davies, Luke C., Moet, Linda, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Watson, Gareth L., O'Donnell, Valerie ORCID: https://orcid.org/0000-0003-4089-8460, Hood, Kerry ORCID: https://orcid.org/0000-0002-5268-8631 and Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 2023. Immune and metabolic markers for identifying and investigating severe Coronavirus disease and Sepsis in children and young people (pSeP/COVID ChYP study): protocol for a prospective cohort study. BMJ Open 13 , e067002. 10.1136/bmjopen-2022-067002

Shepherd, Freya R., Davies, Kate ORCID: https://orcid.org/0000-0002-9807-1231, Miners, Kelly L., Llewellyn-Lacey, Sian, Kollnberger, Simon, Redman, James E. ORCID: https://orcid.org/0000-0001-5492-2869, Grant, Melissa M., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 2023. The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells. Communications Biology 6 , 78. 10.1038/s42003-023-04420-1

Goncharov, Mikhail, Bagaev, Dmitry, Shcherbinin, Dmitrii, Zvyagin, Ivan, Bolotin, Dmitry, Thomas, Paul G., Minervina, Anastasia A., Pogorelyy, Mikhail V., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Nguyen, Thi H. O., Rowntree, Louise C., Clemens, E. Bridie, Kedzierska, Katherine, Dolton, Garry, Rius Rafael, Cristina ORCID: https://orcid.org/0000-0002-1896-1649, Sewell, Andrew ORCID: https://orcid.org/0000-0003-3194-3135, Samir, Jerome, Luciani, Fabio, Zornikova, Ksenia V., Khmelevskaya, Alexandra A., Sheetikov, Saveliy A., Efimov, Grigory A., Chudakov, Dmitry and Shugay, Mikhail 2022. VDJdb in the pandemic era: a compendium of T cell receptors specific for SARS-CoV-2. Nature Methods 19 (9) , 1017–1019. 10.1038/s41592-022-01578-0

Pymm, Phillip, Tenzer, Stefan, Wee, Edmund, Weimershaus, Mirjana, Burgevin, Anne, Kollnberger, Simon, Gerstoft, Jan, Josephs, Tracy M., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Appay, Victor, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Fugger, Lars, Bell, John I., Schild, Hansjörg, van Endert, Peter, Harkiolaki, Maria and Iversen, Astrid K.N. 2022. Epitope length variants balance protective immune responses and viral escape in HIV-1 infection. Cell Reports 38 (9) , 110449. 10.1016/j.celrep.2022.110449

Misheva, Mariya, Kotzamanis, Konstantinos, Davies, Luke C., Tyrrell, Victoria J., Rodrigues, Patricia R. S. ORCID: https://orcid.org/0000-0003-0768-0013, Benavides, Gloria A., Hinz, Christine, Murphy, Robert C., Kennedy, Paul, Taylor, Philip R. ORCID: https://orcid.org/0000-0003-0163-1421, Rosas, Marcela ORCID: https://orcid.org/0000-0002-9442-9638, Jones, Simon A. ORCID: https://orcid.org/0000-0001-7297-9711, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Deshpande, Sumukh, Andrews, Robert, Schebb, Nils Helge, Czubala, Magdalena A. ORCID: https://orcid.org/0000-0001-9881-1095, Gurney, Mark ORCID: https://orcid.org/0000-0003-1119-6638, Aldrovandi, Maceler, Meckelmann, Sven W., Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228, Darley-Usmar, Victor, White, Daniel A. and O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 2022. Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation. Nature Communications 13 (1) , 139. 10.1038/s41467-021-27766-8

Chakraborty, Mallinath, Rodrigues, Patrícia R. S. ORCID: https://orcid.org/0000-0003-0768-0013, Watkins, W. John ORCID: https://orcid.org/0000-0003-3262-6588, Hayward, Angela, Sharma, Alok, Hayward, Rachel, Smit, Elisa, Jones, Rebekka, Goel, Nitin, Asokkumar, Amar, Calvert, Jennifer, Odd, David, Morris, Ian, Doherty, Cora, Elliott, Sian, Strang, Angela, Andrews, Robert, Zaher, Summia, Sharma, Simran, Bell, Sarah, Oruganti, Siva, Smith, Claire, Orme, Judith, Edkins, Sarah ORCID: https://orcid.org/0000-0003-0717-1972, Craigon, Marie, White, Daniel, Dantoft, Widad, Davies, Luke C., Moet, Linda, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Clarkstone, Samantha, Watson, Gareth L., Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631, Kotecha, Sailesh ORCID: https://orcid.org/0000-0003-3535-7627, Morgan, B. Paul ORCID: https://orcid.org/0000-0003-4075-7676, O'Donnell, Valerie B. ORCID: https://orcid.org/0000-0003-4089-8460 and Ghazal, Peter ORCID: https://orcid.org/0000-0003-0035-2228 2021. nSeP: immune and metabolic biomarkers for early detection of neonatal sepsis-protocol for a prospective multicohort study. BMJ Open 11 (12) , e050100. 10.1136/bmjopen-2021-050100

Campion, Suzanne L., Brenna, Elena, Thomson, Elaine, Fischer, Will, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Frahm, Nicole, McElrath, Juliana M., Cohen, Kristen W., Maenza, Janine R., Walsh, Stephen R., Baden, Lindsey R., Haynes, Barton F., Korber, Bette, Borrow, Persephone and McMichael, Andrew J. 2021. Preexisting memory CD4+ T cells contribute to the primary response in an HIV-1 vaccine trial. Journal of Clinical Investigation 131 (23) , e150823. 10.1172/JCI150823

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Knezevic, Lea, Dockree, Tamsin, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Llewellyn-Lacey, Sian, Rubina, Anzelika, Francis, Ore, Cole, David K. ORCID: https://orcid.org/0000-0003-0028-9396, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Bridgeman, John S., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, van den Berg, Hugo A. and Wooldridge, Linda 2021. CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor. Proceedings of the National Academy of Sciences 118 (29) , e2019639118. 10.1073/pnas.2019639118

Narayanan, Gitanjali A., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Meermeier, Erin W., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Swarbrick, Gwendolyn M., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Tran, Jessica G., Worley, Aneta H., Vogt, Todd, Wong, Emily B. and Lewinsohn, David M 2020. The MAIT TCRβ chain contributes to discrimination of microbial ligand. Immunology and Cell Biology 98 (9) , pp. 770-781. 10.1111/imcb.12370

Shepherd, Freya R. and McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 2020. T cell immunity to bacterial pathogens: mechanisms of immune control and bacterial evasion. International Journal of Molecular Sciences 21 (17) , 6144. 10.3390/ijms21176144

Pearson, Frances E., Tullett, Kirsteen M., Leal-Rojas, Ingrid M., Haigh, Oscar L., Masterman, Kelly-Anne, Walpole, Carina, Bridgeman, John S., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly, Llewellyn-Lacey, Sian, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Tunger, Antje, Schmitz, Marc, Miles, John J, Lahoud, Mireille H and Radford, Kristen J 2020. Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1‐specific CD8+ T cells. Clinical and Translational Immunology 9 10.1002/cti2.1141

Edwards, Sarah C., Sutton, Caroline E., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Grant, Emma J., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Roche, Fiona, Dash, Pradyot, Apiwattanakul, Nopporn, Awad, Walid, Miners, Kelly L., Lalor, Stephen J., Ribot, Julie C., Baik, Song, Moran, Barry, McGinley, Aoife, Pivorunas, Valerie, Dowding, Lori, Macoritto, Michael, Paez-Cortez, Jesus, Slavin, Anthony, Anderson, Graham, Silva-Santos, Bruno, Hokamp, Karsten, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Thomas, Paul G., McLoughlin, Rachel M. and Mills, Kingston H.G. 2020. A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans. Journal of Experimental Medicine 217 (5) , e20190834. 10.1084/jem.20190834

Starke, Carly E., Vinton, Carol L., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ortiz, Alexandra M., Mudd, Joseph C., Flynn, Jacob K., Lai, Stephen H., Wu, Fan, Hirsch, Vanessa M., Darko, Samuel, Douek, Daniel C., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Brenchley, Jason M. 2020. SIV-specific CD8+ T cells are clonotypically distinct across lymphoid and mucosal tissues. Journal of Clinical Investigation 130 (2) , pp. 789-798. 10.1172/JCI129161

Brenna, Elena, Davydov, Alexey N., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Bonaiuti, Paolo, Metsger, Maria, Ramsden, James D., Gilbert, Sarah C., Lambe, Teresa, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Campion, Suzanne L., Chudakov, Dmitriy M., Borrow, Persephone and McMichael, Andrew J. 2020. CD4+ T follicular helper cells in human tonsils and blood are clonally convergent but divergent from Non-Tfh CD4+ cells. Cell Reports 30 (1) , pp. 137-152. 10.1016/j.celrep.2019.12.016

Meckiff, Benjamin J., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ryan, Gordon B., Leese, Alison M., James, Eddie A., Price, David A. and Long, Heather M. 2019. Primary EBV infection induces an acute wave of activated antigen-specific cytotoxic CD4+ T cells. Journal of Immunology 203 (3) , ji1900377. 10.4049/jimmunol.1900377

Wong, Emily B., Gold, Marielle C., Meermeier, Erin W., Xulu, Bongiwe Z., Khuzwayo, Sharon, Sullivan, Zuri A., Mahyari, Eisa, Rogers, Zoe, Kløverpris, Hénrik, Sharma, Prabhat K., Worley, Aneta H., Lalloo, Umesh, Baijnath, Prinita, Ambaram, Anish, Naidoo, Leon, Suleman, Moosa, Madansein, Rajhmun, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Miners, Kelly L., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Behar, Samuel M., Nielsen, Morten, Kasprowicz, Victoria O., Leslie, Alasdair, Bishai, William R., Ndung'u, Thumbi and Lewinsohn, David M. 2019. TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis. Communications Biology 2 (1) , -. 10.1038/s42003-019-0442-2

Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F. C. C., Chudakov, Dmitriy M., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Lelieveldt, Boudewijn P. F. and Koning, Frits 2019. Memory CD4+ T cells are generated in the human fetal intestine. Nature Immunology 20 , pp. 301-312. 10.1038/s41590-018-0294-9

Mayassi, Toufic, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Gudjonson, Herman, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Shaw, Dustin G., Tran, Mai T., Rokicka, Jagoda J., Lawrence, Ian, Grenier, Jean-Christophe, van Unen, Vincent, Ciszewski, Cezary, Dimaano, Matthew, Sayegh, Hoda E., Kumar, Vinod, Wijmenga, Cisca, Green, Peter H.R., Gokhale, Ranjana, Jericho, Hilary, Semrad, Carol E., Guandalini, Stefano, Dinner, Aaron R., Kupfer, Sonia S., Reid, Hugh H., Barreiro, Luis B., Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Jabri, Bana 2019. Chronic inflammation permanently reshapes tissue-resident immunity in celiac disease. Cell 176 (5) , 967-981.e19. 10.1016/j.cell.2018.12.039

McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Miners, Kelly L., Llewellyn-Lacey, Sian, Grant, Emma J., Rubina, Anzelika, Gimeno Brias, Silvia, Gostick, Emma, Stacey, Maria A., Orr, Selinda J., Stanton, Richard J. ORCID: https://orcid.org/0000-0002-6799-1182, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337 2019. IL-33 augments virus-specific memory T Cell inflation and potentiates the efficacy of an attenuated cytomegalovirus-based vaccinea. Journal of Immunology 202 (3) , pp. 943-955. 10.4049/jimmunol.1701757

Pogorelyy, Mikhail V., Fedorova, Alla D., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Bagaev, Dmitri V., Eliseev, Alexey V., Mikelov, Artem I., Koneva, Anna E., Zvyagin, Ivan V., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Chudakov, Dmitry M. and Shugay, Mikhail 2018. Exploring the pre-immune landscape of antigen-specific T cells. Genome Medicine 10 , 68. 10.1186/s13073-018-0577-7

Wun, Kwok S., Reijneveld, Josephine F., Cheng, Tan-Yun, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Uldrich, Adam P., Le Nours, Jérôme, Miners, Kelly L., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Grant, Emma J., Haigh, Oscar L., Watkins, Thomas S., Suliman, Sara, Iwany, Sarah, Jimenez, Judith, Calderon, Roger, Tamara, Kattya L., Leon, Segundo R., Murray, Megan B., Mayfield, Jacob A., Altman, John D., Purcell, Anthony W., Miles, John J., Godfrey, Dale I., Gras, Stephanie, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Van Rhijn, Ildiko, Moody, D. Branch and Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522 2018. T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature Immunology 19 , pp. 397-406. 10.1038/s41590-018-0065-7

Culina, Slobodan, Lalanne, Ana Ines, Afonso, Georgia, Cerosaletti, Karen, Pinto, Sheena, Sebastiani, Guido, Kuranda, Klaudia, Nigi, Laura, Eugster, Anne, Østerbye, Thomas, Maugein, Alicia, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Larger, Etienne, Beressi, Jean-Paul, Lissina, Anna, Appay, Victor, Davidson, Howard W., Buus, Søren, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Kuhn, Matthias, Bonifacio, Ezio, Battaglia, Manuela, Caillat-Zucman, Sophie, Dotta, Francesco, Scharfmann, Raphael, Kyewski, Bruno, Mallone, Roberto and ImMaDiab Study Group 2018. Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors. Science Immunology 3 (20) , eaao4013. 10.1126/sciimmunol.aao4013

Shugay, M., Bagaev, D. V., Zvyagin, I. V., Vroomans, R. M., Crawford, J. C., Dolton, Garry M., Komech, Ekaterina A., Sycheva, Anastasiya L., Koneva, Anna E., Egorov, Evgeniy S., Eliseev, Alexey V., Van Dyk, E., Dash, P., Attaf, Meriem, Ruis, Cristina, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Clemens, Ella B., Douek, Daniel C., Luciani, Fabio, Van Baarle, D., Kedzierska, Katherine, Kesmir, Can, Thomas, Paul G., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135 and Chudakov, Dimitry M. 2018. VDJdb: a curated database of T-cell receptor sequences with known antigen specificity. Nucleic Acids Research 46 (D1) , D419-D427. 10.1093/nar/gkx760

Lissina, Anna, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ilander, Mette, Andersson, Emma I., Lewis, Catherine S., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Herman, Andrew, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Llewellyn-Lacey, Sian, Miners, Kelly L., Gostick, Emma, Melenhorst, J. Joseph, Barrett, A. John, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Mustjoki, Satu and Wooldridge, Linda 2018. Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions. Scientific Reports 8 (1) , 2534. 10.1038/s41598-017-18062-x

Culshaw, Abigail, ORCID: https://orcid.org/0000-0002-9856-2938, ORCID: https://orcid.org/0000-0002-7021-5934, , ORCID: https://orcid.org/0000-0002-2020-7522, ORCID: https://orcid.org/0000-0001-9416-2737, ORCID: https://orcid.org/0000-0002-2020-7522 and ORCID: https://orcid.org/0000-0001-9416-2737 2017. Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8+ T cell response. Nature Immunology 18 , pp. 1228-1237. 10.1038/ni.3850

Davey, Martin S., Willcox, Carrie R., Joyce, Stephen P., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Kasatskaya, Sofya A., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Hunter, Stuart, Salim, Mahboob, Mohammed, Fiyaz, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Chudakov, Dmitriy M. and Willcox, Benjamin E. 2017. Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance. Nature Communications 8 , 14760. 10.1038/ncomms14760

Dockree, Tamsin, Holland, Christopher J., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Van Den Berg, Hugo A., Gostick, Emma, Llewellyn-Lacey, Sian, Man, Stephen Tzekwung ORCID: https://orcid.org/0000-0001-9103-1686, Bailey, Mick, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Wooldridge, Linda 2017. CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold. Immunology and Cell Biology 95 (1) , pp. 68-76. 10.1038/icb.2016.85

Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Pearson, James ORCID: https://orcid.org/0000-0002-2867-2269, Gras, Stephanie, Van den berg, Hugo, Lissina, Anya, Llewellyn-Lacey, Sian, Willis, Mark ORCID: https://orcid.org/0000-0003-3024-6063, Dockree, Tamsin, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Ekeruche-Makinde, Julia, Gostick, Emma, Robertson, Neil ORCID: https://orcid.org/0000-0002-5409-4909, Burrows, Scott, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845, Peakman, Mark, Skowera, Ania and Wooldridge, Linda 2016. Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies. Scientific Reports 6 , 35332. 10.1038/srep35332

Pearson, James A. ORCID: https://orcid.org/0000-0002-2867-2269, Thayer, Terri C., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, De Leenheer, Evy, Phillips, Amy, Davies, Joanne, Kakabadse, Dimitri, Miners, Kelly, Morgan, Peter ORCID: https://orcid.org/0000-0002-8555-3493, Wen, Li, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Wong, F. Susan ORCID: https://orcid.org/0000-0002-2812-8845 2016. Proinsulin expression shapes the TCR repertoire but fails to control the development of low-avidity insulin-reactive CD8+ T cells. Diabetes 65 (6) , pp. 1679-1689. 10.2337/db15-1498

Liuzzi, Anna Rita, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Eberl, Matthias ORCID: https://orcid.org/0000-0002-9390-5348 2015. Early innate responses to pathogens: pattern recognition by unconventional human T-cells. Current Opinion in Immunology 36 , pp. 31-37. 10.1016/j.coi.2015.06.002

Neller, Michelle A., Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Matthews, Katherine K., Gostick, Emma, Pentier, Johanne, Dolton, Garry Michael, Schauenburg, Andrea J. A., Koning, Dan, Fontaine Costa, Ana Isabel C. A., Watkins, Thomas S., Venturi, Vanessa, Smith, Corey, Khanna, Rajiv, Miners, Kelly Louise, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Wooldridge, Linda, Cole, David ORCID: https://orcid.org/0000-0003-0028-9396, van Baarle, Debbie, Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Burrows, Scott R., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Miles, John James 2015. Naive CD8+ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamics. Immunology and Cell Biology 93 , pp. 625-633. 10.1038/icb.2015.17

Petersen, J., van Bergen, J., Loh, K. L., Kooy-Winkelaar, Y., Beringer, D. X., Thompson, A., Bakker, S. F., Mulder, C. J. J., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Reid, H. H. and Koning, F. 2015. Determinants of gliadin-specific T cell selection in celiac disease. The Journal of Immunology 194 (12) , pp. 6112-6122. 10.4049/jimmunol.1500161

Kloverpris, H. N., McGregor, R., McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Harndahl, M., Stryhn, A., Carlson, J. M., Koofhethile, C., Gerritsen, B., Ke mir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., Buus, S., Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Goulder, P. J. 2015. CD8+ TCR bias and immunodominance in HIV-1 infection. The Journal of Immunology 194 (11) , pp. 5329-5345. 10.4049/jimmunol.1400854

Roberto, Alessandra, Castagna, Luca, Zanon, Veronica, Bramanti, Stefania, Crocchiolo, Roberto, McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Gandolfi, Sara, Tentorio, Paolo, Sarina, Barbara, Timofeeva, Inna, Santoro, Armando, Carlo-Stella, Carmelo, Bruno, Benedetto, Carniti, Cristiana, Corradini, Paolo, Gostick, Emma, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737, Roederer, Mario, Mavilio, Domenico and Lugli, Enrico 2015. Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation. Blood 125 (18) , pp. 2855-2864. 10.1182/blood-2014-11-608406

Skowera, Ania, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Dolton, Garry Michael, Matthews, Katherine K., Gostick, Emma, Kronenberg-Versteeg, Deborah, Eichmann, Martin, Knight, Robin R., Heck, Susanne, Powrie, Jake, Bingley, Polly J., Dayan, Colin Mark ORCID: https://orcid.org/0000-0002-6557-3462, Miles, John J., Sewell, Andrew K. ORCID: https://orcid.org/0000-0003-3194-3135, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Peakman, Mark 2015. β-Cell-specific CD8 T Cell phenotype in Type 1 diabetes reflects chronic autoantigen exposure. Diabetes 64 (3) , pp. 916-925. 10.2337/db14-0332

Costa, Ana I., Koning, Dan, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Grady, Bart P. X., Schellens, Ingrid M. M., van Ham, Petra, Nijhuis, Monique, Borghans, José A. M., Kesmir, Can, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, van Baarle, Debbie and Silvestri, G. 2015. Complex T-cell receptor repertoire dynamics underlie the CD8+T-cell response to HIV-1. Journal of Virology 89 (1) , pp. 110-119. 10.1128/JVI.01765-14

Pearson, James, Thayer, T. C., McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Miners, Kelly Louise, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Wong, Florence Susan ORCID: https://orcid.org/0000-0002-2812-8845 2014. Analysis of the repertoire of insulin-reactive CD8(+) T cells [Abstract]. Immunology 143 (S2) , p. 152. 10.1111/imm.12406

Bengsch, Bertram, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Martin, Bianca, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Nitschke, Katja, Neumann-Haefelin, Christoph, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Thimme, Robert 2014. Identification of a TSCM phenotype HCV-specific CD8+T cell response with superior functionality in chronic HCV infection [Abstract]. Hepatology 60 , 1071A-1072A.

Kløverpris, Henrik N., McGregor, Reuben, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Stryhn, Anette, Koofhethile, Catherine, Brener, Jacqui, Chen, Fabian, Riddell, Lynn, Graziano, Luzzi, Klenerman, Paul, Leslie, Alasdair, Buus, Søren, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Goulder, Philip 2014. Programmed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load. AIDS 28 (14) , pp. 2007-2021. 10.1097/QAD.0000000000000362

Gold, Marielle C., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Reistetter, Jospeh A., Smyk-Pearson, Sue, Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, Swarbrick, Gwendolyn M., Yu, Yik Y. L., Hansen, Ted H., Lund, Ole, Nielsen, Morten, Gerritsen, Bram, Kesmir, Can, Miles, John J., Lewinsohn, Deborah A., Price, David A. ORCID: https://orcid.org/0000-0001-9416-2737 and Lewinsohn, David M. 2014. MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage. Journal of Experimental Medicine 211 (8) , pp. 1601-1610. 10.1084/jem.20140507

Davies, T. S., Li, N., McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Hughes, Timothy Richard ORCID: https://orcid.org/0000-0003-2348-3490 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2014. Pro- therogenic actions of interferon-gamma on macrophages in atherosclerosis. Cardiology 128 (S1) , p. 278. 10.1159/000365062

Lissina, Anna, Fastenackels, Solène, Inglesias, Maria C., Ladell, Kristin ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James ORCID: https://orcid.org/0000-0002-7021-5934, Briceño, Olivia, Gostick, Emma, Papagno, Laura, Autran, Brigitte, Sauce, Delphine, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Saez-Cirion, Asier and Appay, Victor 2014. The link between CD8+ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate. AIDS 28 (4) , pp. 477-486. 10.1097/QAD.0000000000000175

Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Hashimoto, Masao, Iglesias, Maria Candela, Wilmann, Pascal G., McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Gras, Stéphanie, Chikata, Takayuki, Kuse, Nozomi, Fastenackels, Solène, Gostick, Emma, Bridgeman, John S., Venturi, Vanessa, Arkoub, Zaïna Aït, Agut, Henri, van Bockel, David J., Almeida, Jorge R., Douek, Daniel C., Meyer, Laurence, Venet, Alain, Takiguchi, Masafumi, Rossjohn, Jamie ORCID: https://orcid.org/0000-0002-2020-7522, Price, David ORCID: https://orcid.org/0000-0001-9416-2737 and Appay, Victor 2013. A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38 (3) , pp. 425-436. 10.1016/j.immuni.2012.11.021

Humphreys, Ian R. ORCID: https://orcid.org/0000-0002-9512-5337, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Marsden, Morgan, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Smart, Kathryn, Hindley, James Philip, Bridgeman, Hayley, van den Berg, Hugo A., Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Ager, Ann ORCID: https://orcid.org/0000-0002-5763-8908, Wooldridge, Linda, Godkin, Andrew James ORCID: https://orcid.org/0000-0002-1910-7567 and Gallimore, Awen Myfanwy ORCID: https://orcid.org/0000-0001-6675-7004 2012. Avidity of influenza-specific memory CD8+T-cell populations decays over time compromising antiviral immunity. European Journal of Immunology 42 (12) , pp. 3235-3242. 10.1002/eji.201242575

Doherty, T. Mark, Antrobus, Richard D., Lillie, Patrick J., Berthoud, Tamara K., Spencer, Alexandra J., McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Ladell, Kristin Ingrid ORCID: https://orcid.org/0000-0002-9856-2938, Lambe, Teresa, Milicic, Anita, Price, David ORCID: https://orcid.org/0000-0001-9416-2737, Hill, Adrian V. S. and Gilbert, Sarah C. 2012. A T Cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years. PLoS ONE 7 (10) , e48322. 10.1371/journal.pone.0048322

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Michael, Daryn Robert, Guschina, Irina, Harwood, John L. ORCID: https://orcid.org/0000-0003-2377-2612 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2011. Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages. Lipids 46 (11) , pp. 1053-1061.

Sexton, Keith John, Balharry, Dominique Clare, Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Brewis, Ian Andrew and Berube, Kelly Ann ORCID: https://orcid.org/0000-0002-7471-7229 2011. Proteomic profiling of human respiratory epithelia by iTRAQ reveals biomarkers of exposure and harm by tobacco smoke components. Biomarkers 16 (7) , pp. 567-576. 10.3109/1354750X.2011.608855

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Michael, Daryn Robert, Ashlin, Timothy Gordon and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2011. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Progress in Lipid Research 50 (4) , pp. 331-347. 10.1016/j.plipres.2011.04.002

Li, Na, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Michael, Daryn Robert, Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, Fielding, Ceri Alan ORCID: https://orcid.org/0000-0002-5817-3153 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2010. ERK is integral to the IFN-γ-mediated activation of STAT1, the expression of key genes implicated in atherosclerosis, and the uptake of modified lipoproteins by human macrophages. The Journal of Immunology 185 (5) , pp. 3041-3048. 10.4049/jimmunol.1000993

McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934, Michael, Daryn Robert, Salter, Rebecca Claire, Ashlin, Timothy Gordon, Calder, Claudia Jane, Miller, Ashley M., Liew, Foo Y. and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2010. IL-33 reduces macrophage foam cell formation. The Journal of Immunology 185 (2) , pp. 1222-1229. 10.4049/jimmunol.1000520

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Calder, Claudia Jane, McSharry, Brian P., Sexton, Keith John, Salter, Rebecca Claire, Singh, Nishi N., Wilkinson, Gavin William Grahame ORCID: https://orcid.org/0000-0002-5623-0126, Wang, Edward Chung Yern ORCID: https://orcid.org/0000-0002-2243-4964 and Ramji, Dipak Purshottam ORCID: https://orcid.org/0000-0002-6419-5578 2010. The TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro. Journal of Immunology 184 (10) , pp. 5827-5834. 10.4049/jimmunol.0903782

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Zuo, Jianmin, Grimstead, Julia W., Poghosyan, Zaruhi ORCID: https://orcid.org/0000-0003-4966-7618, Bell, Andrew I., Rowe, Martin and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2009. STAT1 contributes to the maintenance of the latency III viral programme observed in Epstein-Barr virus-transformed B cells and their recognition by CD8+ T cells. Journal of General Virology 90 (9) , pp. 2239-2250. 10.1099/vir.0.011627-0

McLaren, James E. ORCID: https://orcid.org/0000-0002-7021-5934 and Ramji, Dipak P. ORCID: https://orcid.org/0000-0002-6419-5578 2009. Interferon gamma: A master regulator of atherosclerosis. Cytokine & Growth Factor Reviews 20 (2) , pp. 125-135. 10.1016/j.cytogfr.2008.11.003

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Rowe, Martin and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2007. Epstein-Barr virus induces a distinct form of DNA-bound STAT1 compared with that found in interferon-stimulated B lymphocytes. Journal of General Virology 88 (7) , pp. 1876-1886. 10.1099/vir.0.82741-0

McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934 2007. Regulation of the STAT1 by the Epstein-Barr virus. PhD Thesis, Cardiff University.

White, Paul Charles ORCID: https://orcid.org/0000-0002-6562-4696, Shore, A. M., Clement, Mathew ORCID: https://orcid.org/0000-0002-9280-5281, McLaren, James Edward ORCID: https://orcid.org/0000-0002-7021-5934, Soeiro, I., Lam, E. W.-F. and Brennan, Paul ORCID: https://orcid.org/0000-0001-8792-0499 2006. Regulation of cyclin D2 and the cyclin D2 promoter by protein kinase A and CREB in lymphocytes. Oncogene 25 (15) , pp. 2170-2180. 10.1038/sj.onc.1209255