Parkinson's disease laterality: a 11C-PE2I PET imaging study

Roussakis, Andreas-Antonios, Zeng, Zhou, Lao-Kaim, Nicholas P., Martin-Bastida, Antonio, Piccini, Paola and Rosser, Anne ORCID: https://orcid.org/0000-0002-4716-4753 2021. Parkinson's disease laterality: a 11C-PE2I PET imaging study. Journal of Neurology 268 , pp. 582-589. 10.1007/s00415-020-10204-y

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Abstract

Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson’s disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. 11C-PE2I non-displaceable binding potential (BPND) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal 11C-PE2I BPND over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	Anne Rosser contributed to this paper as part of the TRANSEURO consortium.
Publisher:	Springer Verlag
ISSN:	0340-5354
Date of First Compliant Deposit:	22 September 2020
Date of Acceptance:	29 August 2020
Last Modified:	05 May 2023 10:08
URI:	https://orca.cardiff.ac.uk/id/eprint/135016

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