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Update on LIPID MAPS classification, nomenclature and shorthand notation for MS-derived lipid structures

Liebisch, Gerhard, Fahy, Eoin, Aoki, Junken, Dennis, Edward A., Durand, Thierry, Ejsing, Christer, Fedorova, Maria, Feussner, Ivo, Griffiths, William J., Koefeler, Harald, Merrill, Alfred H., Murphy, Robert C., O'Donnell, Valerie B., Oskolkova, Olga V., Subramaniam, Shankar, Wakelam, Michael and Spener, Friedrich 2020. Update on LIPID MAPS classification, nomenclature and shorthand notation for MS-derived lipid structures. Journal of Lipid Research 61 , pp. 1539-1555. 10.1194/jlr.S120001025

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A comprehensive and standardized system to report lipid structures analyzed by mass spectrometry is essential for the communication and storage of lipidomics data. Herein, an update on both the LIPID MAPS classification system and shorthand notation of lipid structures is presented for lipid categories Fatty Acyls (FA), Glycerolipids (GL), Glycerophospholipids (GP), Sphingolipids (SP), and Sterols (ST). With its major changes, i.e. annotation of ring double bond equivalents and number of oxygens, the updated shorthand notation facilitates reporting of newly delineated oxygenated lipid species as well. For standardized reporting in lipidomics, the hierarchical architecture of shorthand notation reflects the diverse structural resolution powers provided by mass spectrometric assays. Moreover, shorthand notation is expanded beyond mammalian phyla to lipids from plant and yeast phyla. Finally, annotation of atoms is included for the use of stable isotope-labelled compounds in metabolic labelling experiments or as internal standards.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Biochemistry and Molecular Biology
ISSN: 0022-2275
Date of First Compliant Deposit: 21 October 2020
Date of Acceptance: 9 October 2020
Last Modified: 13 Jan 2021 14:21

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