Selective vulnerability of inhibitory networks in multiple sclerosis

Zoupi, Lida, Booker, Sam A., Eigel, Dimitri, Werner, Carsten, Kind, Peter C., Spires-Jones, Tara L., Newland, Ben ORCID: https://orcid.org/0000-0002-5214-2604 and Williams, Anna C. 2021. Selective vulnerability of inhibitory networks in multiple sclerosis. Acta Neuropathologica 141 , pp. 415-429. 10.1007/s00401-020-02258-z

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Abstract

In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components and if it is the result of demyelination. Neuropathological examination of secondary progressive MS motor cortices revealed a selective vulnerability of inhibitory interneurons in MS. The generation of a rodent model of focal subpial cortical demyelination reproduces this selective neurodegeneration providing a new preclinical model for the study of neuroprotective treatments.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Springer Verlag
ISSN:	0001-6322
Date of First Compliant Deposit:	21 January 2021
Date of Acceptance:	22 December 2020
Last Modified:	03 May 2023 18:47
URI:	https://orca.cardiff.ac.uk/id/eprint/137854

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