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IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans

Wellington, Dannielle, Yin, Zixi, Abdel-Haq, Adi, Zhang, Liwei, Forbester, Jessica, Kite, Kerry, Rajapaksa, Ushani, Laurenson-Schafer, Henry, Makvandi-Nejad, Shokouh, Jin, Boquan, Bowes, Emma, Manoharan, Krishnageetha, Maldonado-Perez, David, Verrill, Clare, Humphreys, Ian R. and Dong, Tao 2021. IFITM3‐specific antibody reveals IFN preferences and slow IFN induction of the antiviral factor IFITM3 in humans. European Journal of Immunology 51 (3) , pp. 742-745. 10.1002/eji.202048706

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Abstract

Using a specific antibody, we found that expression of the viral restriction factor IFITM3 differs across cell types within the immune compartment with higher expression in myeloid rather than lymphoid cells. IFITM3 expression was increased following IFN stimulation, mostly type I, in immune cells, with the exception of T cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Publisher: Wiley
ISSN: 0014-2980
Date of First Compliant Deposit: 5 February 2021
Date of Acceptance: 22 October 2020
Last Modified: 14 Apr 2021 13:47
URI: http://orca.cardiff.ac.uk/id/eprint/138250

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