An enhanced tilted-angle acoustofluidic chip for cancer cell manipulation

Wu, Fangda, Shen, Ming Hong, Yang, Jian, Wang, Hanlin, Mikhaylov, Roman, Clayton, Aled ORCID: https://orcid.org/0000-0002-3087-9226, Qin, Xinghua, Sun, Chao, Xie, Zhihua ORCID: https://orcid.org/0000-0002-5180-8427, Cai, Meng, Wei, Jun, Liang, Dongfang, Yuan, Fan, Wu, Zhenlin, Fu, Yongqing, Yang, Zhiyong, Sun, Xianfang ORCID: https://orcid.org/0000-0002-6114-0766, Tian, Liangfei and Yang, Xin 2021. An enhanced tilted-angle acoustofluidic chip for cancer cell manipulation. IEEE Electron Device Letters 42 (4) , pp. 577-580. 10.1109/LED.2021.3062292

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Abstract

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and micro-particles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Computer Science & Informatics Advanced Research Computing @ Cardiff (ARCCA)
Publisher:	Institute of Electrical and Electronics Engineers
ISSN:	0741-3106
Date of First Compliant Deposit:	25 February 2021
Date of Acceptance:	23 February 2021
Last Modified:	05 Jan 2024 19:41
URI:	https://orca.cardiff.ac.uk/id/eprint/139000

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