Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

An enhanced tilted-angle acoustofluidic chip for cancer cell manipulation

Wu, Fangda, Shen, Ming Hong, Yang, Jian, Wang, Hanlin, Mikhaylov, Roman, Clayton, Aled, Qin, Xinghua, Sun, Chao, Xie, Zhihua, Cai, Meng, Wei, Jun, Liang, Dongfang, Yuan, Fan, Wu, Zhenlin, Fu, Yongqing, Yang, Zhiyong, Sun, Xianfang, Tian, Liangfei and Yang, Xin 2021. An enhanced tilted-angle acoustofluidic chip for cancer cell manipulation. IEEE Electron Device Letters 42 (4) , pp. 577-580. 10.1109/LED.2021.3062292

[img] PDF - Accepted Post-Print Version
Download (637kB)

Abstract

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and micro-particles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Computer Science & Informatics
Engineering
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
ISSN: 0741-3106
Date of First Compliant Deposit: 25 February 2021
Date of Acceptance: 23 February 2021
Last Modified: 15 Oct 2021 16:52
URI: http://orca.cardiff.ac.uk/id/eprint/139000

Actions (repository staff only)

Edit Item Edit Item